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Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 01; 31(7):1393-6.PN

Abstract

Dietary deficiencies in essential omega-3 polyunsaturated fatty acids derived from fish are associated with depression and some fish oils may have therapeutic benefits. We aimed to determine whether taking tuna fish oil confers any additional benefit to conventional outpatient treatment for major depression. A randomized double-blind placebo-controlled four-month trial comparing tuna fish oil versus placebo was conducted on 83 outpatients with major depression. Despite large reductions in depression there were no significant differences at any assessment time point between patients receiving fish oil compared to placebo. Red blood cell incorporation of fatty acids indicated good compliance with oil supplementation, although this sample was not initially deficient in omega-3s. This particular dose and type of fish oil conferred no additional benefit to conventional treatment of depression in this sample. Future studies could target participants with pre-existing omega-3 deficiency and appraise alternate enriched types and higher doses of omega-3 supplementation.

Authors+Show Affiliations

Illawarra Institute for Mental Health and Smart Foods Centre, University of Wollongong NSW 2522, Australia. grenyer@uow.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17659823

Citation

Grenyer, Brin F S., et al. "Fish Oil Supplementation in the Treatment of Major Depression: a Randomised Double-blind Placebo-controlled Trial." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 31, no. 7, 2007, pp. 1393-6.
Grenyer BF, Crowe T, Meyer B, et al. Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(7):1393-6.
Grenyer, B. F., Crowe, T., Meyer, B., Owen, A. J., Grigonis-Deane, E. M., Caputi, P., & Howe, P. R. (2007). Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial. Progress in Neuro-psychopharmacology & Biological Psychiatry, 31(7), 1393-6.
Grenyer BF, et al. Fish Oil Supplementation in the Treatment of Major Depression: a Randomised Double-blind Placebo-controlled Trial. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 1;31(7):1393-6. PubMed PMID: 17659823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial. AU - Grenyer,Brin F S, AU - Crowe,Trevor, AU - Meyer,Barbara, AU - Owen,Alice J, AU - Grigonis-Deane,Elizabeth M, AU - Caputi,Peter, AU - Howe,Peter R C, Y1 - 2007/06/19/ PY - 2006/09/04/received PY - 2007/04/25/revised PY - 2007/06/12/accepted PY - 2007/7/31/pubmed PY - 2007/12/7/medline PY - 2007/7/31/entrez SP - 1393 EP - 6 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 31 IS - 7 N2 - Dietary deficiencies in essential omega-3 polyunsaturated fatty acids derived from fish are associated with depression and some fish oils may have therapeutic benefits. We aimed to determine whether taking tuna fish oil confers any additional benefit to conventional outpatient treatment for major depression. A randomized double-blind placebo-controlled four-month trial comparing tuna fish oil versus placebo was conducted on 83 outpatients with major depression. Despite large reductions in depression there were no significant differences at any assessment time point between patients receiving fish oil compared to placebo. Red blood cell incorporation of fatty acids indicated good compliance with oil supplementation, although this sample was not initially deficient in omega-3s. This particular dose and type of fish oil conferred no additional benefit to conventional treatment of depression in this sample. Future studies could target participants with pre-existing omega-3 deficiency and appraise alternate enriched types and higher doses of omega-3 supplementation. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17659823/Fish_oil_supplementation_in_the_treatment_of_major_depression:_a_randomised_double_blind_placebo_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00196-0 DB - PRIME DP - Unbound Medicine ER -