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Chiral amines as organocatalysts for asymmetric conjugate addition to nitroolefins and vinyl sulfones via enamine activation.
Chem Commun (Camb). 2007 Aug 14CC

Abstract

Over the last decade the potential of organocatalysis has successfully been demonstrated. In particular, chiral amines such as pyrrolidine analogues have emerged as a broadly applicable class of organocatalyst for asymmetric conjugate addition via enamine activation. This Feature Article documents the development of these catalysts, emphasizing the design and mechanistic features that supply high selectivity in asymmetric Michael reactions.

Authors+Show Affiliations

Sulzer-Mossé S
Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, CH-1211 Geneva, Switzerland.
Alexakis A
No affiliation info available

MeSH

AlkenesAminesCatalysisNitro CompoundsPyrrolidinesStereoisomerismSulfonesVinyl Compounds

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17653365

Citation

Sulzer-Mossé, Sarah, and Alexandre Alexakis. "Chiral Amines as Organocatalysts for Asymmetric Conjugate Addition to Nitroolefins and Vinyl Sulfones Via Enamine Activation." Chemical Communications (Cambridge, England), 2007, pp. 3123-35.
Sulzer-Mossé S, Alexakis A. Chiral amines as organocatalysts for asymmetric conjugate addition to nitroolefins and vinyl sulfones via enamine activation. Chem Commun (Camb). 2007.
Sulzer-Mossé, S., & Alexakis, A. (2007). Chiral amines as organocatalysts for asymmetric conjugate addition to nitroolefins and vinyl sulfones via enamine activation. Chemical Communications (Cambridge, England), (30), 3123-35.
Sulzer-Mossé S, Alexakis A. Chiral Amines as Organocatalysts for Asymmetric Conjugate Addition to Nitroolefins and Vinyl Sulfones Via Enamine Activation. Chem Commun (Camb). 2007 Aug 14;(30)3123-35. PubMed PMID: 17653365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chiral amines as organocatalysts for asymmetric conjugate addition to nitroolefins and vinyl sulfones via enamine activation. AU - Sulzer-Mossé,Sarah, AU - Alexakis,Alexandre, Y1 - 2007/03/21/ PY - 2007/7/27/pubmed PY - 2007/9/12/medline PY - 2007/7/27/entrez SP - 3123 EP - 35 JF - Chemical communications (Cambridge, England) JO - Chem Commun (Camb) IS - 30 N2 - Over the last decade the potential of organocatalysis has successfully been demonstrated. In particular, chiral amines such as pyrrolidine analogues have emerged as a broadly applicable class of organocatalyst for asymmetric conjugate addition via enamine activation. This Feature Article documents the development of these catalysts, emphasizing the design and mechanistic features that supply high selectivity in asymmetric Michael reactions. SN - 1359-7345 UR - https://www.unboundmedicine.com/medline/citation/17653365/Chiral_amines_as_organocatalysts_for_asymmetric_conjugate_addition_to_nitroolefins_and_vinyl_sulfones_via_enamine_activation_ L2 - https://doi.org/10.1039/b701216k DB - PRIME DP - Unbound Medicine ER -