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Lymphocytes, neuropeptides, and genes involved in alopecia areata.
J Clin Invest. 2007 Aug; 117(8):2019-27.JCI

Abstract

Many lessons in autoimmunity - particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology - can be learned from the study of alopecia areata, the most common cause of inflammation-induced hair loss. Alopecia areata is now understood to represent an organ-restricted, T cell-mediated autoimmune disease of hair follicles. Disease induction is associated with collapse of hair follicle immune privilege in both humans and in animal models. Here, the role of HLA associations, other immunogenetic factors, and neuroendocrine parameters in alopecia areata pathogenesis are reviewed. This instructive and clinically significant model disease deserves more widespread interest in the immunology community.

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Authors+Show Affiliations

Gilhar A
Skin Research Laboratory, The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology and Flieman Medical Center, Haifa, Israel.
Paus R
No affiliation info available
Kalish RS
No affiliation info available

MeSH

Alopecia AreataAnimalsAutoimmune DiseasesDisease Models, AnimalHLA AntigensHair FollicleHumansInflammationNeuropeptidesNeurosecretory SystemsOrgan SpecificityT-Lymphocytes

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17671634

Clinical Trial Links

Efficacy of Combined Microneedling With Methotrexate in Treatment of Alopecia Areata
Cryotherapy Versus Steroids In Alopecia Areata:Trichoscopic Evaluation

Citation

Gilhar, Amos, et al. "Lymphocytes, Neuropeptides, and Genes Involved in Alopecia Areata." The Journal of Clinical Investigation, vol. 117, no. 8, 2007, pp. 2019-27.
Gilhar A, Paus R, Kalish RS. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest. 2007;117(8):2019-27.
Gilhar, A., Paus, R., & Kalish, R. S. (2007). Lymphocytes, neuropeptides, and genes involved in alopecia areata. The Journal of Clinical Investigation, 117(8), 2019-27.
Gilhar A, Paus R, Kalish RS. Lymphocytes, Neuropeptides, and Genes Involved in Alopecia Areata. J Clin Invest. 2007;117(8):2019-27. PubMed PMID: 17671634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphocytes, neuropeptides, and genes involved in alopecia areata. AU - Gilhar,Amos, AU - Paus,Ralf, AU - Kalish,Richard S, PY - 2007/8/3/pubmed PY - 2007/10/5/medline PY - 2007/8/3/entrez SP - 2019 EP - 27 JF - The Journal of clinical investigation JO - J Clin Invest VL - 117 IS - 8 N2 - Many lessons in autoimmunity - particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology - can be learned from the study of alopecia areata, the most common cause of inflammation-induced hair loss. Alopecia areata is now understood to represent an organ-restricted, T cell-mediated autoimmune disease of hair follicles. Disease induction is associated with collapse of hair follicle immune privilege in both humans and in animal models. Here, the role of HLA associations, other immunogenetic factors, and neuroendocrine parameters in alopecia areata pathogenesis are reviewed. This instructive and clinically significant model disease deserves more widespread interest in the immunology community. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/17671634/Lymphocytes_neuropeptides_and_genes_involved_in_alopecia_areata_ L2 - https://doi.org/10.1172/JCI31942 DB - PRIME DP - Unbound Medicine ER -