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Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women.
Ann Rheum Dis 2008; 67(4):530-5AR

Abstract

OBJECTIVES

Vitamin D has immune-modulating effects and may protect against the development of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

METHODS

We identified incident cases of SLE and RA among 186 389 women followed from 1980 to 2002 in the Nurses' Health Study and Nurses' Health Study II cohorts. We excluded subjects where SLE or RA was not confirmed by medical record review, and those who failed to return questionnaires. Semi-quantitative food frequency questionnaires assessed vitamin D intake from food and supplements. We used cumulative-updated total energy-adjusted dietary exposures for each 2-year cycle. Relationships between vitamin D intake and incident SLE and RA were examined in age-adjusted and Cox proportional hazards models, adjusted for confounders. Results were pooled using meta-analysis random effects models.

RESULTS

We confirmed 190 incident cases of SLE and 722 of RA with dietary information. Increasing levels of vitamin D intake had no relationship to the relative risk of developing either SLE or RA.

CONCLUSIONS

Vitamin D intake was not associated with risk of SLE or RA in these large prospective cohorts of women.

Authors+Show Affiliations

Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. KCostenbader@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17666449

Citation

Costenbader, K H., et al. "Vitamin D Intake and Risks of Systemic Lupus Erythematosus and Rheumatoid Arthritis in Women." Annals of the Rheumatic Diseases, vol. 67, no. 4, 2008, pp. 530-5.
Costenbader KH, Feskanich D, Holmes M, et al. Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women. Ann Rheum Dis. 2008;67(4):530-5.
Costenbader, K. H., Feskanich, D., Holmes, M., Karlson, E. W., & Benito-Garcia, E. (2008). Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women. Annals of the Rheumatic Diseases, 67(4), pp. 530-5.
Costenbader KH, et al. Vitamin D Intake and Risks of Systemic Lupus Erythematosus and Rheumatoid Arthritis in Women. Ann Rheum Dis. 2008;67(4):530-5. PubMed PMID: 17666449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women. AU - Costenbader,K H, AU - Feskanich,D, AU - Holmes,M, AU - Karlson,E W, AU - Benito-Garcia,E, Y1 - 2007/07/31/ PY - 2007/8/2/pubmed PY - 2008/4/17/medline PY - 2007/8/2/entrez SP - 530 EP - 5 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 67 IS - 4 N2 - OBJECTIVES: Vitamin D has immune-modulating effects and may protect against the development of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). METHODS: We identified incident cases of SLE and RA among 186 389 women followed from 1980 to 2002 in the Nurses' Health Study and Nurses' Health Study II cohorts. We excluded subjects where SLE or RA was not confirmed by medical record review, and those who failed to return questionnaires. Semi-quantitative food frequency questionnaires assessed vitamin D intake from food and supplements. We used cumulative-updated total energy-adjusted dietary exposures for each 2-year cycle. Relationships between vitamin D intake and incident SLE and RA were examined in age-adjusted and Cox proportional hazards models, adjusted for confounders. Results were pooled using meta-analysis random effects models. RESULTS: We confirmed 190 incident cases of SLE and 722 of RA with dietary information. Increasing levels of vitamin D intake had no relationship to the relative risk of developing either SLE or RA. CONCLUSIONS: Vitamin D intake was not associated with risk of SLE or RA in these large prospective cohorts of women. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/17666449/Vitamin_D_intake_and_risks_of_systemic_lupus_erythematosus_and_rheumatoid_arthritis_in_women_ L2 - https://ard.bmj.com/cgi/pmidlookup?view=long&pmid=17666449 DB - PRIME DP - Unbound Medicine ER -