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FOXA1 expression in breast cancer--correlation with luminal subtype A and survival.
Clin Cancer Res. 2007 Aug 01; 13(15 Pt 1):4415-21.CC

Abstract

PURPOSE

FOXA1, a forkhead family transcription factor, is essential for optimum expression of approximately 50% of estrogen receptor alpha (ERalpha):estrogen responsive genes. FOXA1 is expressed in breast cancer cells. It segregates with genes that characterize the luminal subtypes in DNA microarray analyses. The utility of FOXA1 as a possible independent prognostic factor has not been determined in breast cancers.

MATERIALS AND METHODS

A tissue microarray comprising tumors from 438 patients with 15.4 years median follow-up was analyzed for FOXA1 expression by immunohistochemistry. Interpretable FOXA1 expression obtained in 404 patients was analyzed along with other prognostic factors like tumor grade, size, nodal status, ER, progesterone receptor (PR), and HER2/neu.

RESULTS

FOXA1 expression (score >3) was seen in 300 of 404 breast cancers and it correlated with ER (P = 0.000001), PR (P = 0.00001), and luminal A subtype (P = 0.000001). Loss of expression was noted with worsening tumor grade (P = 0.001). Univariate analysis showed nodal status (P = 0.0000012), tumor size (P = 0.00001), FOXA1 (P = 0.0004), and ER (P = 0.012) to be predictors of breast cancer-specific survival. Multivariate analysis showed only nodal status (P = 0.001) and tumor size (P = 0.039) to be significant prognostic factors, whereas FOXA1 (P = 0.060) and ER (P = 0.131) were not significant. In luminal subtype A patient subgroup, FOXA1 expression was associated with better cancer-specific survival (P = 0.024) and in ER-positive subgroup, it was better predictor of cancer-specific survival (P = 0.009) than PR (P = 0.213).

CONCLUSION

FOXA1 expression correlates with luminal subtype A breast cancer and it is significant predictor of cancer-specific survival in patients with ER-positive tumors. Prognostic ability of FOXA1 in these low-risk breast cancers may prove to be useful in clinical treatment decisions.

Authors+Show Affiliations

Department of Pathology, Indiana University School of Medicine, Indianapolis, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17671124

Citation

Badve, Sunil, et al. "FOXA1 Expression in Breast Cancer--correlation With Luminal Subtype a and Survival." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 13, no. 15 Pt 1, 2007, pp. 4415-21.
Badve S, Turbin D, Thorat MA, et al. FOXA1 expression in breast cancer--correlation with luminal subtype A and survival. Clin Cancer Res. 2007;13(15 Pt 1):4415-21.
Badve, S., Turbin, D., Thorat, M. A., Morimiya, A., Nielsen, T. O., Perou, C. M., Dunn, S., Huntsman, D. G., & Nakshatri, H. (2007). FOXA1 expression in breast cancer--correlation with luminal subtype A and survival. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 13(15 Pt 1), 4415-21.
Badve S, et al. FOXA1 Expression in Breast Cancer--correlation With Luminal Subtype a and Survival. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4415-21. PubMed PMID: 17671124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FOXA1 expression in breast cancer--correlation with luminal subtype A and survival. AU - Badve,Sunil, AU - Turbin,Dmitry, AU - Thorat,Mangesh A, AU - Morimiya,Akira, AU - Nielsen,Torsten O, AU - Perou,Charles M, AU - Dunn,Sandi, AU - Huntsman,David G, AU - Nakshatri,Harikrishna, PY - 2007/8/3/pubmed PY - 2007/10/30/medline PY - 2007/8/3/entrez SP - 4415 EP - 21 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin Cancer Res VL - 13 IS - 15 Pt 1 N2 - PURPOSE: FOXA1, a forkhead family transcription factor, is essential for optimum expression of approximately 50% of estrogen receptor alpha (ERalpha):estrogen responsive genes. FOXA1 is expressed in breast cancer cells. It segregates with genes that characterize the luminal subtypes in DNA microarray analyses. The utility of FOXA1 as a possible independent prognostic factor has not been determined in breast cancers. MATERIALS AND METHODS: A tissue microarray comprising tumors from 438 patients with 15.4 years median follow-up was analyzed for FOXA1 expression by immunohistochemistry. Interpretable FOXA1 expression obtained in 404 patients was analyzed along with other prognostic factors like tumor grade, size, nodal status, ER, progesterone receptor (PR), and HER2/neu. RESULTS: FOXA1 expression (score >3) was seen in 300 of 404 breast cancers and it correlated with ER (P = 0.000001), PR (P = 0.00001), and luminal A subtype (P = 0.000001). Loss of expression was noted with worsening tumor grade (P = 0.001). Univariate analysis showed nodal status (P = 0.0000012), tumor size (P = 0.00001), FOXA1 (P = 0.0004), and ER (P = 0.012) to be predictors of breast cancer-specific survival. Multivariate analysis showed only nodal status (P = 0.001) and tumor size (P = 0.039) to be significant prognostic factors, whereas FOXA1 (P = 0.060) and ER (P = 0.131) were not significant. In luminal subtype A patient subgroup, FOXA1 expression was associated with better cancer-specific survival (P = 0.024) and in ER-positive subgroup, it was better predictor of cancer-specific survival (P = 0.009) than PR (P = 0.213). CONCLUSION: FOXA1 expression correlates with luminal subtype A breast cancer and it is significant predictor of cancer-specific survival in patients with ER-positive tumors. Prognostic ability of FOXA1 in these low-risk breast cancers may prove to be useful in clinical treatment decisions. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/17671124/FOXA1_expression_in_breast_cancer__correlation_with_luminal_subtype_A_and_survival_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17671124 DB - PRIME DP - Unbound Medicine ER -