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Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients.
Fertil Steril. 2008 Jun; 89(6):1670-6.FS

Abstract

OBJECTIVE

To measure serum anti-Müllerian hormone (AMH) during different phases of the menstrual cycle and to correlate the measurements with ovarian response and clinical-pregnancy rates in intracytoplasmic sperm injection cycles.

DESIGN

Prospective cohort study.

SETTING

University IVF unit.

PATIENT(S)

Thirty-three patients undergoing their first intracytoplasmic sperm injection treatment cycle with a long protocol.

INTERVENTION(S)

On day 3 of the menstrual cycle, measurements of AMH, FSH, and LH and ultrasound evaluation of mean ovarian volume and antral follicle count were performed. Anti-Müllerian hormone was remeasured at ovulation and 7-8 days later (midluteal).

MAIN OUTCOME MEASURE(S)

Poor response and number of oocytes were primary outcomes. Clinical pregnancy was a secondary outcome.

RESULT(S)

Levels of AMH were lower in poor ovarian responders than in normal responders. Number of oocytes retrieved was statistically significantly correlated with midluteal AMH, day 3 AMH, antral follicle count, ovulatory AMH, mean ovarian volume (r = 0.89, 0.88, 0.88, 0.86, 0.66, respectively) and with day 3 FSH (r = -0.41). Midluteal, day 3, and ovulatory AMH showed a good discriminatory potential for prediction of poor response (area under the receiver operating characteristics curves, 0.977, 0.9, and 0.89, respectively). Midluteal and early AMH were statistically significant predictors of clinical pregnancy.

CONCLUSION(S)

A strong association exists between midluteal, early follicular, ovulatory AMH levels and number of oocytes retrieved. Midluteal and early follicular AMH may offer good prognostic value for clinical pregnancy.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, the University of Zagazig, Zagazig, Egypt.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17658520

Citation

Elgindy, Eman A., et al. "Anti-Müllerian Hormone: Correlation of Early Follicular, Ovulatory and Midluteal Levels With Ovarian Response and Cycle Outcome in Intracytoplasmic Sperm Injection Patients." Fertility and Sterility, vol. 89, no. 6, 2008, pp. 1670-6.
Elgindy EA, El-Haieg DO, El-Sebaey A. Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients. Fertil Steril. 2008;89(6):1670-6.
Elgindy, E. A., El-Haieg, D. O., & El-Sebaey, A. (2008). Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients. Fertility and Sterility, 89(6), 1670-6.
Elgindy EA, El-Haieg DO, El-Sebaey A. Anti-Müllerian Hormone: Correlation of Early Follicular, Ovulatory and Midluteal Levels With Ovarian Response and Cycle Outcome in Intracytoplasmic Sperm Injection Patients. Fertil Steril. 2008;89(6):1670-6. PubMed PMID: 17658520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients. AU - Elgindy,Eman A, AU - El-Haieg,Dahlia O, AU - El-Sebaey,Azza, Y1 - 2007/07/20/ PY - 2007/03/11/received PY - 2007/05/14/revised PY - 2007/05/14/accepted PY - 2007/7/31/pubmed PY - 2008/8/5/medline PY - 2007/7/31/entrez SP - 1670 EP - 6 JF - Fertility and sterility JO - Fertil Steril VL - 89 IS - 6 N2 - OBJECTIVE: To measure serum anti-Müllerian hormone (AMH) during different phases of the menstrual cycle and to correlate the measurements with ovarian response and clinical-pregnancy rates in intracytoplasmic sperm injection cycles. DESIGN: Prospective cohort study. SETTING: University IVF unit. PATIENT(S): Thirty-three patients undergoing their first intracytoplasmic sperm injection treatment cycle with a long protocol. INTERVENTION(S): On day 3 of the menstrual cycle, measurements of AMH, FSH, and LH and ultrasound evaluation of mean ovarian volume and antral follicle count were performed. Anti-Müllerian hormone was remeasured at ovulation and 7-8 days later (midluteal). MAIN OUTCOME MEASURE(S): Poor response and number of oocytes were primary outcomes. Clinical pregnancy was a secondary outcome. RESULT(S): Levels of AMH were lower in poor ovarian responders than in normal responders. Number of oocytes retrieved was statistically significantly correlated with midluteal AMH, day 3 AMH, antral follicle count, ovulatory AMH, mean ovarian volume (r = 0.89, 0.88, 0.88, 0.86, 0.66, respectively) and with day 3 FSH (r = -0.41). Midluteal, day 3, and ovulatory AMH showed a good discriminatory potential for prediction of poor response (area under the receiver operating characteristics curves, 0.977, 0.9, and 0.89, respectively). Midluteal and early AMH were statistically significant predictors of clinical pregnancy. CONCLUSION(S): A strong association exists between midluteal, early follicular, ovulatory AMH levels and number of oocytes retrieved. Midluteal and early follicular AMH may offer good prognostic value for clinical pregnancy. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17658520/Anti_Müllerian_hormone:_correlation_of_early_follicular_ovulatory_and_midluteal_levels_with_ovarian_response_and_cycle_outcome_in_intracytoplasmic_sperm_injection_patients_ DB - PRIME DP - Unbound Medicine ER -