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Pathogenesis and clinical features of psoriasis.

Abstract

Psoriasis, a papulosquamous skin disease, was originally thought of as a disorder primarily of epidermal keratinocytes, but is now recognised as one of the commonest immune-mediated disorders. Tumour necrosis factor alpha, dendritic cells, and T-cells all contribute substantially to its pathogenesis. In early-onset psoriasis (beginning before age 40 years), carriage of HLA-Cw6 and environmental triggers, such as beta-haemolytic streptococcal infections, are major determinants of disease expression. Moreover, at least nine chromosomal psoriasis susceptibility loci have been identified. Several clinical phenotypes of psoriasis are recognised, with chronic plaque (psoriasis vulgaris) accounting for 90% of cases. Comorbidities of psoriasis are attracting interest, and include impairment of quality of life and associated depressive illness, cardiovascular disease, and a seronegative arthritis known as psoriatic arthritis. A more complete understanding of underlying pathomechanisms is leading to new treatments, which will be discussed in the second part of this Series.

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  • Authors+Show Affiliations

    ,

    Dermatology Centre, Hope Hospital, University of Manchester, Manchester M6 8HD, UK. Electronic address: christopher.griffiths@manchester.ac.uk.

    St John's Institute of Dermatology, Guy's Hospital Campus, King's College London, London, UK.

    Source

    Lancet (London, England) 370:9583 2007 Jul 21 pg 263-271

    MeSH

    Animals
    Comorbidity
    Disease Models, Animal
    Female
    Humans
    Male
    Psoriasis
    Social Isolation

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    17658397

    Citation

    Griffiths, Christopher Em, and Jonathan Nwn Barker. "Pathogenesis and Clinical Features of Psoriasis." Lancet (London, England), vol. 370, no. 9583, 2007, pp. 263-271.
    Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007;370(9583):263-271.
    Griffiths, C. E., & Barker, J. N. (2007). Pathogenesis and clinical features of psoriasis. Lancet (London, England), 370(9583), pp. 263-271. doi:10.1016/S0140-6736(07)61128-3.
    Griffiths CE, Barker JN. Pathogenesis and Clinical Features of Psoriasis. Lancet. 2007 Jul 21;370(9583):263-271. PubMed PMID: 17658397.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pathogenesis and clinical features of psoriasis. AU - Griffiths,Christopher Em, AU - Barker,Jonathan Nwn, PY - 2007/7/31/pubmed PY - 2007/8/10/medline PY - 2007/7/31/entrez SP - 263 EP - 271 JF - Lancet (London, England) JO - Lancet VL - 370 IS - 9583 N2 - Psoriasis, a papulosquamous skin disease, was originally thought of as a disorder primarily of epidermal keratinocytes, but is now recognised as one of the commonest immune-mediated disorders. Tumour necrosis factor alpha, dendritic cells, and T-cells all contribute substantially to its pathogenesis. In early-onset psoriasis (beginning before age 40 years), carriage of HLA-Cw6 and environmental triggers, such as beta-haemolytic streptococcal infections, are major determinants of disease expression. Moreover, at least nine chromosomal psoriasis susceptibility loci have been identified. Several clinical phenotypes of psoriasis are recognised, with chronic plaque (psoriasis vulgaris) accounting for 90% of cases. Comorbidities of psoriasis are attracting interest, and include impairment of quality of life and associated depressive illness, cardiovascular disease, and a seronegative arthritis known as psoriatic arthritis. A more complete understanding of underlying pathomechanisms is leading to new treatments, which will be discussed in the second part of this Series. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/17658397/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(07)61128-3 DB - PRIME DP - Unbound Medicine ER -