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Carotid intima-media thickness in confirmed prehypertensive subjects: predictors and progression.

Abstract

OBJECTIVE

The purpose of this study was to test whether carotid intima-media thickness (IMT) is already increased in normotensive subjects who progress to hypertension (confirmed prehypertensives) independently of known determinants of vessel wall thickness.

METHODS AND RESULTS

Common carotid artery (CCA) far-wall IMT was measured (B-mode ultrasound) in 1536 subjects from the population-based Mexico City Diabetes Study at baseline and 3.5 years later. In the 136 confirmed prehypertensives, CCA-IMT (720 [253] microm, median[interquartile range]) was intermediate between normotensives (615 [140] microm) and hypertensives (725 [215] microm). After multiadjusting for gender, age, BMI, blood pressure, total cholesterol, antihypertensive therapy, and diabetes, converter status was independently associated with a higher CCA-IMT (+93+/-14 microm). At follow-up, CCA-IMT increased by 35 [180] microm. Gender, age, blood pressure, and presence of diabetes, but not the converter status, were significant independent predictors of CCA-IMT progression. In a model adjusting for gender, age, blood pressure (level, status and treatment), diabetes status, total and HDL-cholesterol, the G variant of the 45T/G polymorphism of the adiponectin gene was associated with a hazard ratio of 1.45 (95% CI: 1.04 to 2.01) of a baseline CCA-IMT in the top quintile.

CONCLUSIONS

In confirmed prehypertensives, CCA-IMT is increased independently of blood pressure and known determinants of wall thickness, but short-term CCA-IMT progression is not accelerated.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine and Metabolism Unit of the C.N.R. Institute of Clinical Physiology.

    , , , , ,

    Source

    MeSH

    Adiponectin
    Adult
    Carotid Artery Diseases
    Carotid Artery, Common
    Databases as Topic
    Disease Progression
    Female
    Follow-Up Studies
    Genetic Predisposition to Disease
    Humans
    Hypertension
    Logistic Models
    Longitudinal Studies
    Male
    Mexico
    Middle Aged
    Polymorphism, Genetic
    Risk Assessment
    Risk Factors
    Time Factors
    Tunica Intima
    Tunica Media
    Ultrasonography

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17656672

    Citation

    Femia, Romana, et al. "Carotid Intima-media Thickness in Confirmed Prehypertensive Subjects: Predictors and Progression." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 10, 2007, pp. 2244-9.
    Femia R, Kozakova M, Nannipieri M, et al. Carotid intima-media thickness in confirmed prehypertensive subjects: predictors and progression. Arterioscler Thromb Vasc Biol. 2007;27(10):2244-9.
    Femia, R., Kozakova, M., Nannipieri, M., Gonzales-Villalpando, C., Stern, M. P., Haffner, S. M., & Ferrannini, E. (2007). Carotid intima-media thickness in confirmed prehypertensive subjects: predictors and progression. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(10), pp. 2244-9.
    Femia R, et al. Carotid Intima-media Thickness in Confirmed Prehypertensive Subjects: Predictors and Progression. Arterioscler Thromb Vasc Biol. 2007;27(10):2244-9. PubMed PMID: 17656672.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Carotid intima-media thickness in confirmed prehypertensive subjects: predictors and progression. AU - Femia,Romana, AU - Kozakova,Michaela, AU - Nannipieri,Monica, AU - Gonzales-Villalpando,Clicerio, AU - Stern,Michael P, AU - Haffner,Steven M, AU - Ferrannini,Ele, Y1 - 2007/07/26/ PY - 2007/7/28/pubmed PY - 2007/10/12/medline PY - 2007/7/28/entrez SP - 2244 EP - 9 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 27 IS - 10 N2 - OBJECTIVE: The purpose of this study was to test whether carotid intima-media thickness (IMT) is already increased in normotensive subjects who progress to hypertension (confirmed prehypertensives) independently of known determinants of vessel wall thickness. METHODS AND RESULTS: Common carotid artery (CCA) far-wall IMT was measured (B-mode ultrasound) in 1536 subjects from the population-based Mexico City Diabetes Study at baseline and 3.5 years later. In the 136 confirmed prehypertensives, CCA-IMT (720 [253] microm, median[interquartile range]) was intermediate between normotensives (615 [140] microm) and hypertensives (725 [215] microm). After multiadjusting for gender, age, BMI, blood pressure, total cholesterol, antihypertensive therapy, and diabetes, converter status was independently associated with a higher CCA-IMT (+93+/-14 microm). At follow-up, CCA-IMT increased by 35 [180] microm. Gender, age, blood pressure, and presence of diabetes, but not the converter status, were significant independent predictors of CCA-IMT progression. In a model adjusting for gender, age, blood pressure (level, status and treatment), diabetes status, total and HDL-cholesterol, the G variant of the 45T/G polymorphism of the adiponectin gene was associated with a hazard ratio of 1.45 (95% CI: 1.04 to 2.01) of a baseline CCA-IMT in the top quintile. CONCLUSIONS: In confirmed prehypertensives, CCA-IMT is increased independently of blood pressure and known determinants of wall thickness, but short-term CCA-IMT progression is not accelerated. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/17656672/Carotid_intima_media_thickness_in_confirmed_prehypertensive_subjects:_predictors_and_progression_ L2 - http://www.ahajournals.org/doi/full/10.1161/ATVBAHA.107.149641?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -