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Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants.

Abstract

The effect of diet v. statins on LDL particle size as a risk factor for CVD has not been examined. We compared, in the same subjects, the impact of a dietary portfolio of cholesterol-lowering foods and a statin on LDL size electrophoretic characteristics. Thirty-four hyperlipidaemic subjects completed three 1-month treatments as outpatients in random order: a very-low saturated fat diet (control); the same diet with 20 mg lovastatin; a dietary portfolio high in plant sterols (1 g/4200 kJ), soya proteins (21.4 g/4200 kJ), soluble fibres (9.8 g/4200 kJ) and almonds (14 g/4200 kJ). LDL electrophoretic characteristics were measured by non-denaturing polyacrylamide gradient gel electrophoresis of fasting plasma at 0, 2 and 4 weeks of each treatment. The reductions in plasma LDL-cholesterol levels with the dietary portfolio and with statins were comparable and were largely attributable to reductions in the estimated concentration of cholesterol within the smallest subclass of LDL (portfolio - 0.69 (se 0.10) mmol/l, statin - 0.99 (se 0.10) mmol/l). These were significantly greater (P < 0.01) than changes observed after the control diet ( - 0.17 (se 0.08) mmol/l). Finally, baseline C-reactive protein levels were a significant predictor of the LDL size responsiveness to the dietary portfolio but not to the other treatments. The dietary portfolio, like the statin treatment, had only minor effects on several features of the LDL size phenotype, but the pronounced reduction in cholesterol levels within the small LDL fraction may provide additional cardiovascular benefit over the traditional low-fat diet of National Cholesterol Education Program Step II.

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  • Authors+Show Affiliations

    ,

    Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, Canada.

    , , , , , , , , , , ,

    Source

    The British journal of nutrition 98:6 2007 Dec pg 1229-36

    MeSH

    Aged
    Analysis of Variance
    C-Reactive Protein
    Cardiovascular Diseases
    Cholesterol, LDL
    Cross-Over Studies
    Diet, Fat-Restricted
    Dietary Fats
    Dietary Fiber
    Female
    Humans
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Hypercholesterolemia
    Lipids
    Lovastatin
    Male
    Middle Aged
    Particle Size
    Phytosterols
    Risk

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17663803

    Citation

    Gigleux, Iris, et al. "Comparison of a Dietary Portfolio Diet of Cholesterol-lowering Foods and a Statin On LDL Particle Size Phenotype in Hypercholesterolaemic Participants." The British Journal of Nutrition, vol. 98, no. 6, 2007, pp. 1229-36.
    Gigleux I, Jenkins DJ, Kendall CW, et al. Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants. Br J Nutr. 2007;98(6):1229-36.
    Gigleux, I., Jenkins, D. J., Kendall, C. W., Marchie, A., Faulkner, D. A., Wong, J. M., ... Lamarche, B. (2007). Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants. The British Journal of Nutrition, 98(6), pp. 1229-36.
    Gigleux I, et al. Comparison of a Dietary Portfolio Diet of Cholesterol-lowering Foods and a Statin On LDL Particle Size Phenotype in Hypercholesterolaemic Participants. Br J Nutr. 2007;98(6):1229-36. PubMed PMID: 17663803.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants. AU - Gigleux,Iris, AU - Jenkins,David J A, AU - Kendall,Cyril W C, AU - Marchie,Augustine, AU - Faulkner,Dorothea A, AU - Wong,Julia M W, AU - de Souza,Russell, AU - Emam,Azadeh, AU - Parker,Tina L, AU - Trautwein,Elke A, AU - Lapsley,Karen G, AU - Connelly,Philip W, AU - Lamarche,Benoît, Y1 - 2007/07/30/ PY - 2007/8/1/pubmed PY - 2008/3/14/medline PY - 2007/8/1/entrez SP - 1229 EP - 36 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 98 IS - 6 N2 - The effect of diet v. statins on LDL particle size as a risk factor for CVD has not been examined. We compared, in the same subjects, the impact of a dietary portfolio of cholesterol-lowering foods and a statin on LDL size electrophoretic characteristics. Thirty-four hyperlipidaemic subjects completed three 1-month treatments as outpatients in random order: a very-low saturated fat diet (control); the same diet with 20 mg lovastatin; a dietary portfolio high in plant sterols (1 g/4200 kJ), soya proteins (21.4 g/4200 kJ), soluble fibres (9.8 g/4200 kJ) and almonds (14 g/4200 kJ). LDL electrophoretic characteristics were measured by non-denaturing polyacrylamide gradient gel electrophoresis of fasting plasma at 0, 2 and 4 weeks of each treatment. The reductions in plasma LDL-cholesterol levels with the dietary portfolio and with statins were comparable and were largely attributable to reductions in the estimated concentration of cholesterol within the smallest subclass of LDL (portfolio - 0.69 (se 0.10) mmol/l, statin - 0.99 (se 0.10) mmol/l). These were significantly greater (P < 0.01) than changes observed after the control diet ( - 0.17 (se 0.08) mmol/l). Finally, baseline C-reactive protein levels were a significant predictor of the LDL size responsiveness to the dietary portfolio but not to the other treatments. The dietary portfolio, like the statin treatment, had only minor effects on several features of the LDL size phenotype, but the pronounced reduction in cholesterol levels within the small LDL fraction may provide additional cardiovascular benefit over the traditional low-fat diet of National Cholesterol Education Program Step II. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17663803/Comparison_of_a_dietary_portfolio_diet_of_cholesterol_lowering_foods_and_a_statin_on_LDL_particle_size_phenotype_in_hypercholesterolaemic_participants_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507781461/type/journal_article DB - PRIME DP - Unbound Medicine ER -