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Alteration of peripheral markers of copper homeostasis in Alzheimer's disease patients: implications in aetiology and therapy.

Abstract

Alzheimer's disease represents a growing health problem because of the ongoing increase in life expectancy. Therefore understanding the molecular alterations responsible for neurodegeneration has become imperative in order to develop efficient strategies for the therapy. Mounting evidence suggests that the essential metal ion copper is intriguingly connected with the established molecular markers of Alzheimer's disease and that copper homeostasis is disturbed in affected individuals, leading to oxidative stress and neurodegeneration. This review summarizes the mechanisms of copper trafficking in cells and describes the relationship between copper, the amyloid precursor protein and beta-amyloid. Since one of the main goals of the research on Alzheimer's disease is the identification of blood markers to aid diagnosis and monitor the effects of therapeutic approaches, the results obtained in a series of studies on copper in the blood of Alzheimer's disease patients recently carried out in our laboratories are described.

Authors+Show Affiliations

,

Department of Biology Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy. luisa.rossi@uniroma2.it

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Source

MeSH

Aged
Aging
Alzheimer Disease
Amyloid beta-Peptides
Biomarkers
Brain
Copper
Female
Homeostasis
Humans
Male
Oxidative Stress

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17657362

Citation

Rossi, L, et al. "Alteration of Peripheral Markers of Copper Homeostasis in Alzheimer's Disease Patients: Implications in Aetiology and Therapy." The Journal of Nutrition, Health & Aging, vol. 11, no. 5, 2007, pp. 408-17.
Rossi L, Squitti R, Calabrese L, et al. Alteration of peripheral markers of copper homeostasis in Alzheimer's disease patients: implications in aetiology and therapy. J Nutr Health Aging. 2007;11(5):408-17.
Rossi, L., Squitti, R., Calabrese, L., Rotilio, G., & Rossini, P. M. (2007). Alteration of peripheral markers of copper homeostasis in Alzheimer's disease patients: implications in aetiology and therapy. The Journal of Nutrition, Health & Aging, 11(5), pp. 408-17.
Rossi L, et al. Alteration of Peripheral Markers of Copper Homeostasis in Alzheimer's Disease Patients: Implications in Aetiology and Therapy. J Nutr Health Aging. 2007;11(5):408-17. PubMed PMID: 17657362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alteration of peripheral markers of copper homeostasis in Alzheimer's disease patients: implications in aetiology and therapy. AU - Rossi,L, AU - Squitti,R, AU - Calabrese,L, AU - Rotilio,G, AU - Rossini,P M, PY - 2007/7/28/pubmed PY - 2007/12/6/medline PY - 2007/7/28/entrez SP - 408 EP - 17 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 11 IS - 5 N2 - Alzheimer's disease represents a growing health problem because of the ongoing increase in life expectancy. Therefore understanding the molecular alterations responsible for neurodegeneration has become imperative in order to develop efficient strategies for the therapy. Mounting evidence suggests that the essential metal ion copper is intriguingly connected with the established molecular markers of Alzheimer's disease and that copper homeostasis is disturbed in affected individuals, leading to oxidative stress and neurodegeneration. This review summarizes the mechanisms of copper trafficking in cells and describes the relationship between copper, the amyloid precursor protein and beta-amyloid. Since one of the main goals of the research on Alzheimer's disease is the identification of blood markers to aid diagnosis and monitor the effects of therapeutic approaches, the results obtained in a series of studies on copper in the blood of Alzheimer's disease patients recently carried out in our laboratories are described. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/17657362/Alteration_of_peripheral_markers_of_copper_homeostasis_in_Alzheimer's_disease_patients:_implications_in_aetiology_and_therapy_ L2 - https://medlineplus.gov/seniorshealth.html DB - PRIME DP - Unbound Medicine ER -