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Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations.
Br J Nutr 2008; 99(2):360-9BJ

Abstract

Fish oil supplementation during pregnancy not only improves maternal and neonatal DHA status, but often reduces gamma-linolenic acid (GLA), dihomo-GLA (DGLA), and arachidonic acid (ARA) levels also, which may compromise foetal and infant development. The present study investigated the effects of a fish oil/evening primrose oil (FSO/EPO) blend (456 mg DHA/d and 353 mg GLA/d) compared to a placebo (mixture of habitual dietary fatty acids) on the plasma fatty acid (FA) composition in two groups of twenty non-pregnant women using a randomised, double-blind, placebo-controlled parallel design. FA were quantified in plasma total lipids, phospholipids, cholesterol esters, and TAG at weeks 0, 4, 6 and 8. After 8 weeks of intervention, percentage changes from baseline values of plasma total lipid FA were significantly different between FSO/EPO and placebo for GLA (+49.9 % v. +2.1 %, means), DGLA (+13.8 % v. +0.7 %) and DHA (+59.6 % v. +5.5 %), while there was no significant difference for ARA (- 2.2 % v. - 5.9 %). FA changes were largely comparable between plasma lipid fractions. In both groups three subjects reported mild adverse effects. As compared with placebo, FSO/EPO supplementation did not result in any physiologically relevant changes of safety parameters (blood cell count, liver enzymes). In women of childbearing age the tested FSO/EPO blend was well tolerated and appears safe. It increases plasma GLA, DGLA, and DHA levels without impairing ARA status. These data provide a basis for testing this FSO/EPO blend in pregnant women for its effects on maternal and neonatal FA status and infant development.

Authors+Show Affiliations

Division of Metabolic Diseases and Nutrition, Dr von Hauner Children's Hospital, Ludwig Maximilians University of Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17678567

Citation

Geppert, Julia, et al. "Co-supplementation of Healthy Women With Fish Oil and Evening Primrose Oil Increases Plasma Docosahexaenoic Acid, Gamma-linolenic Acid and Dihomo-gamma-linolenic Acid Levels Without Reducing Arachidonic Acid Concentrations." The British Journal of Nutrition, vol. 99, no. 2, 2008, pp. 360-9.
Geppert J, Demmelmair H, Hornstra G, et al. Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. Br J Nutr. 2008;99(2):360-9.
Geppert, J., Demmelmair, H., Hornstra, G., & Koletzko, B. (2008). Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. The British Journal of Nutrition, 99(2), pp. 360-9.
Geppert J, et al. Co-supplementation of Healthy Women With Fish Oil and Evening Primrose Oil Increases Plasma Docosahexaenoic Acid, Gamma-linolenic Acid and Dihomo-gamma-linolenic Acid Levels Without Reducing Arachidonic Acid Concentrations. Br J Nutr. 2008;99(2):360-9. PubMed PMID: 17678567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. AU - Geppert,Julia, AU - Demmelmair,Hans, AU - Hornstra,Gerard, AU - Koletzko,Berthold, Y1 - 2007/08/03/ PY - 2007/8/7/pubmed PY - 2008/3/12/medline PY - 2007/8/7/entrez SP - 360 EP - 9 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 99 IS - 2 N2 - Fish oil supplementation during pregnancy not only improves maternal and neonatal DHA status, but often reduces gamma-linolenic acid (GLA), dihomo-GLA (DGLA), and arachidonic acid (ARA) levels also, which may compromise foetal and infant development. The present study investigated the effects of a fish oil/evening primrose oil (FSO/EPO) blend (456 mg DHA/d and 353 mg GLA/d) compared to a placebo (mixture of habitual dietary fatty acids) on the plasma fatty acid (FA) composition in two groups of twenty non-pregnant women using a randomised, double-blind, placebo-controlled parallel design. FA were quantified in plasma total lipids, phospholipids, cholesterol esters, and TAG at weeks 0, 4, 6 and 8. After 8 weeks of intervention, percentage changes from baseline values of plasma total lipid FA were significantly different between FSO/EPO and placebo for GLA (+49.9 % v. +2.1 %, means), DGLA (+13.8 % v. +0.7 %) and DHA (+59.6 % v. +5.5 %), while there was no significant difference for ARA (- 2.2 % v. - 5.9 %). FA changes were largely comparable between plasma lipid fractions. In both groups three subjects reported mild adverse effects. As compared with placebo, FSO/EPO supplementation did not result in any physiologically relevant changes of safety parameters (blood cell count, liver enzymes). In women of childbearing age the tested FSO/EPO blend was well tolerated and appears safe. It increases plasma GLA, DGLA, and DHA levels without impairing ARA status. These data provide a basis for testing this FSO/EPO blend in pregnant women for its effects on maternal and neonatal FA status and infant development. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17678567/Co_supplementation_of_healthy_women_with_fish_oil_and_evening_primrose_oil_increases_plasma_docosahexaenoic_acid_gamma_linolenic_acid_and_dihomo_gamma_linolenic_acid_levels_without_reducing_arachidonic_acid_concentrations_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507801577/type/journal_article DB - PRIME DP - Unbound Medicine ER -