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Chemical composition and biological activity of a new type of Brazilian propolis: red propolis.
J Ethnopharmacol. 2007 Sep 05; 113(2):278-83.JE

Abstract

Propolis has been used as a medicinal agent to treat infections and promote wound healing for centuries. The aim of the present study was to test the antimicrobial, antioxidant, and cytotoxic activities of a new type of Brazilian propolis, popularly called red propolis, as well as to analyze its chemical composition. The antimicrobial activity against Staphylococcus aureus ATCC 25923 and Staphylococcus mutans UA159 was evaluated and the chloroform fraction (Chlo-fr) was the most active with lower MIC ranging from 25 to 50 microg/ml. The hexane fraction (H-fr), having the highest concentration of total flavonoids, showed the best sequestrating activity for the free radical DPPH. The ethanolic extract of propolis (EEP) showed cytotoxic activity for the HeLa tumor cells with an IC(50) of 7.45 microg/ml. When the EEP was analyzed by GC-MS, seven new compounds were found, among which four were isoflavones. Our results showed that the red propolis has biologically active compounds that had never been reported in other types of Brazilian propolis.

Authors+Show Affiliations

Department of Agri-Food industry, Food and Nutrition, Luiz de Queiroz College of Agriculture, University of São Paulo, Avenida Pádua Dias 11, Piracicaba, CEP 13418-900, SP, Brazil. alenca@easlq.usp.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17656055

Citation

Alencar, S M., et al. "Chemical Composition and Biological Activity of a New Type of Brazilian Propolis: Red Propolis." Journal of Ethnopharmacology, vol. 113, no. 2, 2007, pp. 278-83.
Alencar SM, Oldoni TL, Castro ML, et al. Chemical composition and biological activity of a new type of Brazilian propolis: red propolis. J Ethnopharmacol. 2007;113(2):278-83.
Alencar, S. M., Oldoni, T. L., Castro, M. L., Cabral, I. S., Costa-Neto, C. M., Cury, J. A., Rosalen, P. L., & Ikegaki, M. (2007). Chemical composition and biological activity of a new type of Brazilian propolis: red propolis. Journal of Ethnopharmacology, 113(2), 278-83.
Alencar SM, et al. Chemical Composition and Biological Activity of a New Type of Brazilian Propolis: Red Propolis. J Ethnopharmacol. 2007 Sep 5;113(2):278-83. PubMed PMID: 17656055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and biological activity of a new type of Brazilian propolis: red propolis. AU - Alencar,S M, AU - Oldoni,T L C, AU - Castro,M L, AU - Cabral,I S R, AU - Costa-Neto,C M, AU - Cury,J A, AU - Rosalen,P L, AU - Ikegaki,M, Y1 - 2007/06/23/ PY - 2006/07/26/received PY - 2007/05/31/revised PY - 2007/06/18/accepted PY - 2007/7/28/pubmed PY - 2007/12/28/medline PY - 2007/7/28/entrez SP - 278 EP - 83 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 113 IS - 2 N2 - Propolis has been used as a medicinal agent to treat infections and promote wound healing for centuries. The aim of the present study was to test the antimicrobial, antioxidant, and cytotoxic activities of a new type of Brazilian propolis, popularly called red propolis, as well as to analyze its chemical composition. The antimicrobial activity against Staphylococcus aureus ATCC 25923 and Staphylococcus mutans UA159 was evaluated and the chloroform fraction (Chlo-fr) was the most active with lower MIC ranging from 25 to 50 microg/ml. The hexane fraction (H-fr), having the highest concentration of total flavonoids, showed the best sequestrating activity for the free radical DPPH. The ethanolic extract of propolis (EEP) showed cytotoxic activity for the HeLa tumor cells with an IC(50) of 7.45 microg/ml. When the EEP was analyzed by GC-MS, seven new compounds were found, among which four were isoflavones. Our results showed that the red propolis has biologically active compounds that had never been reported in other types of Brazilian propolis. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17656055/Chemical_composition_and_biological_activity_of_a_new_type_of_Brazilian_propolis:_red_propolis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00284-X DB - PRIME DP - Unbound Medicine ER -