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Subchondral bone density and cartilage degeneration patterns in osteoarthritic metacarpal condyles of horses.
Am J Vet Res. 2007 Aug; 68(8):841-9.AJ

Abstract

OBJECTIVE

To evaluate and correlate patterns of subchondral bone density and articular cartilage degeneration (derived by use of gross, histologic, and computed tomographic [CT] examinations) in equine third metacarpal condyles with and without osteoarthritis.

SAMPLE POPULATION

8 metacarpophalangeal (MCP) joints (n = 4 horses) without osteoarthritis and 6 osteoarthritis-affected MCP joints (4).

PROCEDURES

Horses were euthanized. The third metacarpal condyles of the joints were examined grossly and via CT (3 slice images/condyle). For 6 condylar zones, mean bone density and pattern of density distribution were determined. Data for osteoarthritis-affected and control joints were compared. Histomorphometric point count analyses identified areas of bone density for comparison with CT density measurements.

RESULTS

Osteoarthritis-affected condyles had heterogeneous subchondral bone with focal resorptive lesions and patterned sclerosis, whereas control condyles had symmetric bone density distribution. In osteoarthritis-affected condyles, bone density determined via gray scale image density analysis was greater (dorsal and medial pattern), compared with control condyles, and differed among zones because of resorption and sclerosis. With regard to bone density in osteoarthritis-affected condyles, histologic findings correlated with CT images, and bone lesions were significantly correlated with cartilage lesions.

CONCLUSIONS AND CLINICAL RELEVANCE

In horses, heterogeneous distribution and greater subchondral bone density were characteristic of osteoarthritis-affected condyles, compared with control condyles. Subchondral bone lesions correlated with overlying cartilage lesions in osteoarthritis-affected MCP joints. Identification of CT image characteristics appears to predict the presence of a cartilage lesion in MCP joints of horses with osteoarthritis.

Authors+Show Affiliations

Comparative Orthopedic Research Laboratories, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17669024

Citation

Young, Benjamin D., et al. "Subchondral Bone Density and Cartilage Degeneration Patterns in Osteoarthritic Metacarpal Condyles of Horses." American Journal of Veterinary Research, vol. 68, no. 8, 2007, pp. 841-9.
Young BD, Samii VF, Mattoon JS, et al. Subchondral bone density and cartilage degeneration patterns in osteoarthritic metacarpal condyles of horses. Am J Vet Res. 2007;68(8):841-9.
Young, B. D., Samii, V. F., Mattoon, J. S., Weisbrode, S. E., & Bertone, A. L. (2007). Subchondral bone density and cartilage degeneration patterns in osteoarthritic metacarpal condyles of horses. American Journal of Veterinary Research, 68(8), 841-9.
Young BD, et al. Subchondral Bone Density and Cartilage Degeneration Patterns in Osteoarthritic Metacarpal Condyles of Horses. Am J Vet Res. 2007;68(8):841-9. PubMed PMID: 17669024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subchondral bone density and cartilage degeneration patterns in osteoarthritic metacarpal condyles of horses. AU - Young,Benjamin D, AU - Samii,Valerie F, AU - Mattoon,John S, AU - Weisbrode,Steven E, AU - Bertone,Alicia L, PY - 2007/8/3/pubmed PY - 2007/11/14/medline PY - 2007/8/3/entrez SP - 841 EP - 9 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 68 IS - 8 N2 - OBJECTIVE: To evaluate and correlate patterns of subchondral bone density and articular cartilage degeneration (derived by use of gross, histologic, and computed tomographic [CT] examinations) in equine third metacarpal condyles with and without osteoarthritis. SAMPLE POPULATION: 8 metacarpophalangeal (MCP) joints (n = 4 horses) without osteoarthritis and 6 osteoarthritis-affected MCP joints (4). PROCEDURES: Horses were euthanized. The third metacarpal condyles of the joints were examined grossly and via CT (3 slice images/condyle). For 6 condylar zones, mean bone density and pattern of density distribution were determined. Data for osteoarthritis-affected and control joints were compared. Histomorphometric point count analyses identified areas of bone density for comparison with CT density measurements. RESULTS: Osteoarthritis-affected condyles had heterogeneous subchondral bone with focal resorptive lesions and patterned sclerosis, whereas control condyles had symmetric bone density distribution. In osteoarthritis-affected condyles, bone density determined via gray scale image density analysis was greater (dorsal and medial pattern), compared with control condyles, and differed among zones because of resorption and sclerosis. With regard to bone density in osteoarthritis-affected condyles, histologic findings correlated with CT images, and bone lesions were significantly correlated with cartilage lesions. CONCLUSIONS AND CLINICAL RELEVANCE: In horses, heterogeneous distribution and greater subchondral bone density were characteristic of osteoarthritis-affected condyles, compared with control condyles. Subchondral bone lesions correlated with overlying cartilage lesions in osteoarthritis-affected MCP joints. Identification of CT image characteristics appears to predict the presence of a cartilage lesion in MCP joints of horses with osteoarthritis. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/17669024/Subchondral_bone_density_and_cartilage_degeneration_patterns_in_osteoarthritic_metacarpal_condyles_of_horses_ L2 - http://avmajournals.avma.org/doi/full/10.2460/ajvr.68.8.841?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -