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Symptoms associated with menopausal transition and reproductive hormones in midlife women.
Obstet Gynecol. 2007 Aug; 110(2 Pt 1):230-40.OG

Abstract

OBJECTIVE

To test the hypothesis that prevalence of women with menopausal symptoms of hot flushes; aches, joint pain, and stiffness; depressed mood; poor sleep; decreased libido; or vaginal dryness increases with progression through the menopausal transition.

METHODS

Women in the Penn Ovarian Aging Study were assessed longitudinally for 9 years. Data were obtained from structured interviews, a validated symptom questionnaire, menstrual bleeding dates and early follicular hormone measures (estradiol [E2], follicle-stimulating hormone [FSH], and inhibin b). Menopausal stages were based on menstrual bleeding patterns. Other risk factors included age, race, history of depression, current smoking, body mass index, and perceived stress. Generalized linear regression models for repeated measures were used to estimate associations among the variables with each symptom.

RESULTS

The prevalence of hot flushes; aches, joint pain, and stiffness; and depressed mood increased in the menopausal transition. Menopausal stage was associated with hot flushes (P<.001); aches joint pain, and stiffness (P<.001); and depressed mood (P=.002). Within-woman fluctuations of E2 were associated with hot flushes and aches. Poor sleep, decreased libido, and vaginal dryness were not associated with menopausal stages. There was 80% power to detect an absolute difference of 11% for libido and vaginal dryness and 17% for poor sleep in the prevalence of these symptoms in the late menopausal transition compared with premenopausal status.

CONCLUSION

The study highlights the role of menopausal stages for some symptoms of midlife women and indicates that stages in the transition to menopause are associated with hot flushes; aches, joint pain, and stiffness; and depressed mood. Fluctuations of E2, decreased levels of inhibin b, and increased FSH levels were associated with these symptoms.

LEVEL OF EVIDENCE

II.

Authors+Show Affiliations

Departments of Obstetrics/Gynecology, Psychiatry, University of Pennsylvania, 3701 Market Street, Philadelphia, PA 19104, USA. freemane@mail.med.upenn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17666595

Citation

Freeman, Ellen W., et al. "Symptoms Associated With Menopausal Transition and Reproductive Hormones in Midlife Women." Obstetrics and Gynecology, vol. 110, no. 2 Pt 1, 2007, pp. 230-40.
Freeman EW, Sammel MD, Lin H, et al. Symptoms associated with menopausal transition and reproductive hormones in midlife women. Obstet Gynecol. 2007;110(2 Pt 1):230-40.
Freeman, E. W., Sammel, M. D., Lin, H., Gracia, C. R., Pien, G. W., Nelson, D. B., & Sheng, L. (2007). Symptoms associated with menopausal transition and reproductive hormones in midlife women. Obstetrics and Gynecology, 110(2 Pt 1), 230-40.
Freeman EW, et al. Symptoms Associated With Menopausal Transition and Reproductive Hormones in Midlife Women. Obstet Gynecol. 2007;110(2 Pt 1):230-40. PubMed PMID: 17666595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Symptoms associated with menopausal transition and reproductive hormones in midlife women. AU - Freeman,Ellen W, AU - Sammel,Mary D, AU - Lin,Hui, AU - Gracia,Clarisa R, AU - Pien,Grace W, AU - Nelson,Deborah B, AU - Sheng,Li, PY - 2007/8/2/pubmed PY - 2007/8/31/medline PY - 2007/8/2/entrez SP - 230 EP - 40 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 110 IS - 2 Pt 1 N2 - OBJECTIVE: To test the hypothesis that prevalence of women with menopausal symptoms of hot flushes; aches, joint pain, and stiffness; depressed mood; poor sleep; decreased libido; or vaginal dryness increases with progression through the menopausal transition. METHODS: Women in the Penn Ovarian Aging Study were assessed longitudinally for 9 years. Data were obtained from structured interviews, a validated symptom questionnaire, menstrual bleeding dates and early follicular hormone measures (estradiol [E2], follicle-stimulating hormone [FSH], and inhibin b). Menopausal stages were based on menstrual bleeding patterns. Other risk factors included age, race, history of depression, current smoking, body mass index, and perceived stress. Generalized linear regression models for repeated measures were used to estimate associations among the variables with each symptom. RESULTS: The prevalence of hot flushes; aches, joint pain, and stiffness; and depressed mood increased in the menopausal transition. Menopausal stage was associated with hot flushes (P<.001); aches joint pain, and stiffness (P<.001); and depressed mood (P=.002). Within-woman fluctuations of E2 were associated with hot flushes and aches. Poor sleep, decreased libido, and vaginal dryness were not associated with menopausal stages. There was 80% power to detect an absolute difference of 11% for libido and vaginal dryness and 17% for poor sleep in the prevalence of these symptoms in the late menopausal transition compared with premenopausal status. CONCLUSION: The study highlights the role of menopausal stages for some symptoms of midlife women and indicates that stages in the transition to menopause are associated with hot flushes; aches, joint pain, and stiffness; and depressed mood. Fluctuations of E2, decreased levels of inhibin b, and increased FSH levels were associated with these symptoms. LEVEL OF EVIDENCE: II. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/17666595/Symptoms_associated_with_menopausal_transition_and_reproductive_hormones_in_midlife_women_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=17666595.ui DB - PRIME DP - Unbound Medicine ER -