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Impact of age older than 60 years in living donor liver transplantation.

Abstract

BACKGROUND

Living donor liver transplantation (LDLT) was extended to adults in recent years and more recently to older patients. The impact of donor age, analysis of preoperative risk factors for older LDLT recipients, and comparison of the complication rate between older and younger recipients were analyzed.

METHODS

Subjects included patients who underwent LDLT at Kyoto University Hospital from October 1996 to December 2005. Twenty-three donors were 60 years of age or older, and 411 were younger than 60 years of age. Fifty-two recipients were 60 years of age or older and 410 were younger than 60 years of age.

RESULTS

Postoperative recovery of liver function for donors and recipient/graft survival were not influenced by donor age. Hospital stay was longer in the donors 60 years of age or older than those younger than 60 years of age (P=0.02). The 5-year survival rates were 78.7% in recipients 60 years of age or older and 69.3% in younger recipients (P=0.26). Among preoperative risk factors for recipient survival rate, fulminant hepatic failure and preoperative status in the intensive care unit were significant (P<0.05). There were no significant differences in the incidence of postoperative complications for recipients.

CONCLUSIONS

Selected right lobe donors from individuals who were 60 years of age or older showed a similar postoperative course compared with younger donors. Moreover, LDLT is feasible for patients 60 years of age or older who do not require care in the intensive care unit or do not have fulminant hepatic failure.

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  • Authors+Show Affiliations

    ,

    Department of Transplant Surgery, Kyoto University Hospital, [corrected] Kyoto, Japan. kura3kaori@aol.com

    , , , , , , , ,

    Source

    Transplantation 84:2 2007 Jul 27 pg 166-72

    MeSH

    Adolescent
    Adult
    Age Factors
    Aged
    Follow-Up Studies
    Graft Survival
    Humans
    Liver Transplantation
    Living Donors
    Middle Aged
    Postoperative Complications
    Prognosis
    Proportional Hazards Models
    Retrospective Studies
    Risk Factors
    Survival Rate

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17667807

    Citation

    Kuramitsu, Kaori, et al. "Impact of Age Older Than 60 Years in Living Donor Liver Transplantation." Transplantation, vol. 84, no. 2, 2007, pp. 166-72.
    Kuramitsu K, Egawa H, Keeffe EB, et al. Impact of age older than 60 years in living donor liver transplantation. Transplantation. 2007;84(2):166-72.
    Kuramitsu, K., Egawa, H., Keeffe, E. B., Kasahara, M., Ito, T., Sakamoto, S., ... Uemoto, S. (2007). Impact of age older than 60 years in living donor liver transplantation. Transplantation, 84(2), pp. 166-72.
    Kuramitsu K, et al. Impact of Age Older Than 60 Years in Living Donor Liver Transplantation. Transplantation. 2007 Jul 27;84(2):166-72. PubMed PMID: 17667807.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impact of age older than 60 years in living donor liver transplantation. AU - Kuramitsu,Kaori, AU - Egawa,Hiroto, AU - Keeffe,Emmet B, AU - Kasahara,Mureo, AU - Ito,Takashi, AU - Sakamoto,Seisuke, AU - Ogawa,Kohei, AU - Oike,Fumitaka, AU - Takada,Yasutugu, AU - Uemoto,Shinji, PY - 2007/8/2/pubmed PY - 2007/8/29/medline PY - 2007/8/2/entrez SP - 166 EP - 72 JF - Transplantation JO - Transplantation VL - 84 IS - 2 N2 - BACKGROUND: Living donor liver transplantation (LDLT) was extended to adults in recent years and more recently to older patients. The impact of donor age, analysis of preoperative risk factors for older LDLT recipients, and comparison of the complication rate between older and younger recipients were analyzed. METHODS: Subjects included patients who underwent LDLT at Kyoto University Hospital from October 1996 to December 2005. Twenty-three donors were 60 years of age or older, and 411 were younger than 60 years of age. Fifty-two recipients were 60 years of age or older and 410 were younger than 60 years of age. RESULTS: Postoperative recovery of liver function for donors and recipient/graft survival were not influenced by donor age. Hospital stay was longer in the donors 60 years of age or older than those younger than 60 years of age (P=0.02). The 5-year survival rates were 78.7% in recipients 60 years of age or older and 69.3% in younger recipients (P=0.26). Among preoperative risk factors for recipient survival rate, fulminant hepatic failure and preoperative status in the intensive care unit were significant (P<0.05). There were no significant differences in the incidence of postoperative complications for recipients. CONCLUSIONS: Selected right lobe donors from individuals who were 60 years of age or older showed a similar postoperative course compared with younger donors. Moreover, LDLT is feasible for patients 60 years of age or older who do not require care in the intensive care unit or do not have fulminant hepatic failure. SN - 0041-1337 UR - https://www.unboundmedicine.com/medline/citation/17667807/Impact_of_age_older_than_60_years_in_living_donor_liver_transplantation_ L2 - http://Insights.ovid.com/pubmed?pmid=17667807 DB - PRIME DP - Unbound Medicine ER -