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High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre-eclamptic pregnancies.
Clin Endocrinol (Oxf). 2007 Dec; 67(6):891-6.CE

Abstract

OBJECTIVE

This study is the first to report high molecular weight (HMW) adiponectin in newborns from normal and pre-eclamptic pregnancies (PE). Adiponectin is adversely related to Metabolic Syndrome-linked diseases such as obesity, dyslipidaemia, insulin resistance and hypertension. It is abundant in human plasma where it circulates as several characteristic multimeric forms of which the HMW form is the most active. As children from PE-pregnancies have a greater susceptibility to hypertensive disorders later in life, we hypothesized that adiponectin measured in cord blood could be a putative risk marker.

DESIGN AND PATIENTS

Cross-sectional, hospital-based study of newborns from mothers with pre-eclampsia (30 cases and 62 controls). Venous cord blood samples were collected immediately after birth and were analysed for total adiponectin and HMW adiponectin.

MEASUREMENTS

Total adiponectin and HMW adiponectin were measured by commercially available enzyme-linked immunosorbent assay (ELISA) kits.

RESULTS

The PE newborns showed a significantly lower gestational age (GA), total adiponectin and HMW adiponectin levels than the controls. No differences in adiponectin levels were found between case and control groups when correcting for GA. In combined groups, log (total adipo) = 0.40 + 0.027*GA; r = 0.43, P < 0.001. Furthermore, the HMW form is the dominant form of adiponectin: HMW adipo = -5.06 + 0.81*total adipo; r = 0.90, P < 0.001.

CONCLUSIONS

Adiponectin in cord blood from PE pregnancies may not be a tentative risk marker for Metabolic Syndrome-linked diseases. HMW adiponectin is the dominant form of adiponectin in cord blood. Its role during pregnancy and postnatal life should be further explored.

Authors+Show Affiliations

Institute of Clinical Biochemistry, Faculty of Medicine, University of Oslo and Department of Medical Biochemistry, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway. nancy.odden@rikshospitalet.noNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17666092

Citation

Odden, Nancy, and Lars Mørkrid. "High Molecular Weight Adiponectin Dominates in Cord Blood of Newborns but Is Unaffected By Pre-eclamptic Pregnancies." Clinical Endocrinology, vol. 67, no. 6, 2007, pp. 891-6.
Odden N, Mørkrid L. High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre-eclamptic pregnancies. Clin Endocrinol (Oxf). 2007;67(6):891-6.
Odden, N., & Mørkrid, L. (2007). High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre-eclamptic pregnancies. Clinical Endocrinology, 67(6), 891-6.
Odden N, Mørkrid L. High Molecular Weight Adiponectin Dominates in Cord Blood of Newborns but Is Unaffected By Pre-eclamptic Pregnancies. Clin Endocrinol (Oxf). 2007;67(6):891-6. PubMed PMID: 17666092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre-eclamptic pregnancies. AU - Odden,Nancy, AU - Mørkrid,Lars, Y1 - 2007/07/30/ PY - 2007/8/2/pubmed PY - 2012/4/25/medline PY - 2007/8/2/entrez SP - 891 EP - 6 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 67 IS - 6 N2 - OBJECTIVE: This study is the first to report high molecular weight (HMW) adiponectin in newborns from normal and pre-eclamptic pregnancies (PE). Adiponectin is adversely related to Metabolic Syndrome-linked diseases such as obesity, dyslipidaemia, insulin resistance and hypertension. It is abundant in human plasma where it circulates as several characteristic multimeric forms of which the HMW form is the most active. As children from PE-pregnancies have a greater susceptibility to hypertensive disorders later in life, we hypothesized that adiponectin measured in cord blood could be a putative risk marker. DESIGN AND PATIENTS: Cross-sectional, hospital-based study of newborns from mothers with pre-eclampsia (30 cases and 62 controls). Venous cord blood samples were collected immediately after birth and were analysed for total adiponectin and HMW adiponectin. MEASUREMENTS: Total adiponectin and HMW adiponectin were measured by commercially available enzyme-linked immunosorbent assay (ELISA) kits. RESULTS: The PE newborns showed a significantly lower gestational age (GA), total adiponectin and HMW adiponectin levels than the controls. No differences in adiponectin levels were found between case and control groups when correcting for GA. In combined groups, log (total adipo) = 0.40 + 0.027*GA; r = 0.43, P < 0.001. Furthermore, the HMW form is the dominant form of adiponectin: HMW adipo = -5.06 + 0.81*total adipo; r = 0.90, P < 0.001. CONCLUSIONS: Adiponectin in cord blood from PE pregnancies may not be a tentative risk marker for Metabolic Syndrome-linked diseases. HMW adiponectin is the dominant form of adiponectin in cord blood. Its role during pregnancy and postnatal life should be further explored. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/17666092/High_molecular_weight_adiponectin_dominates_in_cord_blood_of_newborns_but_is_unaffected_by_pre_eclamptic_pregnancies_ L2 - https://doi.org/10.1111/j.1365-2265.2007.02981.x DB - PRIME DP - Unbound Medicine ER -