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Comparison between 308-nm monochromatic excimer light and narrowband UVB phototherapy (311-313 nm) in the treatment of vitiligo--a multicentre controlled study.
J Eur Acad Dermatol Venereol. 2007 Aug; 21(7):956-63.JE

Abstract

BACKGROUND

Vitiligo is an acquired pigmentary disorder characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. Recently, it has been shown that narrowband ultraviolet B (NB-UVB) phototherapy may be more effective than psoralen and ultraviolet A (PUVA) photochemotherapy in treating vitiligo, and that 308-nm monochromatic excimer light (MEL) may present some advantages as compared to NB-UVB for the treatment of vitiligo. AIM The aim of this study was to compare the effectiveness of NB-UVB phototherapy and 308-nm MEL in vitiligo patients.

METHODS

The study was done in a randomized, investigator-blinded and half-side comparison design. Twenty-one subjects with symmetrical vitiligo lesions were enrolled in this study. Vitiligo lesions on one body side were treated twice weekly for 6 months with 308-nm MEL, while NB-UVB phototherapy was used to treat lesions on the opposite side.

RESULTS

At the end of the study six lesions (37.5%) treated with 308-nm MEL and only one lesion (6%) treated with NB-UVB achieved an excellent repigmentation (score 4) while four lesions (25%) treated with 308-nm MEL and five lesions (31%) treated with NB-UVB showed a good repigmentation (score 3).

CONCLUSIONS

It appears that 308-nm MEL is more effective than NB-UVB in treating vitiligo lesions and it induces repigmentation more rapidly.

Authors+Show Affiliations

Dermatology Clinic, Huriez Hospital, University of Lille 2, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

17659006

Citation

Casacci, M, et al. "Comparison Between 308-nm Monochromatic Excimer Light and Narrowband UVB Phototherapy (311-313 Nm) in the Treatment of Vitiligo--a Multicentre Controlled Study." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 21, no. 7, 2007, pp. 956-63.
Casacci M, Thomas P, Pacifico A, et al. Comparison between 308-nm monochromatic excimer light and narrowband UVB phototherapy (311-313 nm) in the treatment of vitiligo--a multicentre controlled study. J Eur Acad Dermatol Venereol. 2007;21(7):956-63.
Casacci, M., Thomas, P., Pacifico, A., Bonnevalle, A., Paro Vidolin, A., & Leone, G. (2007). Comparison between 308-nm monochromatic excimer light and narrowband UVB phototherapy (311-313 nm) in the treatment of vitiligo--a multicentre controlled study. Journal of the European Academy of Dermatology and Venereology : JEADV, 21(7), 956-63.
Casacci M, et al. Comparison Between 308-nm Monochromatic Excimer Light and Narrowband UVB Phototherapy (311-313 Nm) in the Treatment of Vitiligo--a Multicentre Controlled Study. J Eur Acad Dermatol Venereol. 2007;21(7):956-63. PubMed PMID: 17659006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison between 308-nm monochromatic excimer light and narrowband UVB phototherapy (311-313 nm) in the treatment of vitiligo--a multicentre controlled study. AU - Casacci,M, AU - Thomas,P, AU - Pacifico,A, AU - Bonnevalle,A, AU - Paro Vidolin,A, AU - Leone,G, PY - 2007/7/31/pubmed PY - 2007/11/9/medline PY - 2007/7/31/entrez SP - 956 EP - 63 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 21 IS - 7 N2 - BACKGROUND: Vitiligo is an acquired pigmentary disorder characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. Recently, it has been shown that narrowband ultraviolet B (NB-UVB) phototherapy may be more effective than psoralen and ultraviolet A (PUVA) photochemotherapy in treating vitiligo, and that 308-nm monochromatic excimer light (MEL) may present some advantages as compared to NB-UVB for the treatment of vitiligo. AIM The aim of this study was to compare the effectiveness of NB-UVB phototherapy and 308-nm MEL in vitiligo patients. METHODS: The study was done in a randomized, investigator-blinded and half-side comparison design. Twenty-one subjects with symmetrical vitiligo lesions were enrolled in this study. Vitiligo lesions on one body side were treated twice weekly for 6 months with 308-nm MEL, while NB-UVB phototherapy was used to treat lesions on the opposite side. RESULTS: At the end of the study six lesions (37.5%) treated with 308-nm MEL and only one lesion (6%) treated with NB-UVB achieved an excellent repigmentation (score 4) while four lesions (25%) treated with 308-nm MEL and five lesions (31%) treated with NB-UVB showed a good repigmentation (score 3). CONCLUSIONS: It appears that 308-nm MEL is more effective than NB-UVB in treating vitiligo lesions and it induces repigmentation more rapidly. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/17659006/Comparison_between_308_nm_monochromatic_excimer_light_and_narrowband_UVB_phototherapy__311_313_nm__in_the_treatment_of_vitiligo__a_multicentre_controlled_study_ L2 - https://doi.org/10.1111/j.1468-3083.2007.02151.x DB - PRIME DP - Unbound Medicine ER -