Tags

Type your tag names separated by a space and hit enter

The surgical learning curve for prostate cancer control after radical prostatectomy.
J Natl Cancer Inst. 2007 Aug 01; 99(15):1171-7.JNCI

Abstract

BACKGROUND

The learning curve for surgery--i.e., improvement in surgical outcomes with increasing surgeon experience--remains primarily a theoretical concept; actual curves based on surgical outcome data are rarely presented. We analyzed the surgical learning curve for prostate cancer recurrence after radical prostatectomy.

METHODS

The study cohort included 7765 prostate cancer patients who were treated with radical prostatectomy by one of 72 surgeons at four major US academic medical centers between 1987 and 2003. For each patient, surgeon experience was coded as the total number of radical prostatectomies performed by the surgeon before the patient's operation. Multivariable survival-time regression models were used to evaluate the association between surgeon experience and prostate cancer recurrence, defined as a serum prostate-specific antigen (PSA) of more than 0.4 ng/mL followed by a subsequent higher PSA level (i.e., biochemical recurrence), with adjustment for established clinical and tumor characteristics. All P values are two-sided.

RESULTS

The learning curve for prostate cancer recurrence after radical prostatectomy was steep and did not start to plateau until a surgeon had completed approximately 250 prior operations. The predicted probabilities of recurrence at 5 years were 17.9% (95% confidence interval [CI] = 12.1% to 25.6%) for patients treated by surgeons with 10 prior operations and 10.7% (95% CI = 7.1% to 15.9%) for patients treated by surgeons with 250 prior operations (difference = 7.2%, 95% CI = 4.6% to 10.1%; P<.001). This finding was robust to sensitivity analysis; in particular, the results were unaffected if we restricted the sample to patients treated after 1995, when stage migration related to the advent of PSA screening appeared largely complete.

CONCLUSIONS

As a surgeon's experience increases, cancer control after radical prostatectomy improves, presumably because of improved surgical technique. Further research is needed to examine the specific techniques used by experienced surgeons that are associated with improved outcomes.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA. vickersa@mskcc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17652279

Citation

Vickers, Andrew J., et al. "The Surgical Learning Curve for Prostate Cancer Control After Radical Prostatectomy." Journal of the National Cancer Institute, vol. 99, no. 15, 2007, pp. 1171-7.
Vickers AJ, Bianco FJ, Serio AM, et al. The surgical learning curve for prostate cancer control after radical prostatectomy. J Natl Cancer Inst. 2007;99(15):1171-7.
Vickers, A. J., Bianco, F. J., Serio, A. M., Eastham, J. A., Schrag, D., Klein, E. A., Reuther, A. M., Kattan, M. W., Pontes, J. E., & Scardino, P. T. (2007). The surgical learning curve for prostate cancer control after radical prostatectomy. Journal of the National Cancer Institute, 99(15), 1171-7.
Vickers AJ, et al. The Surgical Learning Curve for Prostate Cancer Control After Radical Prostatectomy. J Natl Cancer Inst. 2007 Aug 1;99(15):1171-7. PubMed PMID: 17652279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The surgical learning curve for prostate cancer control after radical prostatectomy. AU - Vickers,Andrew J, AU - Bianco,Fernando J, AU - Serio,Angel M, AU - Eastham,James A, AU - Schrag,Deborah, AU - Klein,Eric A, AU - Reuther,Alwyn M, AU - Kattan,Michael W, AU - Pontes,J Edson, AU - Scardino,Peter T, Y1 - 2007/07/24/ PY - 2007/7/27/pubmed PY - 2007/8/19/medline PY - 2007/7/27/entrez SP - 1171 EP - 7 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 99 IS - 15 N2 - BACKGROUND: The learning curve for surgery--i.e., improvement in surgical outcomes with increasing surgeon experience--remains primarily a theoretical concept; actual curves based on surgical outcome data are rarely presented. We analyzed the surgical learning curve for prostate cancer recurrence after radical prostatectomy. METHODS: The study cohort included 7765 prostate cancer patients who were treated with radical prostatectomy by one of 72 surgeons at four major US academic medical centers between 1987 and 2003. For each patient, surgeon experience was coded as the total number of radical prostatectomies performed by the surgeon before the patient's operation. Multivariable survival-time regression models were used to evaluate the association between surgeon experience and prostate cancer recurrence, defined as a serum prostate-specific antigen (PSA) of more than 0.4 ng/mL followed by a subsequent higher PSA level (i.e., biochemical recurrence), with adjustment for established clinical and tumor characteristics. All P values are two-sided. RESULTS: The learning curve for prostate cancer recurrence after radical prostatectomy was steep and did not start to plateau until a surgeon had completed approximately 250 prior operations. The predicted probabilities of recurrence at 5 years were 17.9% (95% confidence interval [CI] = 12.1% to 25.6%) for patients treated by surgeons with 10 prior operations and 10.7% (95% CI = 7.1% to 15.9%) for patients treated by surgeons with 250 prior operations (difference = 7.2%, 95% CI = 4.6% to 10.1%; P<.001). This finding was robust to sensitivity analysis; in particular, the results were unaffected if we restricted the sample to patients treated after 1995, when stage migration related to the advent of PSA screening appeared largely complete. CONCLUSIONS: As a surgeon's experience increases, cancer control after radical prostatectomy improves, presumably because of improved surgical technique. Further research is needed to examine the specific techniques used by experienced surgeons that are associated with improved outcomes. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/17652279/The_surgical_learning_curve_for_prostate_cancer_control_after_radical_prostatectomy_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djm060 DB - PRIME DP - Unbound Medicine ER -