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Decreased interleukin-1beta and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis.
J Periodontol 2007; 78(8):1612-9JP

Abstract

BACKGROUND

The primary aim of this study was to compare the inflammatory activity in the gingival crevicular fluid (GCF) in a group of patients with rheumatoid arthritis (RA) and a group of matched controls. Secondarily, we aimed to evaluate the effect of rheumatologic treatment on periodontal inflammation.

METHODS

Seventeen individuals with RA with a mean duration of disease of 12.1 (+/- 9.9) years and the same number of systemically healthy individuals matched for age, gender, periodontal status, and tobacco use were selected. Medication data were registered, and GCF was collected by means of an intracrevicular washing method. Besides clinical registrations, periodontal inflammation was assessed by analysis of the cytokines interleukin (IL)-1beta and -18 and of elastase activity.

RESULTS

Amounts of IL-1beta and total elastase were significantly lower in the patient group. IL-1beta and total elastase had a significant and strong correlation in the RA group (r(s) = 0.883). This correlation was not observed in the control group.

CONCLUSION

The anti-inflammatory treatment taken by RA patients might influence the periodontal inflammation status represented by IL-1beta and elastase in the GCF.

Authors+Show Affiliations

Institute of Odontology, Division of Periodontology, Karolinska Institute, Huddinge, Sweden. leticia.miranda@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17668981

Citation

Miranda, Letícia A., et al. "Decreased Interleukin-1beta and Elastase in the Gingival Crevicular Fluid of Individuals Undergoing Anti-inflammatory Treatment for Rheumatoid Arthritis." Journal of Periodontology, vol. 78, no. 8, 2007, pp. 1612-9.
Miranda LA, Islabão AG, Fischer RG, et al. Decreased interleukin-1beta and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis. J Periodontol. 2007;78(8):1612-9.
Miranda, L. A., Islabão, A. G., Fischer, R. G., Figueredo, C. M., Oppermann, R. V., & Gustafsson, A. (2007). Decreased interleukin-1beta and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis. Journal of Periodontology, 78(8), pp. 1612-9.
Miranda LA, et al. Decreased Interleukin-1beta and Elastase in the Gingival Crevicular Fluid of Individuals Undergoing Anti-inflammatory Treatment for Rheumatoid Arthritis. J Periodontol. 2007;78(8):1612-9. PubMed PMID: 17668981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased interleukin-1beta and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis. AU - Miranda,Letícia A, AU - Islabão,Alexandre G, AU - Fischer,Ricardo G, AU - Figueredo,Carlos M S, AU - Oppermann,Rui V, AU - Gustafsson,Anders, PY - 2007/8/3/pubmed PY - 2008/6/7/medline PY - 2007/8/3/entrez SP - 1612 EP - 9 JF - Journal of periodontology JO - J. Periodontol. VL - 78 IS - 8 N2 - BACKGROUND: The primary aim of this study was to compare the inflammatory activity in the gingival crevicular fluid (GCF) in a group of patients with rheumatoid arthritis (RA) and a group of matched controls. Secondarily, we aimed to evaluate the effect of rheumatologic treatment on periodontal inflammation. METHODS: Seventeen individuals with RA with a mean duration of disease of 12.1 (+/- 9.9) years and the same number of systemically healthy individuals matched for age, gender, periodontal status, and tobacco use were selected. Medication data were registered, and GCF was collected by means of an intracrevicular washing method. Besides clinical registrations, periodontal inflammation was assessed by analysis of the cytokines interleukin (IL)-1beta and -18 and of elastase activity. RESULTS: Amounts of IL-1beta and total elastase were significantly lower in the patient group. IL-1beta and total elastase had a significant and strong correlation in the RA group (r(s) = 0.883). This correlation was not observed in the control group. CONCLUSION: The anti-inflammatory treatment taken by RA patients might influence the periodontal inflammation status represented by IL-1beta and elastase in the GCF. SN - 0022-3492 UR - https://www.unboundmedicine.com/medline/citation/17668981/Decreased_interleukin_1beta_and_elastase_in_the_gingival_crevicular_fluid_of_individuals_undergoing_anti_inflammatory_treatment_for_rheumatoid_arthritis_ L2 - https://doi.org/10.1902/jop.2007.060520 DB - PRIME DP - Unbound Medicine ER -