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Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes.
Heart. 2008 Mar; 94(3):290-5.H

Abstract

OBJECTIVE

The purpose of the study was to evaluate the prevalence of CAD as well as plaque morphology in asymptomatic patients with type 2 diabetes using multi-slice computed tomography (MSCT). In addition, the relation between calcium score and MSCT findings was explored.

DESIGN

In 70 patients, coronary calcium scoring and non-invasive coronary angiography were performed. Angiograms showing atherosclerosis were further classified as obstructive (> or =50% luminal narrowing) CAD or not. Plaque type (non-calcified, mixed and calcified) was determined. Finally, the relation between calcium score and MSCT findings was explored.

RESULTS

A calcium score <10 was observed in 31 (44%) patients. A calcium score of 10-100 was observed in 14 (20%) patients while a score of 101-400 or >400 was identified in 12 (17%) and 13 (19%) patients respectively. Non-invasive coronary angiography showed CAD in 56 (80%) patients. 322 coronary segments with plaque were identified, of which 132 (41%) contained non-calcified plaques, 65 (20%) mixed plaques and 125 (39%) calcified plaques. The percentage of patients with obstructive CAD paralleled increasing calcium score. The presence of CAD was noted in 17 (55%) patients with no or minimal calcium (score <10).

CONCLUSIONS

MSCT angiography detected a high prevalence of CAD in asymptomatic patients with type 2 diabetes. A relatively high proportion of plaques were non-calcified (41%). Importantly, a calcium score <10 did not exclude CAD in these patients. MSCT might be a useful technique to identify CAD in asymptomatic patients with type 2 diabetes with incremental value over calcium scoring.

Authors+Show Affiliations

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. a.j.h.a.scholte@lumc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17646190

Citation

Scholte, A J H A., et al. "Prevalence of Coronary Artery Disease and Plaque Morphology Assessed By Multi-slice Computed Tomography Coronary Angiography and Calcium Scoring in Asymptomatic Patients With Type 2 Diabetes." Heart (British Cardiac Society), vol. 94, no. 3, 2008, pp. 290-5.
Scholte AJ, Schuijf JD, Kharagjitsingh AV, et al. Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes. Heart. 2008;94(3):290-5.
Scholte, A. J., Schuijf, J. D., Kharagjitsingh, A. V., Jukema, J. W., Pundziute, G., van der Wall, E. E., & Bax, J. J. (2008). Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes. Heart (British Cardiac Society), 94(3), 290-5.
Scholte AJ, et al. Prevalence of Coronary Artery Disease and Plaque Morphology Assessed By Multi-slice Computed Tomography Coronary Angiography and Calcium Scoring in Asymptomatic Patients With Type 2 Diabetes. Heart. 2008;94(3):290-5. PubMed PMID: 17646190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes. AU - Scholte,A J H A, AU - Schuijf,J D, AU - Kharagjitsingh,A V, AU - Jukema,J W, AU - Pundziute,G, AU - van der Wall,E E, AU - Bax,J J, Y1 - 2007/07/23/ PY - 2007/7/25/pubmed PY - 2008/4/29/medline PY - 2007/7/25/entrez SP - 290 EP - 5 JF - Heart (British Cardiac Society) JO - Heart VL - 94 IS - 3 N2 - OBJECTIVE: The purpose of the study was to evaluate the prevalence of CAD as well as plaque morphology in asymptomatic patients with type 2 diabetes using multi-slice computed tomography (MSCT). In addition, the relation between calcium score and MSCT findings was explored. DESIGN: In 70 patients, coronary calcium scoring and non-invasive coronary angiography were performed. Angiograms showing atherosclerosis were further classified as obstructive (> or =50% luminal narrowing) CAD or not. Plaque type (non-calcified, mixed and calcified) was determined. Finally, the relation between calcium score and MSCT findings was explored. RESULTS: A calcium score <10 was observed in 31 (44%) patients. A calcium score of 10-100 was observed in 14 (20%) patients while a score of 101-400 or >400 was identified in 12 (17%) and 13 (19%) patients respectively. Non-invasive coronary angiography showed CAD in 56 (80%) patients. 322 coronary segments with plaque were identified, of which 132 (41%) contained non-calcified plaques, 65 (20%) mixed plaques and 125 (39%) calcified plaques. The percentage of patients with obstructive CAD paralleled increasing calcium score. The presence of CAD was noted in 17 (55%) patients with no or minimal calcium (score <10). CONCLUSIONS: MSCT angiography detected a high prevalence of CAD in asymptomatic patients with type 2 diabetes. A relatively high proportion of plaques were non-calcified (41%). Importantly, a calcium score <10 did not exclude CAD in these patients. MSCT might be a useful technique to identify CAD in asymptomatic patients with type 2 diabetes with incremental value over calcium scoring. SN - 1468-201X UR - https://www.unboundmedicine.com/medline/citation/17646190/Prevalence_of_coronary_artery_disease_and_plaque_morphology_assessed_by_multi_slice_computed_tomography_coronary_angiography_and_calcium_scoring_in_asymptomatic_patients_with_type_2_diabetes_ DB - PRIME DP - Unbound Medicine ER -