Tags

Type your tag names separated by a space and hit enter

Epidemiologic studies of environmental exposures in Parkinson's disease.
J Neurol Sci. 2007 Nov 15; 262(1-2):37-44.JN

Abstract

Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease. Because of the ageing of Western populations, an increasing number of persons will be affected with PD in the future and neither curative treatments nor preventive measures have been identified. PD is considered as a multifactorial disease, resulting from the effect of environmental factors and genetic susceptibility. Increasing age and male sex appear to be associated with an increased risk of PD. In addition, recent epidemiological studies have identified environmental exposures that influence the risk of PD. This review provides an overview of the epidemiologic evidence for environmental etiologies in PD; we will focus on two environmental exposures that have been quite consistently associated with PD -- cigarette smoking and pesticide exposure -- and will summarize briefly the findings for other exposures. Understanding the mechanisms underlying these epidemiological associations is an essential step for the understanding of the etiology of this neurodegenerative condition and, ideally, to develop neuroprotective drugs.

Authors+Show Affiliations

Inserm, U708, Neuroepidemiology, Hôpital de la Salpêtrière, Paris, France. elbaz@chups.jussieu.frNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17673256

Citation

Elbaz, Alexis, and Christine Tranchant. "Epidemiologic Studies of Environmental Exposures in Parkinson's Disease." Journal of the Neurological Sciences, vol. 262, no. 1-2, 2007, pp. 37-44.
Elbaz A, Tranchant C. Epidemiologic studies of environmental exposures in Parkinson's disease. J Neurol Sci. 2007;262(1-2):37-44.
Elbaz, A., & Tranchant, C. (2007). Epidemiologic studies of environmental exposures in Parkinson's disease. Journal of the Neurological Sciences, 262(1-2), 37-44.
Elbaz A, Tranchant C. Epidemiologic Studies of Environmental Exposures in Parkinson's Disease. J Neurol Sci. 2007 Nov 15;262(1-2):37-44. PubMed PMID: 17673256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiologic studies of environmental exposures in Parkinson's disease. AU - Elbaz,Alexis, AU - Tranchant,Christine, Y1 - 2007/07/27/ PY - 2007/8/4/pubmed PY - 2007/12/19/medline PY - 2007/8/4/entrez SP - 37 EP - 44 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 262 IS - 1-2 N2 - Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease. Because of the ageing of Western populations, an increasing number of persons will be affected with PD in the future and neither curative treatments nor preventive measures have been identified. PD is considered as a multifactorial disease, resulting from the effect of environmental factors and genetic susceptibility. Increasing age and male sex appear to be associated with an increased risk of PD. In addition, recent epidemiological studies have identified environmental exposures that influence the risk of PD. This review provides an overview of the epidemiologic evidence for environmental etiologies in PD; we will focus on two environmental exposures that have been quite consistently associated with PD -- cigarette smoking and pesticide exposure -- and will summarize briefly the findings for other exposures. Understanding the mechanisms underlying these epidemiological associations is an essential step for the understanding of the etiology of this neurodegenerative condition and, ideally, to develop neuroprotective drugs. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/17673256/Epidemiologic_studies_of_environmental_exposures_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(07)00438-8 DB - PRIME DP - Unbound Medicine ER -