Tags

Type your tag names separated by a space and hit enter

The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories.
Behav Neurosci. 2007 Aug; 121(4):721-31.BN

Abstract

The authors used 3-phase context preexposure facilitation methodology to study the contribution of N-methyl-D-aspartate (NMDA) receptors in dorsal hippocampus (DH) and the basal lateral region of the amygdala (BLA) to (a) acquisition of the context memory, (b) retrieval of the context memory, (c) acquisition of context-shock association, and (d) retrieval of the context-shock association. The NMDA receptor antagonist D-2-amino-5 phosphonopentanoic acid (D-AP5) was injected into either the DH or BLA prior to (a) the context preexposure phase, (b) the immediate shock phase, or (c) the test for contextual fear. Antagonizing NMDA receptors in the DH impaired the acquisition of the context memory but did not affect its retrieval or retrieval of the fear memory. Antagonizing NMDA receptors with D-AP5 in the BLA impaired acquisition of the context-shock association but had no effect on the expression of fear. However, both DL-AP5 and L-AP5 reduced the expression of fear when they were injected into the amygdala prior to testing for contextual fear.

Authors+Show Affiliations

Department of Psychology, University of Colorado, Boulder, CO 80309, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17663597

Citation

Matus-Amat, Patricia, et al. "The Role of Dorsal Hippocampus and Basolateral Amygdala NMDA Receptors in the Acquisition and Retrieval of Context and Contextual Fear Memories." Behavioral Neuroscience, vol. 121, no. 4, 2007, pp. 721-31.
Matus-Amat P, Higgins EA, Sprunger D, et al. The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories. Behav Neurosci. 2007;121(4):721-31.
Matus-Amat, P., Higgins, E. A., Sprunger, D., Wright-Hardesty, K., & Rudy, J. W. (2007). The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories. Behavioral Neuroscience, 121(4), 721-31.
Matus-Amat P, et al. The Role of Dorsal Hippocampus and Basolateral Amygdala NMDA Receptors in the Acquisition and Retrieval of Context and Contextual Fear Memories. Behav Neurosci. 2007;121(4):721-31. PubMed PMID: 17663597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories. AU - Matus-Amat,Patricia, AU - Higgins,Emily A, AU - Sprunger,David, AU - Wright-Hardesty,Karli, AU - Rudy,Jerry W, PY - 2007/8/1/pubmed PY - 2007/10/13/medline PY - 2007/8/1/entrez SP - 721 EP - 31 JF - Behavioral neuroscience JO - Behav Neurosci VL - 121 IS - 4 N2 - The authors used 3-phase context preexposure facilitation methodology to study the contribution of N-methyl-D-aspartate (NMDA) receptors in dorsal hippocampus (DH) and the basal lateral region of the amygdala (BLA) to (a) acquisition of the context memory, (b) retrieval of the context memory, (c) acquisition of context-shock association, and (d) retrieval of the context-shock association. The NMDA receptor antagonist D-2-amino-5 phosphonopentanoic acid (D-AP5) was injected into either the DH or BLA prior to (a) the context preexposure phase, (b) the immediate shock phase, or (c) the test for contextual fear. Antagonizing NMDA receptors in the DH impaired the acquisition of the context memory but did not affect its retrieval or retrieval of the fear memory. Antagonizing NMDA receptors with D-AP5 in the BLA impaired acquisition of the context-shock association but had no effect on the expression of fear. However, both DL-AP5 and L-AP5 reduced the expression of fear when they were injected into the amygdala prior to testing for contextual fear. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/17663597/The_role_of_dorsal_hippocampus_and_basolateral_amygdala_NMDA_receptors_in_the_acquisition_and_retrieval_of_context_and_contextual_fear_memories_ L2 - http://content.apa.org/journals/bne/121/4/721 DB - PRIME DP - Unbound Medicine ER -