Tags

Type your tag names separated by a space and hit enter

In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution.
Neurology. 2007 Jul 24; 69(4):356-9.Neur

Abstract

We used an autopsy series to determine whether the newest dementia with Lewy bodies (DLB) consensus pathologic classification correlates with premortem diagnosis of DLB. Neocortical sections from a total of 95 cases with Lewy bodies were stained with alpha-synuclein antibodies. We assigned cases according to the DLB consensus' categories and found a significant association with the premortem clinical diagnosis of DLB. Clinical diagnosis of DLB, however, depended on the presence of low Alzheimer disease pathology (by Braak staging) rather than on Lewy body distribution.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Weisman D
Department of Neurosciences, University of California, San Diego, CA, USA. davew@graffiti.net
Cho M
No affiliation info available
Taylor C
No affiliation info available
Adame A
No affiliation info available
Thal LJ
No affiliation info available
Hansen LA
No affiliation info available

MeSH

Alzheimer DiseaseBrainBrain StemDiagnosis, DifferentialHumansImmunohistochemistryLewy BodiesLewy Body DiseaseLimbic SystemNeocortexNeuronsPhenotypePredictive Value of Testsalpha-Synuclein

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17646627

Citation

Weisman, D, et al. "In Dementia With Lewy Bodies, Braak Stage Determines Phenotype, Not Lewy Body Distribution." Neurology, vol. 69, no. 4, 2007, pp. 356-9.
Weisman D, Cho M, Taylor C, et al. In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution. Neurology. 2007;69(4):356-9.
Weisman, D., Cho, M., Taylor, C., Adame, A., Thal, L. J., & Hansen, L. A. (2007). In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution. Neurology, 69(4), 356-9.
Weisman D, et al. In Dementia With Lewy Bodies, Braak Stage Determines Phenotype, Not Lewy Body Distribution. Neurology. 2007 Jul 24;69(4):356-9. PubMed PMID: 17646627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution. AU - Weisman,D, AU - Cho,M, AU - Taylor,C, AU - Adame,A, AU - Thal,L J, AU - Hansen,L A, PY - 2007/7/25/pubmed PY - 2007/8/21/medline PY - 2007/7/25/entrez SP - 356 EP - 9 JF - Neurology JO - Neurology VL - 69 IS - 4 N2 - We used an autopsy series to determine whether the newest dementia with Lewy bodies (DLB) consensus pathologic classification correlates with premortem diagnosis of DLB. Neocortical sections from a total of 95 cases with Lewy bodies were stained with alpha-synuclein antibodies. We assigned cases according to the DLB consensus' categories and found a significant association with the premortem clinical diagnosis of DLB. Clinical diagnosis of DLB, however, depended on the presence of low Alzheimer disease pathology (by Braak staging) rather than on Lewy body distribution. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17646627/In_dementia_with_Lewy_bodies_Braak_stage_determines_phenotype_not_Lewy_body_distribution_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=17646627 DB - PRIME DP - Unbound Medicine ER -