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[Visualization of microgilia in living tissues using Iba1-EGFP transgenic mice].
Brain Nerve 2007; 59(7):763-72BN

Abstract

Microglia are thought to play pathologic and regenerative states of the brain. We generated transgenic mice with expression of EGFP under the control of the Iba1 promoter, a specific protein of macrophages/microglia. In this mice, we observed the EGFP-positive cells in living tissues and brain, and we could visualize the EGFP-expressing microglia in living brain sections from embryonic stage to adult stage. This method is useful tool to study the microglial dynamic movement in vivo, and provide the new finding of role of microglia.

Authors+Show Affiliations

Department of Epigenetic Medicine, Faculty of Medicine Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

17663148

Citation

Hirasawa, Takae, and Shinichi Kohsaka. "[Visualization of Microgilia in Living Tissues Using Iba1-EGFP Transgenic Mice]." Brain and Nerve = Shinkei Kenkyu No Shinpo, vol. 59, no. 7, 2007, pp. 763-72.
Hirasawa T, Kohsaka S. [Visualization of microgilia in living tissues using Iba1-EGFP transgenic mice]. Brain Nerve. 2007;59(7):763-72.
Hirasawa, T., & Kohsaka, S. (2007). [Visualization of microgilia in living tissues using Iba1-EGFP transgenic mice]. Brain and Nerve = Shinkei Kenkyu No Shinpo, 59(7), pp. 763-72.
Hirasawa T, Kohsaka S. [Visualization of Microgilia in Living Tissues Using Iba1-EGFP Transgenic Mice]. Brain Nerve. 2007;59(7):763-72. PubMed PMID: 17663148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Visualization of microgilia in living tissues using Iba1-EGFP transgenic mice]. AU - Hirasawa,Takae, AU - Kohsaka,Shinichi, PY - 2007/8/1/pubmed PY - 2007/9/15/medline PY - 2007/8/1/entrez SP - 763 EP - 72 JF - Brain and nerve = Shinkei kenkyu no shinpo JO - Brain Nerve VL - 59 IS - 7 N2 - Microglia are thought to play pathologic and regenerative states of the brain. We generated transgenic mice with expression of EGFP under the control of the Iba1 promoter, a specific protein of macrophages/microglia. In this mice, we observed the EGFP-positive cells in living tissues and brain, and we could visualize the EGFP-expressing microglia in living brain sections from embryonic stage to adult stage. This method is useful tool to study the microglial dynamic movement in vivo, and provide the new finding of role of microglia. SN - 1881-6096 UR - https://www.unboundmedicine.com/medline/citation/17663148/[Visualization_of_microgilia_in_living_tissues_using_Iba1_EGFP_transgenic_mice]_ L2 - https://webview.isho.jp/openurl?rft.genre=article&rft.issn=1881-6096&rft.volume=59&rft.issue=7&rft.spage=763 DB - PRIME DP - Unbound Medicine ER -