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Homocysteine and cardiovascular disease: a review of the evidence.
Diab Vasc Dis Res. 2007 Jun; 4(2):143-50.DV

Abstract

Elevated homocysteine (HCY) levels can be caused by a number of factors, including folate and B-vitamin deficiency, pre-existing atherosclerotic disease, diabetes and various drugs. Epidemiological evidence, as well as data from retrospective and prospective studies, supports an association between elevated HCY levels and increased risk of cardiovascular disease (CVD). However, whether lowering HCY levels by administration of folate and vitamins B6 and B12 is associated with any significant decrease in vascular risk remains the subject of ongoing debate. Although the major studies that have reported to date show that vitamin supplementation was associated with a decrease in HCY levels, this failed to have any significant effect on cardiovascular risk. Furthermore, although some lipid-modifying treatments have been shown to increase HCY levels, there is no evidence that this attenuates or compromises the beneficial effects of such treatments on cardiovascular risk. Taken together, these data suggest that HCY is a marker, rather than a cause, of CVD and therefore do not provide support for routine screening for and treatment of elevated HCY to prevent CVD. Data from ongoing clinical trials are awaited to clarify this issue.

Authors+Show Affiliations

St Thomas' Hospital, Lambeth Palace Road, London, UK. Anthony.Wierzbicki@kcl.ac.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17654449

Citation

Wierzbicki, Anthony S.. "Homocysteine and Cardiovascular Disease: a Review of the Evidence." Diabetes & Vascular Disease Research, vol. 4, no. 2, 2007, pp. 143-50.
Wierzbicki AS. Homocysteine and cardiovascular disease: a review of the evidence. Diab Vasc Dis Res. 2007;4(2):143-50.
Wierzbicki, A. S. (2007). Homocysteine and cardiovascular disease: a review of the evidence. Diabetes & Vascular Disease Research, 4(2), 143-50.
Wierzbicki AS. Homocysteine and Cardiovascular Disease: a Review of the Evidence. Diab Vasc Dis Res. 2007;4(2):143-50. PubMed PMID: 17654449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine and cardiovascular disease: a review of the evidence. A1 - Wierzbicki,Anthony S, PY - 2007/7/27/pubmed PY - 2007/9/19/medline PY - 2007/7/27/entrez SP - 143 EP - 50 JF - Diabetes & vascular disease research JO - Diab Vasc Dis Res VL - 4 IS - 2 N2 - Elevated homocysteine (HCY) levels can be caused by a number of factors, including folate and B-vitamin deficiency, pre-existing atherosclerotic disease, diabetes and various drugs. Epidemiological evidence, as well as data from retrospective and prospective studies, supports an association between elevated HCY levels and increased risk of cardiovascular disease (CVD). However, whether lowering HCY levels by administration of folate and vitamins B6 and B12 is associated with any significant decrease in vascular risk remains the subject of ongoing debate. Although the major studies that have reported to date show that vitamin supplementation was associated with a decrease in HCY levels, this failed to have any significant effect on cardiovascular risk. Furthermore, although some lipid-modifying treatments have been shown to increase HCY levels, there is no evidence that this attenuates or compromises the beneficial effects of such treatments on cardiovascular risk. Taken together, these data suggest that HCY is a marker, rather than a cause, of CVD and therefore do not provide support for routine screening for and treatment of elevated HCY to prevent CVD. Data from ongoing clinical trials are awaited to clarify this issue. SN - 1479-1641 UR - https://www.unboundmedicine.com/medline/citation/17654449/Homocysteine_and_cardiovascular_disease:_a_review_of_the_evidence_ L2 - http://journals.sagepub.com/doi/full/10.3132/dvdr.2007.033?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -