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Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition cohort.
Am J Epidemiol 2007; 166(8):912-23AJ

Abstract

The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates p(heterogeneity) = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.

Authors+Show Affiliations

Nutrition and Hormones Unit, International Agency for Research on Cancer, Lyon, France. annec@health.usyd.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17670911

Citation

Cust, Anne E., et al. "Dietary Carbohydrates, Glycemic Index, Glycemic Load, and Endometrial Cancer Risk Within the European Prospective Investigation Into Cancer and Nutrition Cohort." American Journal of Epidemiology, vol. 166, no. 8, 2007, pp. 912-23.
Cust AE, Slimani N, Kaaks R, et al. Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition cohort. Am J Epidemiol. 2007;166(8):912-23.
Cust, A. E., Slimani, N., Kaaks, R., van Bakel, M., Biessy, C., Ferrari, P., ... Riboli, E. (2007). Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition cohort. American Journal of Epidemiology, 166(8), pp. 912-23.
Cust AE, et al. Dietary Carbohydrates, Glycemic Index, Glycemic Load, and Endometrial Cancer Risk Within the European Prospective Investigation Into Cancer and Nutrition Cohort. Am J Epidemiol. 2007 Oct 15;166(8):912-23. PubMed PMID: 17670911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition cohort. AU - Cust,Anne E, AU - Slimani,Nadia, AU - Kaaks,Rudolf, AU - van Bakel,Marit, AU - Biessy,Carine, AU - Ferrari,Pietro, AU - Laville,Martine, AU - Tjønneland,Anne, AU - Olsen,Anja, AU - Overvad,Kim, AU - Lajous,Martin, AU - Clavel-Chapelon,Francoise, AU - Boutron-Ruault,Marie-Christine, AU - Linseisen,Jakob, AU - Rohrmann,Sabine, AU - Nöthlings,Ute, AU - Boeing,Heiner, AU - Palli,Domenico, AU - Sieri,Sabina, AU - Panico,Salvatore, AU - Tumino,Rosario, AU - Sacerdote,Carlotta, AU - Skeie,Guri, AU - Engeset,Dagrun, AU - Gram,Inger Torhild, AU - Quirós,J Ramón, AU - Jakszyn,Paula, AU - Sánchez,María José, AU - Larrañaga,Nerea, AU - Navarro,Carmen, AU - Ardanaz,Eva, AU - Wirfält,Elisabet, AU - Berglund,Göran, AU - Lundin,Eva, AU - Hallmans,Göran, AU - Bueno-de-Mesquita,H Bas, AU - Du,Huaidong, AU - Peeters,Petra H M, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Allen,Naomi E, AU - Key,Timothy J, AU - Jenab,Mazda, AU - Riboli,Elio, Y1 - 2007/08/01/ PY - 2007/8/3/pubmed PY - 2007/11/10/medline PY - 2007/8/3/entrez SP - 912 EP - 23 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 166 IS - 8 N2 - The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates p(heterogeneity) = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17670911/Dietary_carbohydrates_glycemic_index_glycemic_load_and_endometrial_cancer_risk_within_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_cohort_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm161 DB - PRIME DP - Unbound Medicine ER -