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Relationship between hyperuricemia and metabolic syndrome.
J Zhejiang Univ Sci B. 2007 Aug; 8(8):593-8.JZ

Abstract

OBJECTIVE

To investigate the relationship between metabolic syndrome and hyperuricemia.

METHODS

A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as >or=7 mg/dl (in men) or >or=6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria.

RESULTS

(1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia [odds ratio (OR)=1.634, P=0.000]. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia.

CONCLUSION

Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome.

Authors+Show Affiliations

Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. cly0906@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17657863

Citation

Chen, Li-ying, et al. "Relationship Between Hyperuricemia and Metabolic Syndrome." Journal of Zhejiang University. Science. B, vol. 8, no. 8, 2007, pp. 593-8.
Chen LY, Zhu WH, Chen ZW, et al. Relationship between hyperuricemia and metabolic syndrome. J Zhejiang Univ Sci B. 2007;8(8):593-8.
Chen, L. Y., Zhu, W. H., Chen, Z. W., Dai, H. L., Ren, J. J., Chen, J. H., Chen, L. Q., & Fang, L. Z. (2007). Relationship between hyperuricemia and metabolic syndrome. Journal of Zhejiang University. Science. B, 8(8), 593-8.
Chen LY, et al. Relationship Between Hyperuricemia and Metabolic Syndrome. J Zhejiang Univ Sci B. 2007;8(8):593-8. PubMed PMID: 17657863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between hyperuricemia and metabolic syndrome. AU - Chen,Li-ying, AU - Zhu,Wen-hua, AU - Chen,Zhou-wen, AU - Dai,Hong-lei, AU - Ren,Jing-jing, AU - Chen,Jian-hua, AU - Chen,Lei-qian, AU - Fang,Li-zheng, PY - 2007/7/28/pubmed PY - 2007/9/29/medline PY - 2007/7/28/entrez SP - 593 EP - 8 JF - Journal of Zhejiang University. Science. B JO - J Zhejiang Univ Sci B VL - 8 IS - 8 N2 - OBJECTIVE: To investigate the relationship between metabolic syndrome and hyperuricemia. METHODS: A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as >or=7 mg/dl (in men) or >or=6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. RESULTS: (1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia [odds ratio (OR)=1.634, P=0.000]. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia. CONCLUSION: Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome. SN - 1673-1581 UR - https://www.unboundmedicine.com/medline/citation/17657863/Relationship_between_hyperuricemia_and_metabolic_syndrome_ L2 - http://www.jzus.zju.edu.cn/article.php?doi=10.1631/jzus.2007.B0593 DB - PRIME DP - Unbound Medicine ER -