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Narrow-band UVB phototherapy combined with tacrolimus ointment in vitiligo: a review of 110 patients.
J Eur Acad Dermatol Venereol. 2007 Aug; 21(7):916-20.JE

Abstract

BACKGROUND

Narrow-band ultraviolet B (NB-UVB) phototherapy and topical tacrolimus are included among the most innovative approaches to vitiligo.

OBJECTIVE

To evaluate the efficacy and tolerability of combined treatment with NB-UVB and topical tacrolimus in vitiligo.

METHODS

After informed consent, adult patients with chronic (> 1-year duration) stable vitiligo refractory to conventional treatments were enrolled in an open-labelled prospective study. Treatment regimen consists of once-daily application, in the evening, of tacrolimus 0.03% ointment to the lesions of the face, or tacrolimus 0.1% ointment to the vitiligous patches located on other areas. Concomitant NB-UVB phototherapy was performed twice weekly for 16 weeks.

RESULTS

Study population included 110 patients (mean age, 42) with a total of 403 lesions. Within the treatment period, variable repigmentation was evident on more than 70% of lesions. Clinical response (repigmentation more than 50%) was observed in 42% of lesions. Response was strictly dependent on the site, being more frequent for face lesions (73%), followed by limbs (68%) and trunk (53.5%). The therapeutic effect on the extremities and genital areas was quite disappointing. Treatment was well tolerated.

CONCLUSIONS

Our preliminary data suggest that the combination of topical tacrolimus with NB-UVB phototherapy can represent an alternative highly effective approach to refractory vitiligo located on the face, trunk and limbs. Long-term safety data and randomized controlled trials on a large number of patients are required.

Authors+Show Affiliations

Phototherapy Unit, Dermatology Service, AUSL LE2, Gagliano del Capo-Maglie, Via Umberto I 16, 73052 Parabita (LE), Salento, Italy. hello@dariofai.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17659000

Citation

Fai, D, et al. "Narrow-band UVB Phototherapy Combined With Tacrolimus Ointment in Vitiligo: a Review of 110 Patients." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 21, no. 7, 2007, pp. 916-20.
Fai D, Cassano N, Vena GA. Narrow-band UVB phototherapy combined with tacrolimus ointment in vitiligo: a review of 110 patients. J Eur Acad Dermatol Venereol. 2007;21(7):916-20.
Fai, D., Cassano, N., & Vena, G. A. (2007). Narrow-band UVB phototherapy combined with tacrolimus ointment in vitiligo: a review of 110 patients. Journal of the European Academy of Dermatology and Venereology : JEADV, 21(7), 916-20.
Fai D, Cassano N, Vena GA. Narrow-band UVB Phototherapy Combined With Tacrolimus Ointment in Vitiligo: a Review of 110 Patients. J Eur Acad Dermatol Venereol. 2007;21(7):916-20. PubMed PMID: 17659000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Narrow-band UVB phototherapy combined with tacrolimus ointment in vitiligo: a review of 110 patients. AU - Fai,D, AU - Cassano,N, AU - Vena,G A, PY - 2007/7/31/pubmed PY - 2007/11/9/medline PY - 2007/7/31/entrez SP - 916 EP - 20 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 21 IS - 7 N2 - BACKGROUND: Narrow-band ultraviolet B (NB-UVB) phototherapy and topical tacrolimus are included among the most innovative approaches to vitiligo. OBJECTIVE: To evaluate the efficacy and tolerability of combined treatment with NB-UVB and topical tacrolimus in vitiligo. METHODS: After informed consent, adult patients with chronic (> 1-year duration) stable vitiligo refractory to conventional treatments were enrolled in an open-labelled prospective study. Treatment regimen consists of once-daily application, in the evening, of tacrolimus 0.03% ointment to the lesions of the face, or tacrolimus 0.1% ointment to the vitiligous patches located on other areas. Concomitant NB-UVB phototherapy was performed twice weekly for 16 weeks. RESULTS: Study population included 110 patients (mean age, 42) with a total of 403 lesions. Within the treatment period, variable repigmentation was evident on more than 70% of lesions. Clinical response (repigmentation more than 50%) was observed in 42% of lesions. Response was strictly dependent on the site, being more frequent for face lesions (73%), followed by limbs (68%) and trunk (53.5%). The therapeutic effect on the extremities and genital areas was quite disappointing. Treatment was well tolerated. CONCLUSIONS: Our preliminary data suggest that the combination of topical tacrolimus with NB-UVB phototherapy can represent an alternative highly effective approach to refractory vitiligo located on the face, trunk and limbs. Long-term safety data and randomized controlled trials on a large number of patients are required. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/17659000/Narrow_band_UVB_phototherapy_combined_with_tacrolimus_ointment_in_vitiligo:_a_review_of_110_patients_ L2 - https://doi.org/10.1111/j.1468-3083.2006.02101.x DB - PRIME DP - Unbound Medicine ER -