Tags

Type your tag names separated by a space and hit enter

Age at infection affects the pathogenicity of Asian highly pathogenic avian influenza H5N1 viruses in ducks.
Virus Res. 2007 Dec; 130(1-2):151-61.VR

Abstract

The Asian highly pathogenic avian influenza (HPAI) H5N1 viruses have changed from producing no disease or mild respiratory infections in ducks to some strains causing systemic disease and death. Differences in pathogenicity between four of these viruses as well as the effect of host age on the outcome of infection were studied in ducks. Three of the viruses were highly lethal in 2-week-old ducks and induced severe neurological dysfunction. Neurological signs were also observed in 5-week-old ducks inoculated with one of these viruses; however mortality was low. The fourth virus studied did not induce neurological signs in 2-week-old ducks, but did produce moderate mortality. This virus caused no clinical signs or death in 5-week-old ducks. All viruses studied were isolated from oropharyngeal and cloacal swabs, and also from brain, heart, lung and muscle tissues, demonstrating systemic infection. All viruses evaluated transmitted efficiently to contact ducks. Phylogenetic analysis of the viruses studied and other Asian H5N1 HPAI viruses with diverse pathogenicity in ducks, showed changes in several genes, but none clearly associated with pathogenicity. In conclusion, the pathogenicity of circulating H5N1 HPAI viruses in ducks varies depending on the virus strain and the age of the duck and correlates with the level of viral replication in tissues. High titers of virus in organs, high viral shedding, and variable mortality enable ducks to circulate H5N1 HPAI viruses.

Authors+Show Affiliations

Southeast Poultry Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 934 College Station Road, Athens, GA 30605, United States. mpantin-jackwood@seprl.usda.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17658647

Citation

Pantin-Jackwood, M J., et al. "Age at Infection Affects the Pathogenicity of Asian Highly Pathogenic Avian Influenza H5N1 Viruses in Ducks." Virus Research, vol. 130, no. 1-2, 2007, pp. 151-61.
Pantin-Jackwood MJ, Suarez DL, Spackman E, et al. Age at infection affects the pathogenicity of Asian highly pathogenic avian influenza H5N1 viruses in ducks. Virus Res. 2007;130(1-2):151-61.
Pantin-Jackwood, M. J., Suarez, D. L., Spackman, E., & Swayne, D. E. (2007). Age at infection affects the pathogenicity of Asian highly pathogenic avian influenza H5N1 viruses in ducks. Virus Research, 130(1-2), 151-61.
Pantin-Jackwood MJ, et al. Age at Infection Affects the Pathogenicity of Asian Highly Pathogenic Avian Influenza H5N1 Viruses in Ducks. Virus Res. 2007;130(1-2):151-61. PubMed PMID: 17658647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age at infection affects the pathogenicity of Asian highly pathogenic avian influenza H5N1 viruses in ducks. AU - Pantin-Jackwood,M J, AU - Suarez,D L, AU - Spackman,E, AU - Swayne,D E, Y1 - 2007/07/20/ PY - 2007/02/22/received PY - 2007/05/24/revised PY - 2007/06/11/accepted PY - 2007/7/31/pubmed PY - 2008/1/23/medline PY - 2007/7/31/entrez SP - 151 EP - 61 JF - Virus research JO - Virus Res VL - 130 IS - 1-2 N2 - The Asian highly pathogenic avian influenza (HPAI) H5N1 viruses have changed from producing no disease or mild respiratory infections in ducks to some strains causing systemic disease and death. Differences in pathogenicity between four of these viruses as well as the effect of host age on the outcome of infection were studied in ducks. Three of the viruses were highly lethal in 2-week-old ducks and induced severe neurological dysfunction. Neurological signs were also observed in 5-week-old ducks inoculated with one of these viruses; however mortality was low. The fourth virus studied did not induce neurological signs in 2-week-old ducks, but did produce moderate mortality. This virus caused no clinical signs or death in 5-week-old ducks. All viruses studied were isolated from oropharyngeal and cloacal swabs, and also from brain, heart, lung and muscle tissues, demonstrating systemic infection. All viruses evaluated transmitted efficiently to contact ducks. Phylogenetic analysis of the viruses studied and other Asian H5N1 HPAI viruses with diverse pathogenicity in ducks, showed changes in several genes, but none clearly associated with pathogenicity. In conclusion, the pathogenicity of circulating H5N1 HPAI viruses in ducks varies depending on the virus strain and the age of the duck and correlates with the level of viral replication in tissues. High titers of virus in organs, high viral shedding, and variable mortality enable ducks to circulate H5N1 HPAI viruses. SN - 0168-1702 UR - https://www.unboundmedicine.com/medline/citation/17658647/Age_at_infection_affects_the_pathogenicity_of_Asian_highly_pathogenic_avian_influenza_H5N1_viruses_in_ducks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(07)00220-1 DB - PRIME DP - Unbound Medicine ER -