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Combined but not individual administration of beta-adrenergic and serotonergic antagonists impairs water maze acquisition in the rat.
Neuropsychopharmacology. 2008 May; 33(6):1298-311.N

Abstract

This study examined the effects of serotonergic depletion and beta-adrenergic antagonism on performance in both visible platform and hidden platform versions of the water maze task. Male Long-Evans rats received systemic injections of p-chlorophenylalanine (500 mg/kg x 2) to deplete serotonin, or propranolol (20 or 40 mg/kg) to antagonize beta-adrenergic receptors. Some rats received treatments in combination. To separate strategies learning from spatial learning, half of the rats underwent Morris' water maze strategies pretraining before drug administration and spatial training. Individual depletion of serotonin or antagonism of beta-adrenergic receptors caused few or no impairments in either naive or pretrained rats in either version of the task. In contrast, combined depletion of serotonin and antagonism of beta-adrenergic receptors impaired naive rats in the visible platform task and impaired both naive and strategies-pretrained rats in the hidden platform task, and also caused sensorimotor impairments. This is the first finding of a 'global' water maze task/sensorimotor impairment with combined administration of two agents that, at the high doses that were given individually, produced few or no impairments. The data imply that (1) serotonergic and beta-adrenergic systems may interact in a manner that is important for adaptive behavior; (2) impairments in these systems found in Alzheimer patients may be important for their cognitive and behavioral impairments; and (3) the approach used here can model aspects of the cognitive and behavioral impairments in Alzheimer disease.

Authors+Show Affiliations

Department of Psychology, University of Western Ontario, London, ON, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17653108

Citation

Kenton, Laura, et al. "Combined but Not Individual Administration of Beta-adrenergic and Serotonergic Antagonists Impairs Water Maze Acquisition in the Rat." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 33, no. 6, 2008, pp. 1298-311.
Kenton L, Boon F, Cain DP. Combined but not individual administration of beta-adrenergic and serotonergic antagonists impairs water maze acquisition in the rat. Neuropsychopharmacology. 2008;33(6):1298-311.
Kenton, L., Boon, F., & Cain, D. P. (2008). Combined but not individual administration of beta-adrenergic and serotonergic antagonists impairs water maze acquisition in the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 33(6), 1298-311.
Kenton L, Boon F, Cain DP. Combined but Not Individual Administration of Beta-adrenergic and Serotonergic Antagonists Impairs Water Maze Acquisition in the Rat. Neuropsychopharmacology. 2008;33(6):1298-311. PubMed PMID: 17653108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined but not individual administration of beta-adrenergic and serotonergic antagonists impairs water maze acquisition in the rat. AU - Kenton,Laura, AU - Boon,Francis, AU - Cain,Donald P, Y1 - 2007/07/25/ PY - 2007/7/27/pubmed PY - 2008/8/8/medline PY - 2007/7/27/entrez SP - 1298 EP - 311 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 33 IS - 6 N2 - This study examined the effects of serotonergic depletion and beta-adrenergic antagonism on performance in both visible platform and hidden platform versions of the water maze task. Male Long-Evans rats received systemic injections of p-chlorophenylalanine (500 mg/kg x 2) to deplete serotonin, or propranolol (20 or 40 mg/kg) to antagonize beta-adrenergic receptors. Some rats received treatments in combination. To separate strategies learning from spatial learning, half of the rats underwent Morris' water maze strategies pretraining before drug administration and spatial training. Individual depletion of serotonin or antagonism of beta-adrenergic receptors caused few or no impairments in either naive or pretrained rats in either version of the task. In contrast, combined depletion of serotonin and antagonism of beta-adrenergic receptors impaired naive rats in the visible platform task and impaired both naive and strategies-pretrained rats in the hidden platform task, and also caused sensorimotor impairments. This is the first finding of a 'global' water maze task/sensorimotor impairment with combined administration of two agents that, at the high doses that were given individually, produced few or no impairments. The data imply that (1) serotonergic and beta-adrenergic systems may interact in a manner that is important for adaptive behavior; (2) impairments in these systems found in Alzheimer patients may be important for their cognitive and behavioral impairments; and (3) the approach used here can model aspects of the cognitive and behavioral impairments in Alzheimer disease. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/17653108/Combined_but_not_individual_administration_of_beta_adrenergic_and_serotonergic_antagonists_impairs_water_maze_acquisition_in_the_rat_ L2 - https://medlineplus.gov/memory.html DB - PRIME DP - Unbound Medicine ER -