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Enhanced skin blood flow and sensitivity to noxious heat stimuli in papulopustular rosacea.
J Am Acad Dermatol. 2007 Nov; 57(5):800-5.JA

Abstract

BACKGROUND

Although patients with rosacea often complain of increased skin sensitivity, there has been no quantitative sensory testing of this phenomenon. Furthermore, cutaneous blood flow in these patients has not been assessed using state-of-the-art laser Doppler imaging (LDI).

OBJECTIVES

To assess heat pain thresholds and skin blood flow using quantitative thermal sensory testing and LDI in patients with untreated rosacea.

METHODS

Of the total 24 subjects enrolled, 8 had papulopustular rosacea (PPR), 8 had erythematotelangiectatic rosacea (ETR) and 8 were control subjects. Subjective burning perception, heat pain threshold, skin blood flow, and skin temperature was assessed in all subjects. In the ETR and PPR groups, two areas were compared: affected and nonaffected.

RESULTS

Heat pain thresholds of areas affected by rosacea were lower than those of nonaffected areas. In addition, subjective burning perception was increased in rosacea patients when compared with control subjects. Although PPR-affected skin had elevated skin blood flow when compared with nonaffected skin, this was not significant for ETR-affected skin.

LIMITATIONS

The small number of subjects enrolled was the main limitation.

CONCLUSION

This study showed enhanced sensitivity to noxious heat stimuli in rosacea-affected skin, which was more prominent in the PPR group.

Authors+Show Affiliations

Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17658664

Citation

Guzman-Sanchez, Daniela A., et al. "Enhanced Skin Blood Flow and Sensitivity to Noxious Heat Stimuli in Papulopustular Rosacea." Journal of the American Academy of Dermatology, vol. 57, no. 5, 2007, pp. 800-5.
Guzman-Sanchez DA, Ishiuji Y, Patel T, et al. Enhanced skin blood flow and sensitivity to noxious heat stimuli in papulopustular rosacea. J Am Acad Dermatol. 2007;57(5):800-5.
Guzman-Sanchez, D. A., Ishiuji, Y., Patel, T., Fountain, J., Chan, Y. H., & Yosipovitch, G. (2007). Enhanced skin blood flow and sensitivity to noxious heat stimuli in papulopustular rosacea. Journal of the American Academy of Dermatology, 57(5), 800-5.
Guzman-Sanchez DA, et al. Enhanced Skin Blood Flow and Sensitivity to Noxious Heat Stimuli in Papulopustular Rosacea. J Am Acad Dermatol. 2007;57(5):800-5. PubMed PMID: 17658664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced skin blood flow and sensitivity to noxious heat stimuli in papulopustular rosacea. AU - Guzman-Sanchez,Daniela A, AU - Ishiuji,Yozo, AU - Patel,Tejesh, AU - Fountain,Julie, AU - Chan,Yiong Huak, AU - Yosipovitch,Gil, Y1 - 2007/07/20/ PY - 2007/04/02/received PY - 2007/05/23/revised PY - 2007/06/17/accepted PY - 2007/7/31/pubmed PY - 2007/11/9/medline PY - 2007/7/31/entrez SP - 800 EP - 5 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 57 IS - 5 N2 - BACKGROUND: Although patients with rosacea often complain of increased skin sensitivity, there has been no quantitative sensory testing of this phenomenon. Furthermore, cutaneous blood flow in these patients has not been assessed using state-of-the-art laser Doppler imaging (LDI). OBJECTIVES: To assess heat pain thresholds and skin blood flow using quantitative thermal sensory testing and LDI in patients with untreated rosacea. METHODS: Of the total 24 subjects enrolled, 8 had papulopustular rosacea (PPR), 8 had erythematotelangiectatic rosacea (ETR) and 8 were control subjects. Subjective burning perception, heat pain threshold, skin blood flow, and skin temperature was assessed in all subjects. In the ETR and PPR groups, two areas were compared: affected and nonaffected. RESULTS: Heat pain thresholds of areas affected by rosacea were lower than those of nonaffected areas. In addition, subjective burning perception was increased in rosacea patients when compared with control subjects. Although PPR-affected skin had elevated skin blood flow when compared with nonaffected skin, this was not significant for ETR-affected skin. LIMITATIONS: The small number of subjects enrolled was the main limitation. CONCLUSION: This study showed enhanced sensitivity to noxious heat stimuli in rosacea-affected skin, which was more prominent in the PPR group. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/17658664/Enhanced_skin_blood_flow_and_sensitivity_to_noxious_heat_stimuli_in_papulopustular_rosacea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(07)01027-4 DB - PRIME DP - Unbound Medicine ER -