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Antihyperglycemic property of Tragia cannabina in streptozotocin-induced diabetic rats.
J Med Food. 2007 Jun; 10(2):361-5.JM

Abstract

The present study was performed to investigate the efficacy of an ethanol extract of the roots of Tragia cannabina for antihyperglycemic and antioxidant effects in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were administered T. cannabina (250 mg/kg) orally for 21 days, and blood glucose level was measured weekly. At the end of 21 days, concentrations of serum lipids such as total cholesterol, triglycerides, and high-density lipoprotein (HDL) and protein markers such as total protein, albumin, globulin, and albumin:globulin ratio (A:G) were estimated. Also, levels of enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and alkaline phosphatase (ALP) were determined. Antioxidant activity of the extract was evaluated by estimating lipid peroxides (LPO), superoxide dismutase (SOD), and catalase in liver of normal control and STZ- and extract-treated rats. Histopathological changes of liver and kidney were also studied in STZ-induced diabetic animals and normal controls. All these effects produced by the extract were compared with glibenclamide, a standard antidiabetic drug. Oral administration of T. cannabina for 21 days resulted in a significant reduction in blood glucose level, lipid concentration, and SGOT, SGPT, ALP, and LPO levels accompanied by an increase in the levels of SOD and catalase in liver tissues of STZ-induced diabetic rats. Altered levels of protein markers also reverted back to normal. Histopathological changes of liver and kidney were returned to normal. The effects produced by the extract were comparable to that of glibenclamide. In conclusion, the T. cannabina showed significant antihyperglycemic and antioxidant effects in STZ-induced diabetic rats.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation (Deemed University), Salem, India. writetojothi@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17651075

Citation

Sivajothi, Vaiyapuri, et al. "Antihyperglycemic Property of Tragia Cannabina in Streptozotocin-induced Diabetic Rats." Journal of Medicinal Food, vol. 10, no. 2, 2007, pp. 361-5.
Sivajothi V, Dey A, Jayakar B, et al. Antihyperglycemic property of Tragia cannabina in streptozotocin-induced diabetic rats. J Med Food. 2007;10(2):361-5.
Sivajothi, V., Dey, A., Jayakar, B., & Rajkapoor, B. (2007). Antihyperglycemic property of Tragia cannabina in streptozotocin-induced diabetic rats. Journal of Medicinal Food, 10(2), 361-5.
Sivajothi V, et al. Antihyperglycemic Property of Tragia Cannabina in Streptozotocin-induced Diabetic Rats. J Med Food. 2007;10(2):361-5. PubMed PMID: 17651075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycemic property of Tragia cannabina in streptozotocin-induced diabetic rats. AU - Sivajothi,Vaiyapuri, AU - Dey,Akalanka, AU - Jayakar,Balasundaram, AU - Rajkapoor,Balasubramanian, PY - 2007/7/27/pubmed PY - 2007/12/6/medline PY - 2007/7/27/entrez SP - 361 EP - 5 JF - Journal of medicinal food JO - J Med Food VL - 10 IS - 2 N2 - The present study was performed to investigate the efficacy of an ethanol extract of the roots of Tragia cannabina for antihyperglycemic and antioxidant effects in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were administered T. cannabina (250 mg/kg) orally for 21 days, and blood glucose level was measured weekly. At the end of 21 days, concentrations of serum lipids such as total cholesterol, triglycerides, and high-density lipoprotein (HDL) and protein markers such as total protein, albumin, globulin, and albumin:globulin ratio (A:G) were estimated. Also, levels of enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and alkaline phosphatase (ALP) were determined. Antioxidant activity of the extract was evaluated by estimating lipid peroxides (LPO), superoxide dismutase (SOD), and catalase in liver of normal control and STZ- and extract-treated rats. Histopathological changes of liver and kidney were also studied in STZ-induced diabetic animals and normal controls. All these effects produced by the extract were compared with glibenclamide, a standard antidiabetic drug. Oral administration of T. cannabina for 21 days resulted in a significant reduction in blood glucose level, lipid concentration, and SGOT, SGPT, ALP, and LPO levels accompanied by an increase in the levels of SOD and catalase in liver tissues of STZ-induced diabetic rats. Altered levels of protein markers also reverted back to normal. Histopathological changes of liver and kidney were returned to normal. The effects produced by the extract were comparable to that of glibenclamide. In conclusion, the T. cannabina showed significant antihyperglycemic and antioxidant effects in STZ-induced diabetic rats. SN - 1096-620X UR - https://www.unboundmedicine.com/medline/citation/17651075/Antihyperglycemic_property_of_Tragia_cannabina_in_streptozotocin_induced_diabetic_rats_ L2 - https://www.liebertpub.com/doi/full/10.1089/jmf.2006.030?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -