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Bilateral neck node metastasis: a predictor of isolated distant metastasis in patients with oral and oropharyngeal squamous cell carcinoma after primary curative surgery.
Laryngoscope 2007; 117(9):1576-80L

Abstract

OBJECTIVES/HYPOTHESIS

The presence of distant metastasis after the initial treatment of oral and oropharyngeal squamous cell carcinoma (OOSCC) is often associated with a poor prognosis. The purpose of our study was to evaluate the frequency of isolated distant metastasis (IDM) that occurred without any local or regional failure, and to identify its predictive factors in patients who were surgically treated.

STUDY DESIGN

Retrospective chart review.

METHODS

We performed a retrospective analysis of 230 OOSCC patients who underwent surgical treatment of the primary lesion along with a simultaneous neck dissection between May 1992 and August 2004. We evaluated the frequency of IDMs without local or regional recurrences and the influence of different variables in their appearance.

RESULTS

The frequency of IDMs was 6%. Patients with oropharyngeal carcinoma had higher isolated distant failure compared with patients with oral cavity carcinoma (P<.05). In univariate analysis, the following conditions were significant predictors of IDM in patients with OOSCC: advanced local stage; clinical or pathologic positive neck node; the presence of more than two pathologic neck nodes; more than two bilateral pathologic nodal metastases; use of adjuvant radiotherapy; and advanced American Joint Committee on Cancer (AJCC) stage. However, in multivariate analysis, only the presence of pathologic positive lymph node, especially bilateral neck metastases, was an independent risk factor for the appearance of IDMs.

CONCLUSIONS

The incidence of IDMs in patients with OOSCC is relatively low. These events were significantly associated with bilateral neck node metastases.

Authors+Show Affiliations

Department of Otorhinolaryngology, Head and Neck Surgery, Konkuk University School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17667136

Citation

Lim, Young Chang, et al. "Bilateral Neck Node Metastasis: a Predictor of Isolated Distant Metastasis in Patients With Oral and Oropharyngeal Squamous Cell Carcinoma After Primary Curative Surgery." The Laryngoscope, vol. 117, no. 9, 2007, pp. 1576-80.
Lim YC, Koo BS, Choi EC. Bilateral neck node metastasis: a predictor of isolated distant metastasis in patients with oral and oropharyngeal squamous cell carcinoma after primary curative surgery. Laryngoscope. 2007;117(9):1576-80.
Lim, Y. C., Koo, B. S., & Choi, E. C. (2007). Bilateral neck node metastasis: a predictor of isolated distant metastasis in patients with oral and oropharyngeal squamous cell carcinoma after primary curative surgery. The Laryngoscope, 117(9), pp. 1576-80.
Lim YC, Koo BS, Choi EC. Bilateral Neck Node Metastasis: a Predictor of Isolated Distant Metastasis in Patients With Oral and Oropharyngeal Squamous Cell Carcinoma After Primary Curative Surgery. Laryngoscope. 2007;117(9):1576-80. PubMed PMID: 17667136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bilateral neck node metastasis: a predictor of isolated distant metastasis in patients with oral and oropharyngeal squamous cell carcinoma after primary curative surgery. AU - Lim,Young Chang, AU - Koo,Bon Seok, AU - Choi,Eun Chang, PY - 2007/8/2/pubmed PY - 2007/12/7/medline PY - 2007/8/2/entrez SP - 1576 EP - 80 JF - The Laryngoscope JO - Laryngoscope VL - 117 IS - 9 N2 - OBJECTIVES/HYPOTHESIS: The presence of distant metastasis after the initial treatment of oral and oropharyngeal squamous cell carcinoma (OOSCC) is often associated with a poor prognosis. The purpose of our study was to evaluate the frequency of isolated distant metastasis (IDM) that occurred without any local or regional failure, and to identify its predictive factors in patients who were surgically treated. STUDY DESIGN: Retrospective chart review. METHODS: We performed a retrospective analysis of 230 OOSCC patients who underwent surgical treatment of the primary lesion along with a simultaneous neck dissection between May 1992 and August 2004. We evaluated the frequency of IDMs without local or regional recurrences and the influence of different variables in their appearance. RESULTS: The frequency of IDMs was 6%. Patients with oropharyngeal carcinoma had higher isolated distant failure compared with patients with oral cavity carcinoma (P<.05). In univariate analysis, the following conditions were significant predictors of IDM in patients with OOSCC: advanced local stage; clinical or pathologic positive neck node; the presence of more than two pathologic neck nodes; more than two bilateral pathologic nodal metastases; use of adjuvant radiotherapy; and advanced American Joint Committee on Cancer (AJCC) stage. However, in multivariate analysis, only the presence of pathologic positive lymph node, especially bilateral neck metastases, was an independent risk factor for the appearance of IDMs. CONCLUSIONS: The incidence of IDMs in patients with OOSCC is relatively low. These events were significantly associated with bilateral neck node metastases. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/17667136/Bilateral_neck_node_metastasis:_a_predictor_of_isolated_distant_metastasis_in_patients_with_oral_and_oropharyngeal_squamous_cell_carcinoma_after_primary_curative_surgery_ L2 - https://doi.org/10.1097/MLG.0b013e318093ee2b DB - PRIME DP - Unbound Medicine ER -