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Influence of acclimation and cross-acclimation of metals on acute Cd toxicity and Cd uptake and distribution in rainbow trout (Oncorhynchus mykiss).
Aquat Toxicol. 2007 Aug 30; 84(2):190-7.AT

Abstract

The development of chronic metal toxicity models for fresh water fish is complicated by the physiological adjustments made by the animal during exposure which results in acclimation. This study examines the influence of a pre-exposure to a chronic sublethal waterborne metal on acclimation responses as well as the uptake and distribution of new metal into juvenile rainbow trout. In one series of tests, trout were exposed to either 20 or 60 microg/L Cu, or 150 microg/L Zn for a month in moderately hard water and then cross-acclimation responses to Cd were measured in 96 h LC(50) tests. Cu exposed trout showed a cross-acclimation response but Zn exposed trout did not. Using these results, a detailed examination of Cd uptake and tissue distribution in metal-acclimated trout was done. Trout were exposed to either 75 microg/L Cu or 3 microg/L Cd for 1 month to induce acclimation and subsequently, the uptake and distribution of new Cd was assessed in both Cd- and Cu-acclimated fish using (109)Cd. The pattern of accumulation of new metal was dramatically altered in acclimated fish. For example, in 3 h gill Cd binding experiments, Cd- and Cu-acclimated trout both had a higher capacity to accumulate new Cd but only Cu-acclimated fish showed a higher affinity for Cd compared to unexposed controls. Experiments measuring Cd uptake over 72 h at 3 microgCd/L showed that the Cd uptake rate was lower for Cd-acclimated fish compared to both Cu-acclimated fish and unexposed controls. The results demonstrate the phenomenon of cross-acclimation to Cd and that chronic sublethal exposure to one metal can alter the uptake and tissue distribution of another. Understanding how acclimation influences toxicity and bioaccumulation is important in the context of risk assessment. This study illustrates that knowledge of previous exposure conditions is essential, not only for the metal of concern, but also for other metals as well.

Authors+Show Affiliations

Department of Biology, Wilfrid Laurier University, 75 University Avenue W, Waterloo, ON, N2L 3C5, Canada. jmcgeer@wlu.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17673308

Citation

McGeer, James C., et al. "Influence of Acclimation and Cross-acclimation of Metals On Acute Cd Toxicity and Cd Uptake and Distribution in Rainbow Trout (Oncorhynchus Mykiss)." Aquatic Toxicology (Amsterdam, Netherlands), vol. 84, no. 2, 2007, pp. 190-7.
McGeer JC, Nadella S, Alsop DH, et al. Influence of acclimation and cross-acclimation of metals on acute Cd toxicity and Cd uptake and distribution in rainbow trout (Oncorhynchus mykiss). Aquat Toxicol. 2007;84(2):190-7.
McGeer, J. C., Nadella, S., Alsop, D. H., Hollis, L., Taylor, L. N., McDonald, D. G., & Wood, C. M. (2007). Influence of acclimation and cross-acclimation of metals on acute Cd toxicity and Cd uptake and distribution in rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology (Amsterdam, Netherlands), 84(2), 190-7.
McGeer JC, et al. Influence of Acclimation and Cross-acclimation of Metals On Acute Cd Toxicity and Cd Uptake and Distribution in Rainbow Trout (Oncorhynchus Mykiss). Aquat Toxicol. 2007 Aug 30;84(2):190-7. PubMed PMID: 17673308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of acclimation and cross-acclimation of metals on acute Cd toxicity and Cd uptake and distribution in rainbow trout (Oncorhynchus mykiss). AU - McGeer,James C, AU - Nadella,Sunita, AU - Alsop,Derek H, AU - Hollis,Lydia, AU - Taylor,Lisa N, AU - McDonald,D Gordon, AU - Wood,Chris M, Y1 - 2007/06/16/ PY - 2006/12/15/received PY - 2007/03/15/revised PY - 2007/03/16/accepted PY - 2007/8/4/pubmed PY - 2007/12/6/medline PY - 2007/8/4/entrez SP - 190 EP - 7 JF - Aquatic toxicology (Amsterdam, Netherlands) JO - Aquat Toxicol VL - 84 IS - 2 N2 - The development of chronic metal toxicity models for fresh water fish is complicated by the physiological adjustments made by the animal during exposure which results in acclimation. This study examines the influence of a pre-exposure to a chronic sublethal waterborne metal on acclimation responses as well as the uptake and distribution of new metal into juvenile rainbow trout. In one series of tests, trout were exposed to either 20 or 60 microg/L Cu, or 150 microg/L Zn for a month in moderately hard water and then cross-acclimation responses to Cd were measured in 96 h LC(50) tests. Cu exposed trout showed a cross-acclimation response but Zn exposed trout did not. Using these results, a detailed examination of Cd uptake and tissue distribution in metal-acclimated trout was done. Trout were exposed to either 75 microg/L Cu or 3 microg/L Cd for 1 month to induce acclimation and subsequently, the uptake and distribution of new Cd was assessed in both Cd- and Cu-acclimated fish using (109)Cd. The pattern of accumulation of new metal was dramatically altered in acclimated fish. For example, in 3 h gill Cd binding experiments, Cd- and Cu-acclimated trout both had a higher capacity to accumulate new Cd but only Cu-acclimated fish showed a higher affinity for Cd compared to unexposed controls. Experiments measuring Cd uptake over 72 h at 3 microgCd/L showed that the Cd uptake rate was lower for Cd-acclimated fish compared to both Cu-acclimated fish and unexposed controls. The results demonstrate the phenomenon of cross-acclimation to Cd and that chronic sublethal exposure to one metal can alter the uptake and tissue distribution of another. Understanding how acclimation influences toxicity and bioaccumulation is important in the context of risk assessment. This study illustrates that knowledge of previous exposure conditions is essential, not only for the metal of concern, but also for other metals as well. SN - 0166-445X UR - https://www.unboundmedicine.com/medline/citation/17673308/Influence_of_acclimation_and_cross_acclimation_of_metals_on_acute_Cd_toxicity_and_Cd_uptake_and_distribution_in_rainbow_trout__Oncorhynchus_mykiss__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-445X(07)00223-8 DB - PRIME DP - Unbound Medicine ER -