Tags

Type your tag names separated by a space and hit enter

Short interval intracortical inhibition and facilitation during the silent period in human.
J Physiol. 2007 Sep 15; 583(Pt 3):971-82.JP

Abstract

Following a suprathreshold transcranial magnetic stimulation (TMS) to the primary motor cortex (M1) during voluntary muscle contraction, a motor evoked potential (MEP) occurs in the target muscle followed by a silent period (SP) in the electromyographic (EMG) activities. The present study investigated how short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) change during the SP. The time course of MEP and motor threshold during the SP were examined in the right first dorsal interosseous muscle. Using a triple-pulse protocol, SICI and ICF were tested at different times during the SP. The effects of different intensities of the conditioning stimulation (CS) for SICI and ICF were also investigated during the SP and at rest. During the SP, MEP was inhibited and motor threshold was increased, whereas MEP latency and background EMG level were same as those at rest. SICI decreased during the SP over a wide range of CS intensities. ICF increased at higher CS intensity. We conclude that SICI is suppressed and ICF is facilitated during the SP and the effects are separate from the interruption of voluntary drive.

Authors+Show Affiliations

Division of Neurology, Krembil Neuroscience Centre, University of Toronto, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17656435

Citation

Ni, Zhen, et al. "Short Interval Intracortical Inhibition and Facilitation During the Silent Period in Human." The Journal of Physiology, vol. 583, no. Pt 3, 2007, pp. 971-82.
Ni Z, Gunraj C, Chen R. Short interval intracortical inhibition and facilitation during the silent period in human. J Physiol. 2007;583(Pt 3):971-82.
Ni, Z., Gunraj, C., & Chen, R. (2007). Short interval intracortical inhibition and facilitation during the silent period in human. The Journal of Physiology, 583(Pt 3), 971-82.
Ni Z, Gunraj C, Chen R. Short Interval Intracortical Inhibition and Facilitation During the Silent Period in Human. J Physiol. 2007 Sep 15;583(Pt 3):971-82. PubMed PMID: 17656435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short interval intracortical inhibition and facilitation during the silent period in human. AU - Ni,Zhen, AU - Gunraj,Carolyn, AU - Chen,Robert, Y1 - 2007/07/26/ PY - 2007/7/28/pubmed PY - 2007/12/7/medline PY - 2007/7/28/entrez SP - 971 EP - 82 JF - The Journal of physiology JO - J Physiol VL - 583 IS - Pt 3 N2 - Following a suprathreshold transcranial magnetic stimulation (TMS) to the primary motor cortex (M1) during voluntary muscle contraction, a motor evoked potential (MEP) occurs in the target muscle followed by a silent period (SP) in the electromyographic (EMG) activities. The present study investigated how short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) change during the SP. The time course of MEP and motor threshold during the SP were examined in the right first dorsal interosseous muscle. Using a triple-pulse protocol, SICI and ICF were tested at different times during the SP. The effects of different intensities of the conditioning stimulation (CS) for SICI and ICF were also investigated during the SP and at rest. During the SP, MEP was inhibited and motor threshold was increased, whereas MEP latency and background EMG level were same as those at rest. SICI decreased during the SP over a wide range of CS intensities. ICF increased at higher CS intensity. We conclude that SICI is suppressed and ICF is facilitated during the SP and the effects are separate from the interruption of voluntary drive. SN - 0022-3751 UR - https://www.unboundmedicine.com/medline/citation/17656435/Short_interval_intracortical_inhibition_and_facilitation_during_the_silent_period_in_human_ L2 - https://doi.org/10.1113/jphysiol.2007.135749 DB - PRIME DP - Unbound Medicine ER -