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Effect of three doses of conjugated estrogens/medroxyprogesterone acetate on biomarkers of bone turnover and cartilage degradation in postmenopausal women: The Pan-Asia Menopause (PAM) study.
Climacteric. 2007 Aug; 10(4):306-13.C

Abstract

OBJECTIVE

To assess the effects of three doses of continuously combined conjugated estrogens (CE) and medroxyprogesterone acetate (MPA) on bone turnover and cartilage degradation markers in early postmenopausal Asian women (mean age 53.6 years).

METHODS

A total of 1028 women were randomly allocated to receive treatment with either 0.625/2.5, 0.45/1.5, or 0.3/1.5 mg CE/MPA for 6 months. End-points were the percent change from baseline in markers of bone resorption (alpha alpha CTX, beta beta CTX), bone formation (osteocalcin), and cartilage degradation (CTX-II).

RESULTS

The 0.45/1.5 mg and the 0.625/2.5 mg doses elicited comparable responses as measured by the biomarkers. Women with high rates of bone or cartilage turnover at baseline responded with larger changes to the effects of CE/MPA.

CONCLUSIONS

Lowering the commonly used dose of 0.625 mg CE + 2.5 mg MPA to 0.45 mg CE + 1.5 mg MPA does not significantly alter the inhibitory effect on bone and cartilage turnover in Asian women.

Authors+Show Affiliations

Wyeth Pharmaceuticals, Collegeville, Pennsylvania, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

17653957

Citation

Ausmanas, M K., et al. "Effect of Three Doses of Conjugated Estrogens/medroxyprogesterone Acetate On Biomarkers of Bone Turnover and Cartilage Degradation in Postmenopausal Women: the Pan-Asia Menopause (PAM) Study." Climacteric : the Journal of the International Menopause Society, vol. 10, no. 4, 2007, pp. 306-13.
Ausmanas MK, Holinka CF, Ling YS, et al. Effect of three doses of conjugated estrogens/medroxyprogesterone acetate on biomarkers of bone turnover and cartilage degradation in postmenopausal women: The Pan-Asia Menopause (PAM) study. Climacteric. 2007;10(4):306-13.
Ausmanas, M. K., Holinka, C. F., Ling, Y. S., & Christiansen, C. (2007). Effect of three doses of conjugated estrogens/medroxyprogesterone acetate on biomarkers of bone turnover and cartilage degradation in postmenopausal women: The Pan-Asia Menopause (PAM) study. Climacteric : the Journal of the International Menopause Society, 10(4), 306-13.
Ausmanas MK, et al. Effect of Three Doses of Conjugated Estrogens/medroxyprogesterone Acetate On Biomarkers of Bone Turnover and Cartilage Degradation in Postmenopausal Women: the Pan-Asia Menopause (PAM) Study. Climacteric. 2007;10(4):306-13. PubMed PMID: 17653957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of three doses of conjugated estrogens/medroxyprogesterone acetate on biomarkers of bone turnover and cartilage degradation in postmenopausal women: The Pan-Asia Menopause (PAM) study. AU - Ausmanas,M K, AU - Holinka,C F, AU - Ling,Y S, AU - Christiansen,C, PY - 2007/7/27/pubmed PY - 2007/11/9/medline PY - 2007/7/27/entrez SP - 306 EP - 13 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 10 IS - 4 N2 - OBJECTIVE: To assess the effects of three doses of continuously combined conjugated estrogens (CE) and medroxyprogesterone acetate (MPA) on bone turnover and cartilage degradation markers in early postmenopausal Asian women (mean age 53.6 years). METHODS: A total of 1028 women were randomly allocated to receive treatment with either 0.625/2.5, 0.45/1.5, or 0.3/1.5 mg CE/MPA for 6 months. End-points were the percent change from baseline in markers of bone resorption (alpha alpha CTX, beta beta CTX), bone formation (osteocalcin), and cartilage degradation (CTX-II). RESULTS: The 0.45/1.5 mg and the 0.625/2.5 mg doses elicited comparable responses as measured by the biomarkers. Women with high rates of bone or cartilage turnover at baseline responded with larger changes to the effects of CE/MPA. CONCLUSIONS: Lowering the commonly used dose of 0.625 mg CE + 2.5 mg MPA to 0.45 mg CE + 1.5 mg MPA does not significantly alter the inhibitory effect on bone and cartilage turnover in Asian women. SN - 1369-7137 UR - https://www.unboundmedicine.com/medline/citation/17653957/Effect_of_three_doses_of_conjugated_estrogens/medroxyprogesterone_acetate_on_biomarkers_of_bone_turnover_and_cartilage_degradation_in_postmenopausal_women:_The_Pan_Asia_Menopause__PAM__study_ L2 - https://www.tandfonline.com/doi/full/10.1080/13697130701463594 DB - PRIME DP - Unbound Medicine ER -