Tags

Type your tag names separated by a space and hit enter

Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation.
J Allergy Clin Immunol. 2007 Aug; 120(2):238-44; quiz 245-6.JA

Abstract

It was demonstrated 5 years ago that thymic stromal lymphopoietin (TSLP), a IL-7-like cytokine produced by epithelial cells, could strongly activate human myeloid dendritic cells to induce an inflammatory T(H)2 response characterized by high TNF-alpha and little IL-10 production, distinct from the regulatory T(H)2 responses characterized by low TNF-alpha and high IL-10 production. TSLP was found highly expressed by keratinocytes of skin lesions of atopic dermatitis and associated with dendritic cell activation in situ. This suggests for the first time that TSLP represents a master switch of allergic inflammation at the epithelial cell and dendritic cell interface. During the last several years, the evidence for the association of TSLP with human asthma was revealed. The direct link between TSLP expression with the pathogenesis of atopic dermatitis and asthma in vivo was demonstrated. In addition, OX40 ligand was found to be the TSLP-induced molecule on dendritic cells that triggers inflammatory T(H)2 differentiation in the absence of IL-12. TSLP was also demonstrated to direct the innate phase of allergic immune responses through activating mast cells. Therefore, TSLP and OX40 ligand may represent important targets for intervention of the initiation of allergic inflammatory responses.

Authors+Show Affiliations

Department of Immunology and Center for Cancer Immunology Research, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030-1903, USA. yjliu@mdanderson.org

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17666213

Citation

Liu, Yong-Jun. "Thymic Stromal Lymphopoietin and OX40 Ligand Pathway in the Initiation of Dendritic Cell-mediated Allergic Inflammation." The Journal of Allergy and Clinical Immunology, vol. 120, no. 2, 2007, pp. 238-44; quiz 245-6.
Liu YJ. Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. J Allergy Clin Immunol. 2007;120(2):238-44; quiz 245-6.
Liu, Y. J. (2007). Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. The Journal of Allergy and Clinical Immunology, 120(2), 238-44; quiz 245-6.
Liu YJ. Thymic Stromal Lymphopoietin and OX40 Ligand Pathway in the Initiation of Dendritic Cell-mediated Allergic Inflammation. J Allergy Clin Immunol. 2007;120(2):238-44; quiz 245-6. PubMed PMID: 17666213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. A1 - Liu,Yong-Jun, PY - 2007/04/03/received PY - 2007/06/04/revised PY - 2007/06/04/accepted PY - 2007/8/2/pubmed PY - 2007/9/28/medline PY - 2007/8/2/entrez SP - 238-44; quiz 245-6 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 120 IS - 2 N2 - It was demonstrated 5 years ago that thymic stromal lymphopoietin (TSLP), a IL-7-like cytokine produced by epithelial cells, could strongly activate human myeloid dendritic cells to induce an inflammatory T(H)2 response characterized by high TNF-alpha and little IL-10 production, distinct from the regulatory T(H)2 responses characterized by low TNF-alpha and high IL-10 production. TSLP was found highly expressed by keratinocytes of skin lesions of atopic dermatitis and associated with dendritic cell activation in situ. This suggests for the first time that TSLP represents a master switch of allergic inflammation at the epithelial cell and dendritic cell interface. During the last several years, the evidence for the association of TSLP with human asthma was revealed. The direct link between TSLP expression with the pathogenesis of atopic dermatitis and asthma in vivo was demonstrated. In addition, OX40 ligand was found to be the TSLP-induced molecule on dendritic cells that triggers inflammatory T(H)2 differentiation in the absence of IL-12. TSLP was also demonstrated to direct the innate phase of allergic immune responses through activating mast cells. Therefore, TSLP and OX40 ligand may represent important targets for intervention of the initiation of allergic inflammatory responses. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/17666213/Thymic_stromal_lymphopoietin_and_OX40_ligand_pathway_in_the_initiation_of_dendritic_cell_mediated_allergic_inflammation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(07)01047-0 DB - PRIME DP - Unbound Medicine ER -