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[Causes and treatment of hypomagnesemia].
Clin Calcium 2007; 17(8):1241-8CC

Abstract

Plasma magnesium (Mg) is known to be maintained within a normal range through its gastrointestinal absorption as well as renal excretion, and disturbances at these sites might cause hypomagnesemia. Mg balance is most susceptible to the malfunction of the thick ascending limb of renal tubules, because 70% of urinary Mg excretion is reabsorbed from this site. Investigation of hypomagnesemia-exhibiting inherited diseases revealed molecular mechanisms of Mg transport pathways; paracellin-1 as a passive paracellular transport and TRPM6 as an active transcellular transport. Mild and severe hypomagnesemia are treated with oral replacement such as magnesium oxide, as well as intravenous administration of magnesium sulfate.

Authors+Show Affiliations

Shimane University Faculty of Medicine, Department of Internal Medicine 1, Japan.No affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article
Review

Language

jpn

PubMed ID

17660622

Citation

Yamamoto, Masahiro, and Toru Yamaguchi. "[Causes and Treatment of Hypomagnesemia]." Clinical Calcium, vol. 17, no. 8, 2007, pp. 1241-8.
Yamamoto M, Yamaguchi T. [Causes and treatment of hypomagnesemia]. Clin Calcium. 2007;17(8):1241-8.
Yamamoto, M., & Yamaguchi, T. (2007). [Causes and treatment of hypomagnesemia]. Clinical Calcium, 17(8), pp. 1241-8.
Yamamoto M, Yamaguchi T. [Causes and Treatment of Hypomagnesemia]. Clin Calcium. 2007;17(8):1241-8. PubMed PMID: 17660622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Causes and treatment of hypomagnesemia]. AU - Yamamoto,Masahiro, AU - Yamaguchi,Toru, PY - 2007/7/31/pubmed PY - 2007/10/3/medline PY - 2007/7/31/entrez SP - 1241 EP - 8 JF - Clinical calcium JO - Clin Calcium VL - 17 IS - 8 N2 - Plasma magnesium (Mg) is known to be maintained within a normal range through its gastrointestinal absorption as well as renal excretion, and disturbances at these sites might cause hypomagnesemia. Mg balance is most susceptible to the malfunction of the thick ascending limb of renal tubules, because 70% of urinary Mg excretion is reabsorbed from this site. Investigation of hypomagnesemia-exhibiting inherited diseases revealed molecular mechanisms of Mg transport pathways; paracellin-1 as a passive paracellular transport and TRPM6 as an active transcellular transport. Mild and severe hypomagnesemia are treated with oral replacement such as magnesium oxide, as well as intravenous administration of magnesium sulfate. SN - 0917-5857 UR - https://www.unboundmedicine.com/medline/citation/17660622/[Causes_and_treatment_of_hypomagnesemia]_ DB - PRIME DP - Unbound Medicine ER -