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Eremophilane sesquiterpenes from Ligularia macrophylla.
J Nat Prod. 2007 Aug; 70(8):1259-62.JN

Abstract

New eremophilane sesquiterpenes, 6beta-sarracinoyloxy-1beta,10beta-epoxy-furanoeremophilane (1), 6alpha-angeloyloxy-10betaH-furanoeremophil-1-one (2), 1alpha-hydroxy-9-deoxycacalol (3), and 1beta-hydroxy-11(R,S)-8-oxoeremophil-6,9-dien-12-al (4a+4b), together with five known sesquiterpenes (5-9) were isolated from the roots and rhizomes of Ligularia macrophylla. The structures were elucidated by spectroscopic methods including 2D NMR techniques, and the structure of 1 was confirmed by a single-crystal X-ray diffraction experiment. The compounds were also evaluated for cytotoxic activity against human lung carcinoma (A-549) and human breast adenocarcinoma (MCF-7) and were found to show only very weak cytotoxicity.

Authors+Show Affiliations

Wang Q
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, People's Republic of China.
Mu Q
No affiliation info available
Shibano M
No affiliation info available
Morris-Natschke SL
No affiliation info available
Lee KH
No affiliation info available
Chen DF
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicAsteraceaeCrystallography, X-RayDrug Screening Assays, AntitumorDrugs, Chinese HerbalFemaleHumansMolecular ConformationMolecular StructureNaphthalenesPlant RootsPlants, MedicinalPolycyclic SesquiterpenesRhizomeSesquiterpenes

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17672504

Citation

Wang, Qi, et al. "Eremophilane Sesquiterpenes From Ligularia Macrophylla." Journal of Natural Products, vol. 70, no. 8, 2007, pp. 1259-62.
Wang Q, Mu Q, Shibano M, et al. Eremophilane sesquiterpenes from Ligularia macrophylla. J Nat Prod. 2007;70(8):1259-62.
Wang, Q., Mu, Q., Shibano, M., Morris-Natschke, S. L., Lee, K. H., & Chen, D. F. (2007). Eremophilane sesquiterpenes from Ligularia macrophylla. Journal of Natural Products, 70(8), 1259-62.
Wang Q, et al. Eremophilane Sesquiterpenes From Ligularia Macrophylla. J Nat Prod. 2007;70(8):1259-62. PubMed PMID: 17672504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eremophilane sesquiterpenes from Ligularia macrophylla. AU - Wang,Qi, AU - Mu,Qing, AU - Shibano,Makio, AU - Morris-Natschke,Susan L, AU - Lee,Kuo-Hsiung, AU - Chen,Dao-Feng, Y1 - 2007/08/02/ PY - 2007/8/4/pubmed PY - 2007/10/5/medline PY - 2007/8/4/entrez SP - 1259 EP - 62 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 8 N2 - New eremophilane sesquiterpenes, 6beta-sarracinoyloxy-1beta,10beta-epoxy-furanoeremophilane (1), 6alpha-angeloyloxy-10betaH-furanoeremophil-1-one (2), 1alpha-hydroxy-9-deoxycacalol (3), and 1beta-hydroxy-11(R,S)-8-oxoeremophil-6,9-dien-12-al (4a+4b), together with five known sesquiterpenes (5-9) were isolated from the roots and rhizomes of Ligularia macrophylla. The structures were elucidated by spectroscopic methods including 2D NMR techniques, and the structure of 1 was confirmed by a single-crystal X-ray diffraction experiment. The compounds were also evaluated for cytotoxic activity against human lung carcinoma (A-549) and human breast adenocarcinoma (MCF-7) and were found to show only very weak cytotoxicity. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17672504/Eremophilane_sesquiterpenes_from_Ligularia_macrophylla_ L2 - https://doi.org/10.1021/np070113x DB - PRIME DP - Unbound Medicine ER -