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The 4G/4G plasminogen activator inhibitor-1 genotype is associated with frequent recurrence of acute otitis media.
Pediatrics. 2007 Aug; 120(2):e317-23.Ped

Abstract

OBJECTIVES

Plasminogen activator inhibitor-1 counterregulates cell migration, adhesion, and tissue repair. The PAI1 4G/5G promoter polymorphism has an effect on expression levels of PAI1. After a first acute otitis media episode, children are at increased risk for a next episode. Because the PAI1 4G allele is associated with higher plasminogen activator inhibitor-1 production and, hence, decreased tissue repair, we hypothesize that this allele may contribute to increased recurrence of acute otitis media.

PATIENTS AND METHODS

The PAI1 4G/5G polymorphism was genotyped in 348 Dutch children aged 1 to 7 years who were suffering from recurrent acute otitis media and participating in a randomized, controlled trial and 463 healthy control subjects, representative of the general population.

RESULTS

No significant difference in PAI1 genotype distribution between the whole acute otitis media group and control subjects was observed. However, children with the PAI1 4G/4G genotype had an increased risk of more frequent acute otitis media episodes compared with those who were homozygous for the 5G variant, also after correction for cofactors. This finding was attributable to children <4 years of age.

CONCLUSIONS

Our findings suggest that the PAI1 4G/4G genotype is associated with an increased risk for the otitis-prone condition, potentially because of impaired healing after a previous otitis media episode.

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Authors+Show Affiliations

Emonts M
Department of Pediatrics, Erasmus MC-Sophia Rotterdam, Dr Molewaterplein 50, Room Ee15-02, 3015 GE Rotterdam, The Netherlands. m.emonts@erasmusmc.nl
Wiertsema SP
No affiliation info available
Veenhoven RH
No affiliation info available
Houwing-Duistermaat JJ
No affiliation info available
Walraven V
No affiliation info available
de Groot R
No affiliation info available
Hermans PW
No affiliation info available
Sanders EA
No affiliation info available

MeSH

Acute DiseaseChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansInfantMaleOtitis MediaPlasminogen Activator Inhibitor 1Polymorphism, GeneticPromoter Regions, GeneticRecurrence

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17671042

Citation

Emonts, Marieke, et al. "The 4G/4G Plasminogen Activator Inhibitor-1 Genotype Is Associated With Frequent Recurrence of Acute Otitis Media." Pediatrics, vol. 120, no. 2, 2007, pp. e317-23.
Emonts M, Wiertsema SP, Veenhoven RH, et al. The 4G/4G plasminogen activator inhibitor-1 genotype is associated with frequent recurrence of acute otitis media. Pediatrics. 2007;120(2):e317-23.
Emonts, M., Wiertsema, S. P., Veenhoven, R. H., Houwing-Duistermaat, J. J., Walraven, V., de Groot, R., Hermans, P. W., & Sanders, E. A. (2007). The 4G/4G plasminogen activator inhibitor-1 genotype is associated with frequent recurrence of acute otitis media. Pediatrics, 120(2), e317-23.
Emonts M, et al. The 4G/4G Plasminogen Activator Inhibitor-1 Genotype Is Associated With Frequent Recurrence of Acute Otitis Media. Pediatrics. 2007;120(2):e317-23. PubMed PMID: 17671042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The 4G/4G plasminogen activator inhibitor-1 genotype is associated with frequent recurrence of acute otitis media. AU - Emonts,Marieke, AU - Wiertsema,Selma P, AU - Veenhoven,Reinier H, AU - Houwing-Duistermaat,Jeanine J, AU - Walraven,Vanessa, AU - de Groot,Ronald, AU - Hermans,Peter W M, AU - Sanders,Elisabeth A M, PY - 2007/8/3/pubmed PY - 2007/8/29/medline PY - 2007/8/3/entrez SP - e317 EP - 23 JF - Pediatrics JO - Pediatrics VL - 120 IS - 2 N2 - OBJECTIVES: Plasminogen activator inhibitor-1 counterregulates cell migration, adhesion, and tissue repair. The PAI1 4G/5G promoter polymorphism has an effect on expression levels of PAI1. After a first acute otitis media episode, children are at increased risk for a next episode. Because the PAI1 4G allele is associated with higher plasminogen activator inhibitor-1 production and, hence, decreased tissue repair, we hypothesize that this allele may contribute to increased recurrence of acute otitis media. PATIENTS AND METHODS: The PAI1 4G/5G polymorphism was genotyped in 348 Dutch children aged 1 to 7 years who were suffering from recurrent acute otitis media and participating in a randomized, controlled trial and 463 healthy control subjects, representative of the general population. RESULTS: No significant difference in PAI1 genotype distribution between the whole acute otitis media group and control subjects was observed. However, children with the PAI1 4G/4G genotype had an increased risk of more frequent acute otitis media episodes compared with those who were homozygous for the 5G variant, also after correction for cofactors. This finding was attributable to children <4 years of age. CONCLUSIONS: Our findings suggest that the PAI1 4G/4G genotype is associated with an increased risk for the otitis-prone condition, potentially because of impaired healing after a previous otitis media episode. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/17671042/The_4G/4G_plasminogen_activator_inhibitor_1_genotype_is_associated_with_frequent_recurrence_of_acute_otitis_media_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&amp;pmid=17671042 DB - PRIME DP - Unbound Medicine ER -