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Role of saphenous vein wall in the pathogenesis of primary varicose veins.
Interact Cardiovasc Thorac Surg. 2007 Apr; 6(2):219-24.IC

Abstract

Varicose veins may be due to weakness of the vein wall as a result of structural problems. There are conflicting findings in the literature about these problems especially concerning collagen, elastin and smooth muscle cells content. The aim of this study was to look at the structural abnormalities of varicose veins (with and without valvular incompetence).

MATERIALS AND METHODS

We studied 70 specimens of long saphenous veins from 35 patients (24 with varicose and 11 with normal veins). Two specimens were taken from each vein approximately 3-4 cm from the saphenofemoral junction. Vein specimens were processed for histological and electron microscopic studies. Both qualitative and quantitative analyses were performed to assess the degree of wall changes. Using the image analyzer, contents of collagen, elastin and smooth muscle cells, in addition to intimal and medial thickness, were measured.

RESULTS

Light microscopy revealed significant increase in intimal and medial thickness and collagen content of media and significant decrease in elastin content in varicose veins compared with normal veins. There was no statistical significant difference between varicose veins with and without saphenofemoral valve incompetence. Electron microscopy showed marked degenerative changes in intima and media of varicose veins.

CONCLUSION

The findings in our study supported the theory of primary weakness of the vein wall as a cause of varicosity. This weakness is due to intimal changes, disturbance in the connective tissue components and smooth muscle cells.

Authors+Show Affiliations

Department of Surgery, College of Medicine, King Faisel University, P. O. Box 40081, Al-Khober, 31952, Eastern Province, Kingdom of Saudi Arabia. elsharawya@yahoo.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

17669815

Citation

Elsharawy, Mohamed A., et al. "Role of Saphenous Vein Wall in the Pathogenesis of Primary Varicose Veins." Interactive Cardiovascular and Thoracic Surgery, vol. 6, no. 2, 2007, pp. 219-24.
Elsharawy MA, Naim MM, Abdelmaguid EM, et al. Role of saphenous vein wall in the pathogenesis of primary varicose veins. Interact Cardiovasc Thorac Surg. 2007;6(2):219-24.
Elsharawy, M. A., Naim, M. M., Abdelmaguid, E. M., & Al-Mulhim, A. A. (2007). Role of saphenous vein wall in the pathogenesis of primary varicose veins. Interactive Cardiovascular and Thoracic Surgery, 6(2), 219-24.
Elsharawy MA, et al. Role of Saphenous Vein Wall in the Pathogenesis of Primary Varicose Veins. Interact Cardiovasc Thorac Surg. 2007;6(2):219-24. PubMed PMID: 17669815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of saphenous vein wall in the pathogenesis of primary varicose veins. AU - Elsharawy,Mohamed A, AU - Naim,Magda M, AU - Abdelmaguid,Eiman M, AU - Al-Mulhim,Abdulmohsen A, Y1 - 2006/12/01/ PY - 2007/8/3/pubmed PY - 2007/8/19/medline PY - 2007/8/3/entrez SP - 219 EP - 24 JF - Interactive cardiovascular and thoracic surgery JO - Interact Cardiovasc Thorac Surg VL - 6 IS - 2 N2 - UNLABELLED: Varicose veins may be due to weakness of the vein wall as a result of structural problems. There are conflicting findings in the literature about these problems especially concerning collagen, elastin and smooth muscle cells content. The aim of this study was to look at the structural abnormalities of varicose veins (with and without valvular incompetence). MATERIALS AND METHODS: We studied 70 specimens of long saphenous veins from 35 patients (24 with varicose and 11 with normal veins). Two specimens were taken from each vein approximately 3-4 cm from the saphenofemoral junction. Vein specimens were processed for histological and electron microscopic studies. Both qualitative and quantitative analyses were performed to assess the degree of wall changes. Using the image analyzer, contents of collagen, elastin and smooth muscle cells, in addition to intimal and medial thickness, were measured. RESULTS: Light microscopy revealed significant increase in intimal and medial thickness and collagen content of media and significant decrease in elastin content in varicose veins compared with normal veins. There was no statistical significant difference between varicose veins with and without saphenofemoral valve incompetence. Electron microscopy showed marked degenerative changes in intima and media of varicose veins. CONCLUSION: The findings in our study supported the theory of primary weakness of the vein wall as a cause of varicosity. This weakness is due to intimal changes, disturbance in the connective tissue components and smooth muscle cells. SN - 1569-9285 UR - https://www.unboundmedicine.com/medline/citation/17669815/Role_of_saphenous_vein_wall_in_the_pathogenesis_of_primary_varicose_veins_ L2 - https://academic.oup.com/icvts/article-lookup/doi/10.1510/icvts.2006.136937 DB - PRIME DP - Unbound Medicine ER -