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An updated review of inhalation studies with cigarette smoke in laboratory animals.
Int J Toxicol. 2007 Jul-Aug; 26(4):331-8.IJ

Abstract

Until recently, the published literature on inhalation studies with laboratory animals and cigarette smoke consisted entirely of negative findings, as far as neoplastic disease is concerned. This paper brings readers up to date, with analyses of recent studies that do indeed appear to report success after so many years of failure. The paper consists of a brief analysis of the literature up until a couple of years ago, giving brief, representative examples of inhalation studies with the five main species of laboratory animals that have been used: rat, mouse, hamster, dog, and nonhuman primate. A brief examination of the various technologies used to expose laboratory animals is given, along with an analysis of the histopathology and related toxicology data (specifically, biomarkers of exposure) that have been reported. The paper concludes by briefly mentioning the most recent studies, where positive results have been reported.

Authors+Show Affiliations

Carson Watts Consulting, 1266 CarsonWatts Road, King, North Carolina 27021-7453, USA. chris@carsonwattsconsulting.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17661224

Citation

Coggins, Christopher R E.. "An Updated Review of Inhalation Studies With Cigarette Smoke in Laboratory Animals." International Journal of Toxicology, vol. 26, no. 4, 2007, pp. 331-8.
Coggins CR. An updated review of inhalation studies with cigarette smoke in laboratory animals. Int J Toxicol. 2007;26(4):331-8.
Coggins, C. R. (2007). An updated review of inhalation studies with cigarette smoke in laboratory animals. International Journal of Toxicology, 26(4), 331-8.
Coggins CR. An Updated Review of Inhalation Studies With Cigarette Smoke in Laboratory Animals. Int J Toxicol. 2007 Jul-Aug;26(4):331-8. PubMed PMID: 17661224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An updated review of inhalation studies with cigarette smoke in laboratory animals. A1 - Coggins,Christopher R E, PY - 2007/7/31/pubmed PY - 2007/10/12/medline PY - 2007/7/31/entrez SP - 331 EP - 8 JF - International journal of toxicology JO - Int J Toxicol VL - 26 IS - 4 N2 - Until recently, the published literature on inhalation studies with laboratory animals and cigarette smoke consisted entirely of negative findings, as far as neoplastic disease is concerned. This paper brings readers up to date, with analyses of recent studies that do indeed appear to report success after so many years of failure. The paper consists of a brief analysis of the literature up until a couple of years ago, giving brief, representative examples of inhalation studies with the five main species of laboratory animals that have been used: rat, mouse, hamster, dog, and nonhuman primate. A brief examination of the various technologies used to expose laboratory animals is given, along with an analysis of the histopathology and related toxicology data (specifically, biomarkers of exposure) that have been reported. The paper concludes by briefly mentioning the most recent studies, where positive results have been reported. SN - 1091-5818 UR - https://www.unboundmedicine.com/medline/citation/17661224/An_updated_review_of_inhalation_studies_with_cigarette_smoke_in_laboratory_animals_ L2 - https://journals.sagepub.com/doi/10.1080/10915810701490190?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -