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[Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients].

Abstract

The efficacy and safety of N-acetylcysteine prescribed in general practice were investigated.

METHOD

open, non-controlled surveillance study conducted at 744 centers.

PATIENTS

3,076 patients suffering from bronchitis.

MEDICATION

600 mg N-acetylcysteine (Fluimucil-Long, Inpharzam Germany), administered as a single daily dose.

END POINTS

evaluation of coughing, amount and quality of sputum, expectoration, dyspnea, compliance and tolerance.

RESULTS

impressive improvement of the symptom complex, good compliance. Adverse reactions were reported in 45 patients (rate: 1.5%).

CONCLUSIONS

treatment of chronic and acute bronchitis with the mucolytic agent N-acetylcysteine administered once daily, proved to be both effective and well tolerated.

Authors+Show Affiliations

Gerards HH

Inpharzam GmbH, Gräfelfing.

Vits U

Source

Fortschritte der Medizin 109:34 1991 Nov 30 pg 707-10

MeSH

Acetylcysteine
Administration, Oral
Bronchitis
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Pilot Projects

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

1765342

Citation

Gerards, H H., and U Vits. "[Therapy of Bronchitis. Successful Single-dosage Treatment With N-acetylcysteine, Results of an Administration Surveillance Study in 3,076 Patients]." Fortschritte Der Medizin, vol. 109, no. 34, 1991, pp. 707-10. Unbound PRIME, www.unboundmedicine.com/medline/citation/1765342/. Accessed February 17, 2019.

Gerards HH, Vits U. [Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. Fortschr Med. 1991;109(34):707-10.  https://www.unboundmedicine.com/medline/citation/1765342/. Accessed February 17, 2019.

Gerards, H. H., & Vits, U. (1991). [Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. Fortschritte Der Medizin, 109(34), pp. 707-10. Retrieved from https://www.unboundmedicine.com/medline/citation/1765342/

Gerards HH, Vits U. [Therapy of Bronchitis. Successful Single-dosage Treatment With N-acetylcysteine, Results of an Administration Surveillance Study in 3,076 Patients] [Internet]. Fortschr Med. 1991 Nov 30 [cited 2019 Feb 17];109(34):707-10. Available from: https://www.unboundmedicine.com/medline/citation/1765342/

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - [Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. AU - Gerards,H H, AU - Vits,U, PY - 1991/11/30/pubmed PY - 1991/11/30/medline PY - 1991/11/30/entrez SP - 707 EP - 10 JF - Fortschritte der Medizin JO - Fortschr. Med. VL - 109 IS - 34 N2 - UNLABELLED: The efficacy and safety of N-acetylcysteine prescribed in general practice were investigated. METHOD: open, non-controlled surveillance study conducted at 744 centers. PATIENTS: 3,076 patients suffering from bronchitis. MEDICATION: 600 mg N-acetylcysteine (Fluimucil-Long, Inpharzam Germany), administered as a single daily dose. END POINTS: evaluation of coughing, amount and quality of sputum, expectoration, dyspnea, compliance and tolerance. RESULTS: impressive improvement of the symptom complex, good compliance. Adverse reactions were reported in 45 patients (rate: 1.5%). CONCLUSIONS: treatment of chronic and acute bronchitis with the mucolytic agent N-acetylcysteine administered once daily, proved to be both effective and well tolerated. SN - 0015-8178 UR - https://www.unboundmedicine.com/medline/citation/1765342/ L2 - https://medlineplus.gov/acutebronchitis.html DB - PRIME DP - Unbound Medicine ER -