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Fourth-generation fluoroquinolone-resistant bacterial keratitis.
J Cataract Refract Surg. 2007 Aug; 33(8):1488-9.JC

Abstract

Corneal scrapings were collected from a case of keratitis and microbiological investigations done. Coagulase-negative Staphylococcus (Staphylococcus epidermidis) was identified on culture, and antibiotic susceptibility tests were performed. Treatment was started with topical cefazolin sulfate 5% and gatifloxacin 0.3%; this was subsequently changed to vancomycin 5% and tobramycin sulfate 1.3% based on the sensitivity pattern. The isolates of this bacterium were susceptible to vancomycin, tobramycin, and gentamicin, and resistance was present against moxifloxacin, gatifloxacin, ciprofloxacin, and cefazolin. The case highlights the occurrence of keratitis caused by coagulase-negative Staphylococcus that is resistant to treatment with moxifloxacin.

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Authors+Show Affiliations

Jhanji V
Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Sharma N
No affiliation info available
Satpathy G
No affiliation info available
Titiyal J
No affiliation info available

MeSH

AdultAnti-Bacterial AgentsAza CompoundsCorneal UlcerDrug Resistance, BacterialDrug Therapy, CombinationEye Infections, BacterialFluoroquinolonesHumansMaleMicrobial Sensitivity TestsMoxifloxacinQuinolinesStaphylococcal InfectionsStaphylococcus epidermidisTobramycinVancomycin

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17662450

Citation

Jhanji, Vishal, et al. "Fourth-generation Fluoroquinolone-resistant Bacterial Keratitis." Journal of Cataract and Refractive Surgery, vol. 33, no. 8, 2007, pp. 1488-9.
Jhanji V, Sharma N, Satpathy G, et al. Fourth-generation fluoroquinolone-resistant bacterial keratitis. J Cataract Refract Surg. 2007;33(8):1488-9.
Jhanji, V., Sharma, N., Satpathy, G., & Titiyal, J. (2007). Fourth-generation fluoroquinolone-resistant bacterial keratitis. Journal of Cataract and Refractive Surgery, 33(8), 1488-9.
Jhanji V, et al. Fourth-generation Fluoroquinolone-resistant Bacterial Keratitis. J Cataract Refract Surg. 2007;33(8):1488-9. PubMed PMID: 17662450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fourth-generation fluoroquinolone-resistant bacterial keratitis. AU - Jhanji,Vishal, AU - Sharma,Namrata, AU - Satpathy,Gita, AU - Titiyal,Jeewan, PY - 2007/02/28/received PY - 2007/04/05/accepted PY - 2007/7/31/pubmed PY - 2007/10/2/medline PY - 2007/7/31/entrez SP - 1488 EP - 9 JF - Journal of cataract and refractive surgery JO - J Cataract Refract Surg VL - 33 IS - 8 N2 - Corneal scrapings were collected from a case of keratitis and microbiological investigations done. Coagulase-negative Staphylococcus (Staphylococcus epidermidis) was identified on culture, and antibiotic susceptibility tests were performed. Treatment was started with topical cefazolin sulfate 5% and gatifloxacin 0.3%; this was subsequently changed to vancomycin 5% and tobramycin sulfate 1.3% based on the sensitivity pattern. The isolates of this bacterium were susceptible to vancomycin, tobramycin, and gentamicin, and resistance was present against moxifloxacin, gatifloxacin, ciprofloxacin, and cefazolin. The case highlights the occurrence of keratitis caused by coagulase-negative Staphylococcus that is resistant to treatment with moxifloxacin. SN - 0886-3350 UR - https://www.unboundmedicine.com/medline/citation/17662450/Fourth_generation_fluoroquinolone_resistant_bacterial_keratitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0886-3350(07)00732-8 DB - PRIME DP - Unbound Medicine ER -