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CCR5-Delta32 genetic polymorphism associated with benign clinical course and magnetic resonance imaging findings in Brazilian patients with multiple sclerosis.
Int J Mol Med 2007; 20(3):337-44IJ

Abstract

The CCR5 chemokine receptor has been implicated in the pathogenesis of multiple sclerosis (MS). This research was carried out to investigate the association between the CCR5-Delta32 deletion in 124 patients with MS from Southern Brazil. Ninety-eight (79.0%) patients presented with relapsing-remitting MS (RR-MS), 17 (13.7%) secondary progressive MS (SP-MS), 8 (6.5%) primary progressive MS (PP-MS) and one (0.8%) clinically isolated syndrome (CIS). The control group consisted of 127 healthy blood donors from the same geographic region. The disease severity was assessed clinically using the Expanded Disability Status Scale (EDSS). Genomic DNA was extracted from peripheral blood cells and the genetic polymorphism was evaluated by polymerase chain reaction. Of the MS patients, 85 (68.5%) were females (p=0.0093). The CCR5-Delta32 frequency among the controls was 5.5%, and did not differ from that observed among the MS patients (4.8%) (p=0.7337). The mean (+/-SD) age at disease onset among the carriers and non-carriers of the CCR5-Delta32 allele was 31.7 (+/-11.1) and 36.6 (+/-12.0) years, respectively (p=0.1312). The duration (+/-SD) of the disease was 11.2 (+/-12.9) and 7.7 (+/- 5.6) years among the CCR5-Delta32 heterozygous, and CCR5 wild type, respectively (p=0.396). The mean (+/-SD) EDSS among the MS patients carriers and non-carriers of the CCR5-Delta32 allele was 2.4+/-1.2 and 2.67+/-2.2, respectively (p=0.9796). The MRI findings in MS patients with the CCR5-Delta32 genotype exhibited lower positive gadolinium enhancing-imaging (p=0.0013) and lower brain atrophy (p=0.1333) than MS patients with the CCR5 wild-type genotype. Despite that the differences were not significant, the results suggested that the disease onset and progression to disability may be prolonged in MS carriers of CCR5-Delta32, and CCR5-Delta32 could be considered a favorable prognostic biomarker of MS. Further studies comprising larger numbers of individuals carrying non-wild-type haplotypes are needed to determine CCR5-Delta32 involvement in the specific process of MS pathology and pathogenesis.

Authors+Show Affiliations

Department of Clinical Medicine, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17671738

Citation

Kaimen-Maciel, Damacio Ramón, et al. "CCR5-Delta32 Genetic Polymorphism Associated With Benign Clinical Course and Magnetic Resonance Imaging Findings in Brazilian Patients With Multiple Sclerosis." International Journal of Molecular Medicine, vol. 20, no. 3, 2007, pp. 337-44.
Kaimen-Maciel DR, Reiche EM, Brum Souza DG, et al. CCR5-Delta32 genetic polymorphism associated with benign clinical course and magnetic resonance imaging findings in Brazilian patients with multiple sclerosis. Int J Mol Med. 2007;20(3):337-44.
Kaimen-Maciel, D. R., Reiche, E. M., Brum Souza, D. G., Frota Comini, E. R., Bobroff, F., Morimoto, H. K., ... Donadi, E. A. (2007). CCR5-Delta32 genetic polymorphism associated with benign clinical course and magnetic resonance imaging findings in Brazilian patients with multiple sclerosis. International Journal of Molecular Medicine, 20(3), pp. 337-44.
Kaimen-Maciel DR, et al. CCR5-Delta32 Genetic Polymorphism Associated With Benign Clinical Course and Magnetic Resonance Imaging Findings in Brazilian Patients With Multiple Sclerosis. Int J Mol Med. 2007;20(3):337-44. PubMed PMID: 17671738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CCR5-Delta32 genetic polymorphism associated with benign clinical course and magnetic resonance imaging findings in Brazilian patients with multiple sclerosis. AU - Kaimen-Maciel,Damacio Ramón, AU - Reiche,Edna Maria Vissoci, AU - Brum Souza,Doralina Guimarães, AU - Frota Comini,Elisabeth Regina, AU - Bobroff,Flavio, AU - Morimoto,Helena Kaminami, AU - Ehara Watanabe,Maria Angélica, AU - Carvalho De Oliveira,Jaqueline, AU - Matsuo,Tiemi, AU - Lopes,Josiane, AU - Donadi,Eduardo Antonio, PY - 2007/8/3/pubmed PY - 2007/10/12/medline PY - 2007/8/3/entrez SP - 337 EP - 44 JF - International journal of molecular medicine JO - Int. J. Mol. Med. VL - 20 IS - 3 N2 - The CCR5 chemokine receptor has been implicated in the pathogenesis of multiple sclerosis (MS). This research was carried out to investigate the association between the CCR5-Delta32 deletion in 124 patients with MS from Southern Brazil. Ninety-eight (79.0%) patients presented with relapsing-remitting MS (RR-MS), 17 (13.7%) secondary progressive MS (SP-MS), 8 (6.5%) primary progressive MS (PP-MS) and one (0.8%) clinically isolated syndrome (CIS). The control group consisted of 127 healthy blood donors from the same geographic region. The disease severity was assessed clinically using the Expanded Disability Status Scale (EDSS). Genomic DNA was extracted from peripheral blood cells and the genetic polymorphism was evaluated by polymerase chain reaction. Of the MS patients, 85 (68.5%) were females (p=0.0093). The CCR5-Delta32 frequency among the controls was 5.5%, and did not differ from that observed among the MS patients (4.8%) (p=0.7337). The mean (+/-SD) age at disease onset among the carriers and non-carriers of the CCR5-Delta32 allele was 31.7 (+/-11.1) and 36.6 (+/-12.0) years, respectively (p=0.1312). The duration (+/-SD) of the disease was 11.2 (+/-12.9) and 7.7 (+/- 5.6) years among the CCR5-Delta32 heterozygous, and CCR5 wild type, respectively (p=0.396). The mean (+/-SD) EDSS among the MS patients carriers and non-carriers of the CCR5-Delta32 allele was 2.4+/-1.2 and 2.67+/-2.2, respectively (p=0.9796). The MRI findings in MS patients with the CCR5-Delta32 genotype exhibited lower positive gadolinium enhancing-imaging (p=0.0013) and lower brain atrophy (p=0.1333) than MS patients with the CCR5 wild-type genotype. Despite that the differences were not significant, the results suggested that the disease onset and progression to disability may be prolonged in MS carriers of CCR5-Delta32, and CCR5-Delta32 could be considered a favorable prognostic biomarker of MS. Further studies comprising larger numbers of individuals carrying non-wild-type haplotypes are needed to determine CCR5-Delta32 involvement in the specific process of MS pathology and pathogenesis. SN - 1107-3756 UR - https://www.unboundmedicine.com/medline/citation/17671738/CCR5_Delta32_genetic_polymorphism_associated_with_benign_clinical_course_and_magnetic_resonance_imaging_findings_in_Brazilian_patients_with_multiple_sclerosis_ L2 - http://www.spandidos-publications.com/ijmm/20/3/337 DB - PRIME DP - Unbound Medicine ER -