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The nutritional and metabolic indices in rats fed cholesterol-containing diets supplemented with durian at different stages of ripening.
Biofactors. 2007; 29(2-3):123-36.B

Abstract

The aim of this investigation was to assess the nutritional and health properties of Mon Thong durian cultivar at different stages of ripening. The assessment was carried out in vitro and in vivo. The contents of dietary fibers, minerals and trace metals at different stages of ripening were comparable. Total polyphenols (mgGAE/100 g FW) and flavonoids (mg CE/100 gFW) in ripe durian (358.8 +/- 31.4 and 95.4 +/- 9.3) were significantly higher (p < 0.05) than in mature (216.1 +/- 1 and 39.9 +/- 3.8) and overripe (283.3 +/- 26.2 and 53.5 +/- 4.9). Antioxidant capacity (muMTE/100 g FW) in total polyphenol extracts of ripe durian measured by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and [2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)] (ABTS) assays (259.4 +/- 23.6 and 2341.8 +/- 93.2) were significantly higher (p < 0.05) than that of mature (151.6 +/- 15.2 and 1394.6 +/- 41.5) and overripe (201.7 +/- 19.4 and 1812.2 +/- 61.4) samples. The correlation coefficients between the bioactive compounds in different stages of ripening and their antioxidant capacities were high (R;{2} = 0.99). Then 35 male Wistar rats were divided into 5 dietary groups each of 7 and named Control, Chol, Chol/Mature, Chol/Ripe and Chol/Overripe. During 30 days of the experiment the rats of all 5 groups were fed basal diet (BD), which included wheat starch, casein, soybean oil, vitamin and mineral mixtures. The rats of the Control group were fed a BD only. To the BD of the Chol group was added 1% of cholesterol. The BD of the Chol/Mature, Chol/Ripe and Chol/Overripe groups was supplemented with 1% of cholesterol and 5% of the mature, ripe and overripe durian as freeze-dried powder, respectively. Diets containing ripe and to a lesser degree mature and overripe durian significantly hindered the rise in plasma lipids and also hindered a decrease in plasma antioxidant activity. The nitrogen retention in rats of the Chol/Ripe group was significantly higher (63.6%, P < 0.05) than in other diet groups and the level of the plasma glucose remained normal. A decrease in fibrinogen fraction with ripe durian included in rat's diets was shown by electrophoretic separation. These changes were detected mostly in the low molecular weight proteins of rat's serum. Histological examination of aorta showed only slight differences in the tissue. In conclusion, ripe durian contains higher quantity of bioactive compounds, has higher antioxidant capacity and nutritional value. It positively affects the plasma lipid profile, the plasma glucose and the antioxidant activity in rats fed cholesterol enriched diets. Therefore, the ripe durian supplemented diet could be beneficial for patient suffering from hypercholesterolemia and diabetes mellitus. <

Authors+Show Affiliations

Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Warsaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17673829

Citation

Leontowicz, Maria, et al. "The Nutritional and Metabolic Indices in Rats Fed Cholesterol-containing Diets Supplemented With Durian at Different Stages of Ripening." BioFactors (Oxford, England), vol. 29, no. 2-3, 2007, pp. 123-36.
Leontowicz M, Leontowicz H, Jastrzebski Z, et al. The nutritional and metabolic indices in rats fed cholesterol-containing diets supplemented with durian at different stages of ripening. Biofactors. 2007;29(2-3):123-36.
Leontowicz, M., Leontowicz, H., Jastrzebski, Z., Jesion, I., Haruenkit, R., Poovarodom, S., Katrich, E., Tashma, Z., Drzewiecki, J., Trakhtenberg, S., & Gorinstein, S. (2007). The nutritional and metabolic indices in rats fed cholesterol-containing diets supplemented with durian at different stages of ripening. BioFactors (Oxford, England), 29(2-3), 123-36.
Leontowicz M, et al. The Nutritional and Metabolic Indices in Rats Fed Cholesterol-containing Diets Supplemented With Durian at Different Stages of Ripening. Biofactors. 2007;29(2-3):123-36. PubMed PMID: 17673829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The nutritional and metabolic indices in rats fed cholesterol-containing diets supplemented with durian at different stages of ripening. AU - Leontowicz,Maria, AU - Leontowicz,Hanna, AU - Jastrzebski,Zenon, AU - Jesion,Iwona, AU - Haruenkit,Ratiporn, AU - Poovarodom,Sumitra, AU - Katrich,Elena, AU - Tashma,Zev, AU - Drzewiecki,Jerzy, AU - Trakhtenberg,Simon, AU - Gorinstein,Shela, PY - 2007/8/4/pubmed PY - 2007/12/6/medline PY - 2007/8/4/entrez SP - 123 EP - 36 JF - BioFactors (Oxford, England) JO - Biofactors VL - 29 IS - 2-3 N2 - The aim of this investigation was to assess the nutritional and health properties of Mon Thong durian cultivar at different stages of ripening. The assessment was carried out in vitro and in vivo. The contents of dietary fibers, minerals and trace metals at different stages of ripening were comparable. Total polyphenols (mgGAE/100 g FW) and flavonoids (mg CE/100 gFW) in ripe durian (358.8 +/- 31.4 and 95.4 +/- 9.3) were significantly higher (p < 0.05) than in mature (216.1 +/- 1 and 39.9 +/- 3.8) and overripe (283.3 +/- 26.2 and 53.5 +/- 4.9). Antioxidant capacity (muMTE/100 g FW) in total polyphenol extracts of ripe durian measured by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and [2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)] (ABTS) assays (259.4 +/- 23.6 and 2341.8 +/- 93.2) were significantly higher (p < 0.05) than that of mature (151.6 +/- 15.2 and 1394.6 +/- 41.5) and overripe (201.7 +/- 19.4 and 1812.2 +/- 61.4) samples. The correlation coefficients between the bioactive compounds in different stages of ripening and their antioxidant capacities were high (R;{2} = 0.99). Then 35 male Wistar rats were divided into 5 dietary groups each of 7 and named Control, Chol, Chol/Mature, Chol/Ripe and Chol/Overripe. During 30 days of the experiment the rats of all 5 groups were fed basal diet (BD), which included wheat starch, casein, soybean oil, vitamin and mineral mixtures. The rats of the Control group were fed a BD only. To the BD of the Chol group was added 1% of cholesterol. The BD of the Chol/Mature, Chol/Ripe and Chol/Overripe groups was supplemented with 1% of cholesterol and 5% of the mature, ripe and overripe durian as freeze-dried powder, respectively. Diets containing ripe and to a lesser degree mature and overripe durian significantly hindered the rise in plasma lipids and also hindered a decrease in plasma antioxidant activity. The nitrogen retention in rats of the Chol/Ripe group was significantly higher (63.6%, P < 0.05) than in other diet groups and the level of the plasma glucose remained normal. A decrease in fibrinogen fraction with ripe durian included in rat's diets was shown by electrophoretic separation. These changes were detected mostly in the low molecular weight proteins of rat's serum. Histological examination of aorta showed only slight differences in the tissue. In conclusion, ripe durian contains higher quantity of bioactive compounds, has higher antioxidant capacity and nutritional value. It positively affects the plasma lipid profile, the plasma glucose and the antioxidant activity in rats fed cholesterol enriched diets. Therefore, the ripe durian supplemented diet could be beneficial for patient suffering from hypercholesterolemia and diabetes mellitus. < SN - 0951-6433 UR - https://www.unboundmedicine.com/medline/citation/17673829/The_nutritional_and_metabolic_indices_in_rats_fed_cholesterol_containing_diets_supplemented_with_durian_at_different_stages_of_ripening_ L2 - https://content.iospress.com/openurl?genre=article&amp;issn=0951-6433&amp;volume=29&amp;issue=2-3&amp;spage=123 DB - PRIME DP - Unbound Medicine ER -