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Relationship between the cardiac response to acute intoxication and alcohol-induced subjective effects throughout the blood alcohol concentration curve.
Hum Psychopharmacol. 2007 Oct; 22(7):437-43.HP

Abstract

RATIONALE

There is evidence to suggest that individual differences in the subjective response to alcohol exist and exaggerated cardiac response to alcohol has been suggested to be a marker of increased sensitivity to the stimulant properties of alcohol.

OBJECTIVES

The present investigation examines the relationship between cardiac reactivity to alcohol measured on the ascending limb of the Blood Alcohol Concentration (BAC) curve and the subjective stimulant and sedative effects of alcohol throughout the BAC curve.

METHODS

The stimulant and sedative effects of alcohol anticipatory to alcohol and during the ascending and descending limbs of the BAC curve were evaluated using the Biphasic Alcohol Effects Scale in 39 male social drinkers.

RESULTS

Cardiac response to ethanol measured on the ascending limb of the BAC curve was positively correlated with intoxicated stimulant effects at numerous time points during the ascending and descending limbs of the BAC curve (ps < 0.01). No associations were found between cardiac change following alcohol and alcohol-related sedative effects at any time point.

CONCLUSIONS

Objective and subjective reports of stimulation post-alcohol ingestion may increase risk for problematic drinking.

Authors+Show Affiliations

Department of Psychology, University of New Brunswick-Saint John campus, New Brunswick, Canada. cbrunell@unbsj.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17647297

Citation

Brunelle, Caroline, et al. "Relationship Between the Cardiac Response to Acute Intoxication and Alcohol-induced Subjective Effects Throughout the Blood Alcohol Concentration Curve." Human Psychopharmacology, vol. 22, no. 7, 2007, pp. 437-43.
Brunelle C, Barrett SP, Pihl RO. Relationship between the cardiac response to acute intoxication and alcohol-induced subjective effects throughout the blood alcohol concentration curve. Hum Psychopharmacol. 2007;22(7):437-43.
Brunelle, C., Barrett, S. P., & Pihl, R. O. (2007). Relationship between the cardiac response to acute intoxication and alcohol-induced subjective effects throughout the blood alcohol concentration curve. Human Psychopharmacology, 22(7), 437-43.
Brunelle C, Barrett SP, Pihl RO. Relationship Between the Cardiac Response to Acute Intoxication and Alcohol-induced Subjective Effects Throughout the Blood Alcohol Concentration Curve. Hum Psychopharmacol. 2007;22(7):437-43. PubMed PMID: 17647297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between the cardiac response to acute intoxication and alcohol-induced subjective effects throughout the blood alcohol concentration curve. AU - Brunelle,Caroline, AU - Barrett,Sean P, AU - Pihl,Robert O, PY - 2007/7/25/pubmed PY - 2008/1/18/medline PY - 2007/7/25/entrez SP - 437 EP - 43 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 22 IS - 7 N2 - RATIONALE: There is evidence to suggest that individual differences in the subjective response to alcohol exist and exaggerated cardiac response to alcohol has been suggested to be a marker of increased sensitivity to the stimulant properties of alcohol. OBJECTIVES: The present investigation examines the relationship between cardiac reactivity to alcohol measured on the ascending limb of the Blood Alcohol Concentration (BAC) curve and the subjective stimulant and sedative effects of alcohol throughout the BAC curve. METHODS: The stimulant and sedative effects of alcohol anticipatory to alcohol and during the ascending and descending limbs of the BAC curve were evaluated using the Biphasic Alcohol Effects Scale in 39 male social drinkers. RESULTS: Cardiac response to ethanol measured on the ascending limb of the BAC curve was positively correlated with intoxicated stimulant effects at numerous time points during the ascending and descending limbs of the BAC curve (ps < 0.01). No associations were found between cardiac change following alcohol and alcohol-related sedative effects at any time point. CONCLUSIONS: Objective and subjective reports of stimulation post-alcohol ingestion may increase risk for problematic drinking. SN - 0885-6222 UR - https://www.unboundmedicine.com/medline/citation/17647297/Relationship_between_the_cardiac_response_to_acute_intoxication_and_alcohol_induced_subjective_effects_throughout_the_blood_alcohol_concentration_curve_ L2 - https://doi.org/10.1002/hup.866 DB - PRIME DP - Unbound Medicine ER -