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Differences in parapapillary atrophy between glaucomatous and normal eyes: the Beijing Eye Study.
Am J Ophthalmol 2007; 144(4):541-6AJ

Abstract

PURPOSE

To determine in a population-based study whether parapapillary atrophy is associated with glaucoma.

DESIGN

Population-based cross-sectional study.

METHODS

The Beijing Eye Study included 4,439 of 5,324 subjects invited to participate (response rate, 83.4%). Mean age was 56.2 +/- 10.6 years (range, 40 to 101 years). Color optic disk photographs (30 degrees) were examined morphometrically. Parapapillary atrophy was divided into alpha and beta zones. Glaucomatous optic nerve atrophy was defined by a glaucomatous optic nerve head appearance.

RESULTS

After excluding highly myopic eyes, data from 4,003 (90.2%) subjects entered the statistical analysis. Glaucomatous optic nerve damage was detected in 93 (2.3%) subjects. The beta zone of parapapillary atrophy as a whole and measured separately in four disk sectors was significantly larger and occurred significantly more frequently in the glaucomatous group than in the nonglaucomatous group (beta zone total area, 1.21 +/- 1.92 mm2 vs 0.32 +/- 0.99 mm2; P < .001). In multiple regression analysis, area of beta zone was significantly associated with age (P < .001), myopic refractive error (P < .001), and presence of glaucomatous optic nerve damage (P < .001), with no significant difference between chronic open-angle glaucoma (n = 72) and chronic angle-closure glaucoma (n = 21; beta zone area, 1.20 +/- 0.39 mm2 vs 1.19 +/- 0.46 mm2; P = .69).

CONCLUSIONS

In a population-based setting, the beta zone of parapapillary atrophy is significantly larger and occurs more frequently in glaucomatous eyes than in normal eyes of Chinese adults, with no marked difference between chronic open-angle glaucoma and primary angle-closure glaucoma.

Authors+Show Affiliations

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17651676

Citation

Xu, Liang, et al. "Differences in Parapapillary Atrophy Between Glaucomatous and Normal Eyes: the Beijing Eye Study." American Journal of Ophthalmology, vol. 144, no. 4, 2007, pp. 541-6.
Xu L, Wang Y, Yang H, et al. Differences in parapapillary atrophy between glaucomatous and normal eyes: the Beijing Eye Study. Am J Ophthalmol. 2007;144(4):541-6.
Xu, L., Wang, Y., Yang, H., & Jonas, J. B. (2007). Differences in parapapillary atrophy between glaucomatous and normal eyes: the Beijing Eye Study. American Journal of Ophthalmology, 144(4), pp. 541-6.
Xu L, et al. Differences in Parapapillary Atrophy Between Glaucomatous and Normal Eyes: the Beijing Eye Study. Am J Ophthalmol. 2007;144(4):541-6. PubMed PMID: 17651676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in parapapillary atrophy between glaucomatous and normal eyes: the Beijing Eye Study. AU - Xu,Liang, AU - Wang,Yaxing, AU - Yang,Hua, AU - Jonas,Jost B, Y1 - 2007/07/25/ PY - 2007/02/13/received PY - 2007/05/21/revised PY - 2007/05/24/accepted PY - 2007/7/27/pubmed PY - 2007/10/30/medline PY - 2007/7/27/entrez SP - 541 EP - 6 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 144 IS - 4 N2 - PURPOSE: To determine in a population-based study whether parapapillary atrophy is associated with glaucoma. DESIGN: Population-based cross-sectional study. METHODS: The Beijing Eye Study included 4,439 of 5,324 subjects invited to participate (response rate, 83.4%). Mean age was 56.2 +/- 10.6 years (range, 40 to 101 years). Color optic disk photographs (30 degrees) were examined morphometrically. Parapapillary atrophy was divided into alpha and beta zones. Glaucomatous optic nerve atrophy was defined by a glaucomatous optic nerve head appearance. RESULTS: After excluding highly myopic eyes, data from 4,003 (90.2%) subjects entered the statistical analysis. Glaucomatous optic nerve damage was detected in 93 (2.3%) subjects. The beta zone of parapapillary atrophy as a whole and measured separately in four disk sectors was significantly larger and occurred significantly more frequently in the glaucomatous group than in the nonglaucomatous group (beta zone total area, 1.21 +/- 1.92 mm2 vs 0.32 +/- 0.99 mm2; P < .001). In multiple regression analysis, area of beta zone was significantly associated with age (P < .001), myopic refractive error (P < .001), and presence of glaucomatous optic nerve damage (P < .001), with no significant difference between chronic open-angle glaucoma (n = 72) and chronic angle-closure glaucoma (n = 21; beta zone area, 1.20 +/- 0.39 mm2 vs 1.19 +/- 0.46 mm2; P = .69). CONCLUSIONS: In a population-based setting, the beta zone of parapapillary atrophy is significantly larger and occurs more frequently in glaucomatous eyes than in normal eyes of Chinese adults, with no marked difference between chronic open-angle glaucoma and primary angle-closure glaucoma. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/17651676/Differences_in_parapapillary_atrophy_between_glaucomatous_and_normal_eyes:_the_Beijing_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(07)00521-1 DB - PRIME DP - Unbound Medicine ER -