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Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study.
J Am Geriatr Soc. 2007 Aug; 55(8):1161-7.JA

Abstract

OBJECTIVES

To assess variation in the association between blood pressure (BP) and risk for dementia across a spectrum of older ages and to examine BP changes before dementia onset.

DESIGN

Prospective cohort study.

SETTING

A large health maintenance organization in Seattle, Washington.

PARTICIPANTS

A cohort of 2,356 members of a large health maintenance organization aged 65 and older who were initially without dementia.

MEASUREMENTS

Dementia diagnosis was assessed biennially, and systolic (SBP) and diastolic BP (DBP) were measured at baseline and at four follow-up assessments. Cox proportional hazards models were used to estimate hazard ratios (HRs) for dementia and Alzheimer's disease (AD) associated with baseline BP in different age groups.

RESULTS

Within the youngest age group (65-74 at enrollment) a greater risk for dementia was found in participants with high SBP (> or = 160 mmHg) (hazard ratio (HR) = 1.60, 95% confidence interval (CI) = 1.01-2.55) or borderline-high DBP (80-89 mmHg) (HR = 1.59, 95% CI = 1.07-2.35) than for those with normal BP (SBP < 140 mmHg and DBP < 80 mmHg). The dementia risk associated with SBP declined with increasing age (SBP-by-age interaction, P=.01). SBP declined similarly with aging in subjects who developed dementia and those who did not. Thus, in this sample, the association between SBP and dementia risk was not dependent on when BP was measured in relation to onset of dementia.

CONCLUSION

High SBP was associated with greater risk of dementia in the young elderly (< 75) but not in older subjects. Adequate control of hypertension in early old age may reduce the risk for dementia.

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Authors+Show Affiliations

Li G
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA. gli@u.washington.edu
Rhew IC
No affiliation info available
Shofer JB
No affiliation info available
Kukull WA
No affiliation info available
Breitner JC
No affiliation info available
Peskind E
No affiliation info available
Bowen JD
No affiliation info available
McCormick W
No affiliation info available
Teri L
No affiliation info available
Crane PK
No affiliation info available
Larson EB
No affiliation info available

MeSH

Age FactorsAgedAged, 80 and overBlood PressureDementiaFemaleHumansHypertensionMaleProspective StudiesRisk Factors

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17661953

Citation

Li, Ge, et al. "Age-varying Association Between Blood Pressure and Risk of Dementia in Those Aged 65 and Older: a Community-based Prospective Cohort Study." Journal of the American Geriatrics Society, vol. 55, no. 8, 2007, pp. 1161-7.
Li G, Rhew IC, Shofer JB, et al. Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study. J Am Geriatr Soc. 2007;55(8):1161-7.
Li, G., Rhew, I. C., Shofer, J. B., Kukull, W. A., Breitner, J. C., Peskind, E., Bowen, J. D., McCormick, W., Teri, L., Crane, P. K., & Larson, E. B. (2007). Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study. Journal of the American Geriatrics Society, 55(8), 1161-7.
Li G, et al. Age-varying Association Between Blood Pressure and Risk of Dementia in Those Aged 65 and Older: a Community-based Prospective Cohort Study. J Am Geriatr Soc. 2007;55(8):1161-7. PubMed PMID: 17661953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study. AU - Li,Ge, AU - Rhew,Isaac C, AU - Shofer,Jane B, AU - Kukull,Walter A, AU - Breitner,John C S, AU - Peskind,Elaine, AU - Bowen,James D, AU - McCormick,Wayne, AU - Teri,Linda, AU - Crane,Paul K, AU - Larson,Eric B, PY - 2007/7/31/pubmed PY - 2007/10/3/medline PY - 2007/7/31/entrez SP - 1161 EP - 7 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 55 IS - 8 N2 - OBJECTIVES: To assess variation in the association between blood pressure (BP) and risk for dementia across a spectrum of older ages and to examine BP changes before dementia onset. DESIGN: Prospective cohort study. SETTING: A large health maintenance organization in Seattle, Washington. PARTICIPANTS: A cohort of 2,356 members of a large health maintenance organization aged 65 and older who were initially without dementia. MEASUREMENTS: Dementia diagnosis was assessed biennially, and systolic (SBP) and diastolic BP (DBP) were measured at baseline and at four follow-up assessments. Cox proportional hazards models were used to estimate hazard ratios (HRs) for dementia and Alzheimer's disease (AD) associated with baseline BP in different age groups. RESULTS: Within the youngest age group (65-74 at enrollment) a greater risk for dementia was found in participants with high SBP (> or = 160 mmHg) (hazard ratio (HR) = 1.60, 95% confidence interval (CI) = 1.01-2.55) or borderline-high DBP (80-89 mmHg) (HR = 1.59, 95% CI = 1.07-2.35) than for those with normal BP (SBP < 140 mmHg and DBP < 80 mmHg). The dementia risk associated with SBP declined with increasing age (SBP-by-age interaction, P=.01). SBP declined similarly with aging in subjects who developed dementia and those who did not. Thus, in this sample, the association between SBP and dementia risk was not dependent on when BP was measured in relation to onset of dementia. CONCLUSION: High SBP was associated with greater risk of dementia in the young elderly (< 75) but not in older subjects. Adequate control of hypertension in early old age may reduce the risk for dementia. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/17661953/Age_varying_association_between_blood_pressure_and_risk_of_dementia_in_those_aged_65_and_older:_a_community_based_prospective_cohort_study_ L2 - https://doi.org/10.1111/j.1532-5415.2007.01233.x DB - PRIME DP - Unbound Medicine ER -