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Magnesium metabolism in hypertension and type 2 diabetes mellitus.
Am J Ther. 2007 Jul-Aug; 14(4):375-85.AJ

Abstract

The increasing evidence for the clinical relevance of altered magnesium metabolism to states of altered insulin resistance confirms the role of magnesium deficit as a possible underlying common mechanism of the "insulin resistance" of hypertension and altered glucose tolerance. The pioneer work of Lawrence M. Resnick and his group using the cellular ion-based approach that we are only partially presenting here has consistently contributed to the progress of the field, demonstrating (a) the critical importance of magnesium metabolism in regulating insulin sensitivity as well as vascular tone, and blood-pressure homeostasis; (b) that magnesium deficiency, defined on the basis of intracellular free magnesium levels, and or serum ionized magnesium is a common feature of both diabetic and hypertensive states as well as various other cardiovascular and metabolic processes and aging; (c) the ability of environmental factors such as dietary nutrient-sugar and mineral content to alter the set point of steady-state cell ion activity; and (d) that magnesium supplementation is indicated in conditions associated with magnesium deficit although well-designed therapeutic trials of magnesium in essential hypertension and type 2 diabetes mellitus are needed in the near future.

Authors+Show Affiliations

Institute of Internal Medicine and Geriatrics, University of Palermo, Italy. mabar@unipa.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17667214

Citation

Barbagallo, Mario, et al. "Magnesium Metabolism in Hypertension and Type 2 Diabetes Mellitus." American Journal of Therapeutics, vol. 14, no. 4, 2007, pp. 375-85.
Barbagallo M, Dominguez LJ, Resnick LM. Magnesium metabolism in hypertension and type 2 diabetes mellitus. Am J Ther. 2007;14(4):375-85.
Barbagallo, M., Dominguez, L. J., & Resnick, L. M. (2007). Magnesium metabolism in hypertension and type 2 diabetes mellitus. American Journal of Therapeutics, 14(4), 375-85.
Barbagallo M, Dominguez LJ, Resnick LM. Magnesium Metabolism in Hypertension and Type 2 Diabetes Mellitus. Am J Ther. 2007;14(4):375-85. PubMed PMID: 17667214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium metabolism in hypertension and type 2 diabetes mellitus. AU - Barbagallo,Mario, AU - Dominguez,Ligia J, AU - Resnick,Lawrence M, PY - 2007/8/2/pubmed PY - 2007/10/10/medline PY - 2007/8/2/entrez SP - 375 EP - 85 JF - American journal of therapeutics JO - Am J Ther VL - 14 IS - 4 N2 - The increasing evidence for the clinical relevance of altered magnesium metabolism to states of altered insulin resistance confirms the role of magnesium deficit as a possible underlying common mechanism of the "insulin resistance" of hypertension and altered glucose tolerance. The pioneer work of Lawrence M. Resnick and his group using the cellular ion-based approach that we are only partially presenting here has consistently contributed to the progress of the field, demonstrating (a) the critical importance of magnesium metabolism in regulating insulin sensitivity as well as vascular tone, and blood-pressure homeostasis; (b) that magnesium deficiency, defined on the basis of intracellular free magnesium levels, and or serum ionized magnesium is a common feature of both diabetic and hypertensive states as well as various other cardiovascular and metabolic processes and aging; (c) the ability of environmental factors such as dietary nutrient-sugar and mineral content to alter the set point of steady-state cell ion activity; and (d) that magnesium supplementation is indicated in conditions associated with magnesium deficit although well-designed therapeutic trials of magnesium in essential hypertension and type 2 diabetes mellitus are needed in the near future. SN - 1075-2765 UR - https://www.unboundmedicine.com/medline/citation/17667214/Magnesium_metabolism_in_hypertension_and_type_2_diabetes_mellitus_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=17667214.ui DB - PRIME DP - Unbound Medicine ER -